Výsledky vyhledávání - "Chelsi Flippo"

Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant

Autor: Chelsi Flippo, Vipula Kolli, Melissa Andrew, Seth Berger, Tricia Bhatti, Alison M Boyce, Daniel Casella, Michael T Collins, Emmanuèle Délot, Joseph Devaney, Stephen M Hewitt, Thomas Kolon, Ashwini Mallappa, Perrin C White, Deborah P Merke, Andrew Dauber

Publikováno v: J Endocr Soc

Context Autosomal dominant and rarely de novo gain-of-function variants in the LHCGR gene are associated with precocious male puberty, while somatic LHCGR variants have been found in isolated Leydig cell adenomas and Leydig cell hyperplasia. Bilatera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22264b1da6a571e4780ba5b7a88822c
https://europepmc.org/articles/PMC9469925/

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Subclinical Hemorrhage of ACTH-secreting Pituitary Adenomas in Children and Adolescents Changes Their Biochemical Profile

Autor: Christina Tatsi, Lola Saidkhodjaeva, Chelsi Flippo, Constantine A Stratakis

Publikováno v: J Endocr Soc

Context Subclinical pituitary hemorrhage, necrosis, and/or cystic degeneration (SPH) presents mainly in large tumors and prolactinomas. The characteristics of patients with Cushing disease (CD) and SPH are not known. Objective To determine if SPH aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19e490a80dea26faf0845f3c5dd85a8
https://doi.org/10.1210/jendso/bvac080

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Inflammatory biomarkers in the evaluation of pediatric endogenous Cushing syndrome

Autor: Rachel Wurth, Megan Rescigno, Chelsi Flippo, Constantine A Stratakis, Christina Tatsi

Publikováno v: Eur J Endocrinol

Objective Inflammatory biomarkers, such as absolute neutrophil and lymphocyte counts, neutrophil-to-lymphocyte ratio (NLR), platelet (PLT)-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR), are associated with the progression and devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b05d93c4e7310c3807c5e838ee9c08
https://europepmc.org/articles/PMC9059943/

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Recovery of hypothalamic‐pituitary‐adrenal axis in paediatric Cushing disease

Autor: Megan L. Neely, Maria‐Eleni Bompou, Christina Tatsi, Meg Keil, Constantine A. Stratakis, Chelsi Flippo

Publikováno v: Clinical Endocrinology. 94:40-47

Objectives The postoperative period of Cushing disease (CD) is complicated by a phase of adrenal insufficiency (AI). Factors that influence the duration of AI and its prognostic significance for CD recurrence in children have not been extensively stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f1b089496d0b50eb11bf165ef160a4
https://doi.org/10.1111/cen.14300

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ODP618 The profile of patients with ACTH-secreting pituitary adenomas and subclinical pituitary apoplexy

Autor: Christina Tatsi, Lola Saidkhodjaeva, Chelsi Flippo, Constantine Stratakis

Publikováno v: Journal of the Endocrine Society. 6:A520-A520

Background Subclinical hemorrhage or necrosis of pituitary adenomas (PAs), often defined as subclinical pituitary apoplexy (SPA), presents in up to 20% of all PAs and is more common in large prolactinomas. SPA in corticotropinomas in patients with Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f21fc6dba70e082771c5cadab51d41b0
https://doi.org/10.1210/jendso/bvac150.1083

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Copeptin Levels Before and After Transsphenoidal Surgery for Cushing Disease: A Potential Early Marker of Remission

Autor: Chelsi Flippo, Christina Tatsi, Ninet Sinaii, Maria De La Luz Sierra, Elena Belyavskaya, Charalampos Lyssikatos, Meg Keil, Elias Spanakis, Constantine A Stratakis

Publikováno v: J Endocr Soc

Context Arginine-vasopressin and CRH act synergistically to stimulate secretion of ACTH. There is evidence that glucocorticoids act via negative feedback to suppress arginine-vasopressin secretion. Objective Our hypothesis was that a postoperative in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e708dcea15df4bf4c238b2234b043f
https://pubmed.ncbi.nlm.nih.gov/35528828

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Homozygous SHBG Variant (rs6258) Linked to Gonadotropin-Independent Precocious Puberty in a Young Girl

Autor: Angela Delaney, Geoffrey L. Hammond, Fady Hannah-Shmouni, Chelsi Flippo, Marissa Lightbourne, Constantine A. Stratakis, Fabio R. Faucz, Victoria C. Andriessen

Publikováno v: J Endocr Soc

Sex hormone–binding globulin (SHBG) in the blood is a major determinant of bioactivity for key sex steroids such as testosterone and estradiol. Low serum levels of SHBG have been associated with obesity, polycystic ovaries, and metabolic syndrome,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22ca79f1a4b6c3a25f3d45a419b7db2
https://doi.org/10.1210/jendso/bvab125

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Paediatric patients with Cushing disease and negative pituitary MRI have a higher risk of nonremission after transsphenoidal surgery

Autor: Christina Tatsi, Meg Keil, Constantine A. Stratakis, Prashant Chittiboina, Maria E Bompou, Chelsi Flippo

Publikováno v: Clinical endocrinologyREFERENCES. 95(6)

Objective Diagnostic workup of Cushing disease (CD) involves imaging evaluation of the pituitary gland, but in many patients no tumour is visualised. The aim of this study is to describe the association of magnetic resonance imaging (MRI) findings wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b92387875d76122a5d6263d5388432
https://pubmed.ncbi.nlm.nih.gov/34431123

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