Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Chelsea Bahney"'
Autor:
Anna Laura Nelson, Chiara Mancino, Xueqin Gao, Joshua A. Choe, Laura Chubb, Katherine Williams, Molly Czachor, Ralph Marcucio, Francesca Taraballi, John P. Cooke, Johnny Huard, Chelsea Bahney, Nicole Ehrhart
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 273-286 (2024)
Fractures continue to be a global economic burden as there are currently no osteoanabolic drugs approved to accelerate fracture healing. In this study, we aimed to develop an osteoanabolic therapy which activates the Wnt/β-catenin pathway, a molecul
Externí odkaz:
https://doaj.org/article/81cdecd9e4f146d3b17d47743564e65b
Autor:
Anna Laura Nelson, Gianluca Fontana, Laura Chubb, Josh Choe, Katherine Williams, Dan Regan, Johnny Huard, William Murphy, Nicole Ehrhart, Chelsea Bahney
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Introduction: Impaired fracture healing, specifically non-union, has been found to occur up to 14% in tibial shaft fractures. The current standard of care to treat non-union often requires additional surgeries which can result in long recovery times.
Externí odkaz:
https://doaj.org/article/a43e033925654debae790606c7222b4f
Autor:
William S. Hambright, Xiaodong Mu, Xueqin Gao, Ping Guo, Yohei Kawakami, John Mitchell, Michael Mullen, Anna-Laura Nelson, Chelsea Bahney, Haruki Nishimura, Justin Hellwinkel, Andrew Eck, Johnny Huard
Publikováno v:
Journal of Osteoporosis, Vol 2023 (2023)
Aging leads to several geriatric conditions including osteoporosis (OP) and associated frailty syndrome. Treatments for these conditions are limited and none target fundamental drivers of pathology, and thus identifying strategies to delay progressiv
Externí odkaz:
https://doaj.org/article/2beef3c3f7ee472b8101fa6693ed2c82
Autor:
Melanie Haffner-Luntzer, Birte Weber, Kazuhito Morioka, Ina Lackner, Verena Fischer, Chelsea Bahney, Anita Ignatius, Miriam Kalbitz, Ralph Marcucio, Theodore Miclau
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionClinical and preclinical data suggest accelerated bone fracture healing in subjects with an additional traumatic brain injury (TBI). Mechanistically, altered metabolism and neuro-endocrine regulations have been shown to influence bone for
Externí odkaz:
https://doaj.org/article/8225009ee1cb423ca02c124f13c93b63
Autor:
Shierly W. Fok, Robert C. H. Gresham, Weston Ryan, Benjamin Osipov, Chelsea Bahney, J. Kent Leach
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Recombinant growth factors are used in tissue engineering to stimulate cell proliferation, migration, and differentiation. Conventional methods of growth factor delivery for therapeutic applications employ large amounts of these bioactive cues. Effec
Externí odkaz:
https://doaj.org/article/090c54021cd946159aa74cd05fb42087
Autor:
Robert A. Waltz, Kaitlyn E. Whitney, Victoria R. Duke, Heidi Kloser, Charles Huard, Matthew T. Provencher, Marc J. Philippon, Chelsea Bahney, Jonathan A. Godin, Johnny Huard
Publikováno v:
Life, Vol 13, Iss 7, p 1567 (2023)
Background: Senescence, a characteristic of cellular aging and inflammation, has been linked to the acceleration of osteoarthritis. The purpose of this study is to prospectively identify, measure, and compare senescent profiles in synovial fluid and
Externí odkaz:
https://doaj.org/article/2b44ae7ba165455c83ef2d05991a1427
Autor:
Anna Laura, Nelson, GianLuca, Fontana, Elizabeth, Miclau, Mallory, Rongstad, William, Murphy, Johnny, Huard, Nicole, Ehrhart, Chelsea, Bahney
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 16:961-976
Activation of the canonical Wingless-related integration site (Wnt) pathway has been shown to increase bone formation and therefore has therapeutic potential for use in orthopedic conditions. However, attempts at developing an effective strategy to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a71c42dda07838077c3daac7a85f83e
https://doi.org/10.1002/term.3349
https://doi.org/10.1002/term.3349
Autor:
Christopher B. Erickson, Ryan Hill, Donna Pascablo, Galateia Kazakia, Kirk Hansen, Chelsea Bahney
Publikováno v:
J Life Sci (Westlake Village)
While most bones fully self-heal, certain diseases require bone allograft to assist with fracture healing. Bone allografts offer promise as treatments for such fractures due to their osteogenic properties. However, current bone allografts made of dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ab961522ae6050d7a8cea9f7695ee5
https://pubmed.ncbi.nlm.nih.gov/35765657
https://pubmed.ncbi.nlm.nih.gov/35765657
Autor:
Kohei, Yamaura, Anna Laura, Nelson, Haruki, Nishimura, Joan C, Rutledge, Sudheer K, Ravuri, Chelsea, Bahney, Marc J, Philippon, Johnny, Huard
Publikováno v:
Pharmacological Research. 185:106504
As the worldwide population progresses in age, there is an increasing need for effective treatments for age-associated musculoskeletal conditions such as osteoporosis and osteoarthritis (OA). Fisetin, a natural flavonoid, has garnered attention as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed254d8f570b7a5d5e37bd1f20544de9
https://doi.org/10.1016/j.phrs.2022.106504
https://doi.org/10.1016/j.phrs.2022.106504
Autor:
Kaitlyn Whitney, Heidi Kloser, Charles Huard, Chelsea Bahney, Matthew Provencher, Jonathan Godin, Johnny Huard, Robert Waltz
Publikováno v:
Orthopaedic Journal of Sports Medicine. 10:2325967121S0077
Objectives: Synovial fluid profiles in the setting of intra-articular ligament injury remains largely undefined and may play a significant role in graft incorporation and the development of fibrosis and PTOA. Senescence, a characteristic of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5de79f271eae71ab8fd56f94b62c9cf
https://doi.org/10.1177/2325967121s00778
https://doi.org/10.1177/2325967121s00778