Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chelsea Dumesny"'
Autor:
Yi Ma, Chelsea Dumesny, Li Dong, Ching-Seng Ang, Khashayar Asadi, Yifan Zhan, Mehrdad Nikfarjam, Hong He
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal types of cancer, and KRAS oncogene occurs in over 90% of cases. P21-activated kinases (PAK), containing six members (PAK1 to 6), function downstream of KRAS. PAK1 an
Externí odkaz:
https://doaj.org/article/9e0cfb4ddaad4b95964ffbedda73cc71
Publikováno v:
Translational Oncology, Vol 16, Iss , Pp 101329- (2022)
Over 95% of Pancreatic ductal adenocarcinomas (PDA) carry mutations in the oncogene KRas which has been proven to be a difficult drug target. P21-activated kinase 4 (PAK4), acts downstream of KRas, and is overexpressed in PDA contributing to its grow
Externí odkaz:
https://doaj.org/article/15508468749e41bbadc73419c2427e86
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8035, p 8035 (2020)
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8035, p 8035 (2020)
The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((&minus
)-trans-∆9-tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The connection of these cannabinoids to KRas oncogenes that mutate
)-trans-∆9-tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The connection of these cannabinoids to KRas oncogenes that mutate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6e4f619631771f07e9753d2d4386ce
http://europepmc.org/articles/PMC7662796
http://europepmc.org/articles/PMC7662796
Publikováno v:
Metallomics. 10:194-200
Immature forms of the peptide hormone gastrin have been implicated in the development of colorectal cancer (CRC). The biological activity of glycine-extended gastrin (Ggly) is dependent on the binding of Fe3+ ions in vitro and in vivo. The aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac326daf8905612094958fb6d00ee9f2
https://doi.org/10.1039/c7mt00272f
https://doi.org/10.1039/c7mt00272f
Autor:
Yifan Zhan, Mehrdad Nikfarjam, Graham S. Baldwin, Chelsea Dumesny, David Herrmann, Hong S. He, Kai Wang, Paul Timpson, Nhi Huynh, Yang Yang, Xiao Wang, Katrina A Walsh, Khashayer Asadi
Publikováno v:
Cancer letters. 472
Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence of an immunosuppressive tumour microenvironment (TME) characterized by a desmoplastic stroma containing infiltrated imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2638585018157fab07f21869cf667a
https://pubmed.ncbi.nlm.nih.gov/31857154
https://pubmed.ncbi.nlm.nih.gov/31857154
Publikováno v:
Metallomics : integrated biometal science. 10(1)
Immature forms of the peptide hormone gastrin have been implicated in the development of colorectal cancer (CRC). The biological activity of glycine-extended gastrin (Ggly) is dependent on the binding of Fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb855e490327754449a84662d7c617af
https://pubmed.ncbi.nlm.nih.gov/29296993
https://pubmed.ncbi.nlm.nih.gov/29296993
Autor:
Mildred Yim, Mehrdad Nikfarjam, Chelsea Dumesny, Nhi Huynh, Graham S. Baldwin, Hong S. He, Mauro S. Sandrin, Kai Wang
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)
Background P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a643a30e2dee72734dfa9ac57f2e344
https://doi.org/10.1186/s12885-017-3432-0
https://doi.org/10.1186/s12885-017-3432-0
Publikováno v:
Cancer Letters. 254:87-93
C-terminal fragments from the precursor for gastrin-releasing peptide (GRP) have been detected in several human tumour types. We have previously demonstrated that recombinant human proGRP42-98 is biologically active. To investigate the regions respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f709f0ff194239e220e3a27d3521a053
https://doi.org/10.1016/j.canlet.2007.02.014
https://doi.org/10.1016/j.canlet.2007.02.014
Autor:
Shamilah Lachal, Andrew S. Giraud, Graham S. Baldwin, Oneel Patel, Chelsea Dumesny, Arthur Shulkes
Publikováno v:
Endocrinology. 147:502-509
Gastrin-releasing peptide (GRP) has a widespread distribution and multiple stimulating effects on endocrine and exocrine secretions and metabolism. The prohormone for GRP (ProGRP, 125 amino acids) is processed to the amidated, biologically active end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8008bd07e6df20bc595fab544e3f8e
https://doi.org/10.1210/en.2005-0574
https://doi.org/10.1210/en.2005-0574
Publikováno v:
Biochemical Pharmacology. 68:2129-2142
Although amidated forms of gastrin-releasing peptide (GRP) have been identified as autocrine growth factors in small cell lung cancer, their role in the development and progression of colorectal carcinoma is less clear. In addition, the biological ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4c502b93a620777d1f61c40f8594cb
https://doi.org/10.1016/j.bcp.2004.08.009
https://doi.org/10.1016/j.bcp.2004.08.009