Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Chelsea Massaro"'
Publikováno v:
Medical Sciences, Vol 5, Iss 4, p 32 (2017)
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC). This report describes the development of therapi
Externí odkaz:
https://doaj.org/article/e3c3a71d65b64f36b52e185a21ce4b47
Autor:
Aiste Dobrovolskaite, Holly Moots, Mukund P. Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M. Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel
Publikováno v:
Journal of medicinal chemistry. 65(22)
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid de
Autor:
Holly Moots, Sara Cronk, Sharifa Dinara, Jenna Thomas, Houssine Ikhlef, Otto Phanstiel, Chelsea Massaro
Publikováno v:
Journal of Medicinal Chemistry. 63:2814-2832
Targeting polyamine metabolism is a proven anticancer strategy. Cancers often escape the polyamine biosynthesis inhibitors by increased polyamine import. Therefore, there is much interest in identifying polyamine transport inhibitors (PTIs) to be use
Autor:
Gregory B. Dudley, Suresh Eyunni, Ron R. Ramsubhag, Elizabeth Mazzio, Christina M. Dadich, Andrew J. Janeczek, Chelsea Massaro, Tung T. Hoang, Karam F.A. Soliman
Publikováno v:
Organic & Biomolecular Chemistry. 14:7855-7858
3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with tw
Publikováno v:
Medical Sciences; Volume 5; Issue 4; Pages: 32
Medical Sciences
Medical Sciences, Vol 5, Iss 4, p 32 (2017)
Medical Sciences
Medical Sciences, Vol 5, Iss 4, p 32 (2017)
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC). This report describes the development of therapi