Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.

Autor: Chelsea Fischer, Iosune Ibiricu Urriza, Christina A Bulman, K C Lim, Jiri Gut, Sophie Lachau-Durand, Marc Engelen, Ludo Quirynen, Fetene Tekle, Benny Baeten, Brenda Beerntsen, Sara Lustigman, Judy Sakanari

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006787 (2019)

River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are re

Externí odkaz: https://doaj.org/article/242d359b1ba14723bac1cecbb901a1d9

An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease

Autor: Rahul Tyagi, Christina A. Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R. Arkin, James H. McKerrow, Case W. McNamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W. Janetka, Sara Lustigman, Judy Sakanari, Makedonka Mitreva

Publikováno v: Pathogens, Vol 10, Iss 1, p 71 (2021)

Filarial worms cause multiple debilitating diseases in millions of people worldwide, including river blindness. Currently available drugs reduce transmission by killing larvae (microfilariae), but there are no effective cures targeting the adult para

Externí odkaz: https://doaj.org/article/4b9a387fd8184bb3b46400e12541ea35

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

Autor: Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock

Publikováno v: ACS Infectious Diseases

The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beee7fb4c5ebfd7c32f697f2a5ce9791
https://doi.org/10.1021/acsinfecdis.9b00397

Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections

Autor: David L. Williams, Peter Ziniel, Christina A. Bulman, Alexandre Taravaud, Fidelis Cho-Ngwa, Liwen Feng, Chelsea Fischer, Sébastien Pomel, Perle Latré de Laté, Philippe M. Loiseau, Louis Maes, Judy A. Sakanari, Elisabeth Davioud-Charvet

Publikováno v: Molecules, Vol 25, Iss 5075, p 5075 (2020)
Molecules
Molecules, MDPI, 2020, 25 (21), pp.5075. ⟨10.3390/molecules25215075⟩
Molecules: a journal of synthetic chemistry and natural product chemistry
Volume 25
Issue 21

Neglected parasitic diseases remain a major public health issue worldwide, especially in tropical and subtropical areas. Human parasite diversity is very large, ranging from protozoa to worms. In most cases, more effective and new drugs are urgently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350b25519806f515ff59b05252e4d068
https://www.mdpi.com/1420-3049/25/21/5075

Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

Autor: James W. Janetka, Amarendar Reddy Maddirala, Paul J. Brindley, Judy A. Sakanari, Jonathan D.M. Helander, Iain R. Greig, Scott A. Wildman, Rahul Tyagi, Chih-Chung Tseng, Christina A. Bulman, Mostafa A. Elfawal, Bruce A. Rosa, Makedonka Mitreva, Chelsea Fischer, Xin Gao, Raffi V. Aroian, Mingzhou Zhou, Ryan Chugani

Publikováno v: ACS Infectious Diseases. 4:1130-1145

The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery of new drugs. Herein, we have identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37c680e6e7e0044ad4a5f1e06cec768
https://doi.org/10.1021/acsinfecdis.8b00090