Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chelsea M. Byrd"'
Autor:
Shanthakumar R. Tyavanagimatt, Stone Melialani A C L, Kristin A. Wineinger, Eric Stavale, Pietro Scaturro, Dennis E. Hruby, Christine Schneider, Douglas W. Grosenbach, Kara B. Cardwell, Chelsea M. Byrd, Robert Jordan, Jessica M. Page, Kevin F. Jones, Ralf Bartenschlager, Aklile Berhanu, Dongcheng Dai, Chris Harver
Publikováno v:
PubMed Central
Dengue viruses (DENV) infect 50 to 100 million people worldwide per year, of which 500,000 develop severe life-threatening disease. This mosquito-borne illness is endemic in most tropical and subtropical countries and has spread significantly over th
Autor:
Inger K. Damon, Arthur J. Goff, Wendy Johnson, Tove' C. Bolken, John W. Huggins, Chelsea M. Byrd, Eric M. Mucker, Robert Jordan, Kevin L. Karem, Lisa E. Hensley, Nancy A. Twenhafel, Carly Wlazlowski, Dennis E. Hruby, Josh Shamblin, Tom Larsen, Jennifer Chapman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2620-2625
ST-246, a potent orthopoxvirus egress inhibitor, is safe and effective at preventing disease and death in studies of small-animal models involving challenge by several different pathogenic poxviruses. In this report, the antiviral efficacy of ST-246
Autor:
Eugene Raush, Vladimir Tseitin, Ruben Abagyan, Vsevolod Katritch, Chelsea M. Byrd, Maxim Totrov, Robert Jordan, Dennis E. Hruby, Dongcheng Dai
Publikováno v:
Journal of Computer-Aided Molecular Design
Essential for viral replication and highly conserved among poxviridae, the vaccinia virus I7L ubiquitin-like proteinase (ULP) is an attractive target for development of smallpox antiviral drugs. At the same time, the I7L proteinase exemplifies severa
Autor:
Chelsea M. Byrd, Dennis E. Hruby
Publikováno v:
Drug Development Research
During antiviral drug development, any essential stage of the viral life cycle can serve as a potential drug target. Since most viruses encode specific proteases whose cleavage activity is required for viral replication, and whose structure and activ
Autor:
Dennis E. Hruby, Chelsea M. Byrd
Publikováno v:
Microbe Magazine. 1:70-75
Before progeny virus particles depart an infected cell, each virion needs to contain viral nucleic acid, accessory proteins, and enzymes within an outer shell before the capsid structure is completed to shield the sensitive cargo from the external en
Autor:
Chelsea M. Byrd, Dennis E. Hruby
Publikováno v:
Reviews in Medical Virology
It is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure th
Autor:
Mohan Rao, Robert C. Andrews, Robert Rothlein, Tove' C. Bolken, Murty N. Arimilli, Adnan M. M. Mjalli, Tariq Andrea, Katrina L. Owens, Dennis E. Hruby, Chelsea M. Byrd
Publikováno v:
Journal of Virology. 78:12147-12156
By using a homology-based bioinformatics approach, a structural model of the vaccinia virus (VV) I7L proteinase was developed. A unique chemical library of ∼51,000 compounds was computationally queried to identify potential active site inhibitors.
Publikováno v:
Journal of Virology. 76:8973-8976
Maturation of vaccinia virus (VV) core proteins is required for the production of infectious virions. The VV G1L and I7L gene products are the leading candidates for the viral core protein proteinase (vCPP). Using transient-expression assays, data we
Autor:
Zach Blackwood, Anthony T. Vella, Kevin F. Jones, Travis K. Warren, Jenny McDonald, David S. King, Chelsea M. Byrd, Tove' C. Bolken, Dennis E. Hruby
Publikováno v:
Vaccine. 20:2197-2205
To test the effect of co-expression of immunomodulatory molecules, together with target antigen, two recombinant Streptococcus gordonii strains were constructed which secreted either murine interleukin-2 (IL-2) or interferon-gamma (IFN-gamma) in addi
Publikováno v:
Current opinion in virology. 3(5)
A key to biodefense strategies is an assessment of current therapies available as well as the expedited development of new antiviral therapeutic options. Viruses make up the majority of the National Institute of Allergy and Infectious Diseases (NIAID