Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Chelsea L Faber"'
Autor:
Chelsea L Faber, Jennifer D Deem, Bao Anh Phan, Tammy P Doan, Kayoko Ogimoto, Zaman Mirzadeh, Michael W Schwartz, Gregory J Morton
Publikováno v:
eLife, Vol 10 (2021)
The brain plays an essential role in driving daily rhythms of behavior and metabolism in harmony with environmental light–dark cycles. Within the brain, the dorsomedial hypothalamic nucleus (DMH) has been implicated in the integrative circadian con
Externí odkaz:
https://doaj.org/article/de654672db84412caa24254afde95e76
Autor:
Jennifer D Deem, Chelsea L Faber, Christian Pedersen, Bao Anh Phan, Sarah A Larsen, Kayoko Ogimoto, Jarrell T Nelson, Vincent Damian, Megan A Tran, Richard D Palmiter, Karl J Kaiyala, Jarrad M Scarlett, Michael R Bruchas, Michael W Schwartz, Gregory J Morton
Publikováno v:
eLife, Vol 9 (2020)
To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked wh
Externí odkaz:
https://doaj.org/article/3bf1e03edc9c473196f7e1c90cbf2a36
Autor:
Marie A. Bentsen, Dylan M. Rausch, Zaman Mirzadeh, Kenjiro Muta, Jarrad M. Scarlett, Jenny M. Brown, Vicente Herranz-Pérez, Arian F. Baquero, Jonatan Thompson, Kimberly M. Alonge, Chelsea L. Faber, Karl J. Kaiyala, Camdin Bennett, Charles Pyke, Cecilia Ratner, Kristoffer L. Egerod, Birgitte Holst, Thomas H. Meek, Burak Kutlu, Yu Zhang, Thomas Sparso, Kevin L. Grove, Gregory J. Morton, Birgitte R. Kornum, José-Manuel García-Verdugo, Anna Secher, Rasmus Jorgensen, Michael W. Schwartz, Tune H. Pers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
In rodent models of type 2 diabetes, sustained remission of hyperglycemia can be induced by FGF1 action in the mediobasal hypothalamus. Here, the authors show that FGF1-injection is followed by marked changes in glial cell populations and that the su
Externí odkaz:
https://doaj.org/article/3be801c6633040a49c4814f636359746
Publikováno v:
Diabetes Care
“Relative hypoglycemia” is an often-overlooked complication of diabetes characterized by an increase in the glycemic threshold for detecting and responding to hypoglycemia. The clinical relevance of this problem is linked to growing evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f66b11df088a3f924094fe5beb5ec1
https://doi.org/10.2337/dc22-1445
https://doi.org/10.2337/dc22-1445
Autor:
Alan C. Rupp, Margaret B. Allison, Justin C. Jones, Christa M. Patterson, Chelsea L. Faber, Nadejda Bozadjieva, Lora K. Heisler, Randy J. Seeley, David P. Olson, Martin G. Myers, Jr.
Publikováno v:
Molecular Metabolism, Vol 14, Iss , Pp 130-138 (2018)
Objective: To date, early developmental ablation of leptin receptor (LepRb) expression from circumscribed populations of hypothalamic neurons (e.g., arcuate nucleus (ARC) Pomc- or Agrp-expressing cells) has only minimally affected energy balance. In
Externí odkaz:
https://doaj.org/article/c98d701724a746e98f6e1b6ad33a19ac
Publikováno v:
FEBS J
Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti-related peptide (AgRP) govern a critical aspect of survival: the drive to eat. Equally important to survival is the timing at which food is consumed - seeking or eating food to all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508c0e1c419b7c94dc14a9a70159b6c6
https://doi.org/10.1111/febs.16176
https://doi.org/10.1111/febs.16176
Autor:
Kimberly M. Alonge, Randy Woltjer, Bao Anh Phan, William A. Banks, C. Dirk Keene, Vy Nguyen, Chelsea L. Faber, Michael W. Schwartz, Caitlin S. Latimer, Naly Setthavongsack, Kendra L. Francis, Aric F. Logsdon, Nicole E. Richardson, Jarrad M. Scarlett, Shannon J. Hu
Publikováno v:
Alzheimers Dement
The extracellular matrix (ECM) of the brain is comprised of unique glycan “sulfation codes” that influence neurological function. Perineuronal nets (PNNs) are chondroitin sulfate-glycosaminoglycan (CS-GAG) containing matrices that enmesh neural n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2781e87abfc130ef6d27b26951322861
https://doi.org/10.1002/alz.12451
https://doi.org/10.1002/alz.12451
Autor:
JENNIFER D. DEEM, DAVID TINGLEY, ANNE-METTE BJERREGAARD, CHELSEA L. FABER, TAMMY P. DOAN, BAO ANH N. PHAN, ZAINAB NASIR, BRANDON WU, MATTHEW K. HWANG, ASMIT KUMAR, JARRAD M. SCARLETT, GREGORY J. MORTON, MICHAEL W. SCHWARTZ
Publikováno v:
Diabetes. 71
The brain’s capacity to normalize the defended blood glucose level in diabetic animals is now well established. We hypothesized that for this to occur, the brain, like the pancreas, must detect and respond to changes in circulating glucose, but whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b87aa16aa86d150669de11da8362a2
https://doi.org/10.2337/db22-209-lb
https://doi.org/10.2337/db22-209-lb
Autor:
Chelsea L. Faber, Tammy M. Barnes, Martin G. Myers, Wenwen Cheng, Margaret B. Allison, Gabrielle K. Steinl, Justin C. Jones, Kimi Shah, Desiree Gordian, Abigail J Tomlinson, Paul V. Sabatini, Qing Zhu
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 32, Iss, Pp 168-175 (2020)
Molecular Metabolism, Vol 32, Iss, Pp 168-175 (2020)
Background Leptin acts via its receptor, LepRb, on specialized neurons in the brain to modulate energy balance and glucose homeostasis. LepRb→STAT3 signaling plays a crucial role in leptin action, but LepRb also mediates an additional as-yet-uniden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6530853594b0b30fe7c1b9c7b747b3ca
http://europepmc.org/articles/PMC6992902
http://europepmc.org/articles/PMC6992902
Publikováno v:
Annu Rev Pharmacol Toxicol
Historically, pancreatic islet beta cells have been viewed as principal regulators of glycemia, with type 2 diabetes (T2D) resulting when insulin secretion fails to compensate for peripheral tissue insulin resistance. However, glycemia is also regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947f111d82125d9c6152379d03ea8b41
https://europepmc.org/articles/PMC8900291/
https://europepmc.org/articles/PMC8900291/
