Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chelsi J, Snow"'
Autor:
Chelsi J Snow, Michelle Goody, Meghan W Kelly, Emma C Oster, Robert Jones, Andre Khalil, Clarissa A Henry
Publikováno v:
PLoS Genetics, Vol 4, Iss 10, p e1000219 (2008)
Skeletal muscle morphogenesis transforms short muscle precursor cells into long, multinucleate myotubes that anchor to tendons via the myotendinous junction (MTJ). In vertebrates, a great deal is known about muscle specification as well as how somiti
Externí odkaz:
https://doaj.org/article/26ab5f2bedc541978962c9314de2da41
Autor:
Chun-Song Yang, Tiffany A. Melhuish, David Wotton, Thurl E. Harris, Li Ni, Chelsi J. Snow, Kasey Jividen, Adam Spencer, Yi Hao, Bryce M. Paschal, Henry F. Frierson
Publikováno v:
The Prostate. 77:1452-1467
Background Phosphoinositide-3 (PI-3) kinase signaling has a pervasive role in cancer. One of the key effectors of PI-3 kinase signaling is AKT, a kinase that promotes growth and survival in a variety of cancers. Genetically engineered mouse models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5404b20f5cde73b0f4bb7fb88bcb47e3
https://doi.org/10.1002/pros.23400
https://doi.org/10.1002/pros.23400
Autor:
Marwan Shinawi, James W. Wheless, Adam Spencer, Jeanne N. Hansen, Chun Song Yang, Laura A. Jansen, Dalia Ghoneim, Alex R. Paciorkowski, Emily Tuttle, Chelsi J. Snow, William B. Dobyns, Christopher D. Smyser, Christina A. Gurnett, Sonya A. Gunter, Bryce M. Paschal, Marc W. Halterman
Publikováno v:
The American Journal of Human Genetics. 96(4):682-690
Developmental epilepsies are age-dependent seizure disorders for which genetic causes have been increasingly identified. Here we report six unrelated individuals with mutations in salt-inducible kinase 1 (SIK1) in a series of 101 persons with early m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b64caebaa97ca306b007dba0593a70
Autor:
Joshua B. Kelley, Dawid Makosa, Chelsi J. Snow, Natalia Dworak, Mandovi Chatterjee, Chun-Song Yang, Kasey Jividen, William C. Simke, Isaac G Johnson, Bryce M. Paschal
Publikováno v:
Aging Cell
The Ran GTPase regulates nuclear import and export by controlling the assembly state of transport complexes. This involves the direct action of RanGTP, which is generated in the nucleus by the chromatin‐associated nucleotide exchange factor, RCC1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5ba5b8ead2e1665bcbe8d0f40c252d
https://pubmed.ncbi.nlm.nih.gov/30565836
https://pubmed.ncbi.nlm.nih.gov/30565836
Publikováno v:
Molecular Biology of the Cell
In progeria, a mutant form of lamin A constitutively tethered to the inner nuclear membrane causes disruption of the Ran GTPase system by inducing ROS. However, ROS are also induced by disruption of the Ran system. The data suggest that the nuclear l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96eb1b75a18945b179deb4595747c36
http://europepmc.org/articles/PMC3982987
http://europepmc.org/articles/PMC3982987
Publikováno v:
The Journal of Cell Biology
Nuclear transport of large protein cargoes such as Tpr is more sensitive to the alteration of the ratio of nuclear to cytoplasmic Ran that occurs in Progeria.
The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling
The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cffbae2bfb788c783c1599e4e954b0
https://doi.org/10.1083/jcb.201212117
https://doi.org/10.1083/jcb.201212117
Autor:
Chun Song Yang, Mandovi Chatterjee, Adam Spencer, Caelin Cubeñas-Potts, Li Ni, Chelsi J. Snow, Joshua B. Kelley, Sutirtha Datta, Michael J. Matunis, Bryce M. Paschal
Publikováno v:
Molecular and Cellular Biology. 31:3378-3395
The mutant form of lamin A responsible for the premature aging disease Hutchinson-Gilford progeria syndrome (termed progerin) acts as a dominant negative protein that changes the structure of the nuclear lamina. How the perturbation of the nuclear la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81751a6259df9e36944e459c1ccbf9fb
https://doi.org/10.1128/mcb.05087-11
https://doi.org/10.1128/mcb.05087-11
Publikováno v:
Developmental Dynamics. 237:2542-2553
After somitogenesis, skeletal muscle precursors elongate into muscle fibers that anchor to the somite boundary, which becomes the myotome boundary. Fibronectin (Fn) is a major component of the extracellular matrix in both boundaries. Although Fn is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187bb6a87cddcf0c592ff265fc012e1d
https://doi.org/10.1002/dvdy.21670
https://doi.org/10.1002/dvdy.21670
Autor:
Chelsi J Snow, Brian R. Wamhoff, Todd W. Bauer, Robert A. Figler, Michael B. Simmers, Stephen A. Hoang, J. Thomase Parsons, Daniel Gioeli
Publikováno v:
Cancer Research. 77:4935-4935
The development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinical in vitro and mouse studies into clinical benefit. Over 90% of drugs that progress through pre-clinical studies fail in human trials. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cba2c9e2cc93d72728315ae8ac35b4
https://doi.org/10.1158/1538-7445.am2017-4935
https://doi.org/10.1158/1538-7445.am2017-4935
Autor:
Chelsi J, Snow, Bryce M, Paschal
Publikováno v:
Advances in experimental medicine and biology. 773
Tpr is a prominent architectural component of the nuclear pore complex that forms the basket-like structure on the nucleoplasmic side of the pore. Tpr, which stands for translocated promoter region, was originally described in the context of oncogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1cbc3559658e04a31248c6c7ae4d07e
https://pubmed.ncbi.nlm.nih.gov/24563354
https://pubmed.ncbi.nlm.nih.gov/24563354