Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chek Shik Lim"'
Autor:
Chek Shik Lim, Advait Nagle, Chun Li, Clemens H. M. Kocken, Pranab Mishra, Tove Tuntland, Wei Lin Sandra Sim, Rachel Borboa, Case W. McNamara, Seh Yong Leong, Nobutaka Kato, Christophe Bodenreider, Anne-Marie Zeeman, Prasuna Guntapalli, Kelli Kuhen, Thomas Hollenbeck, Thierry T. Diagana, Arnab K. Chatterjee, Elizabeth A. Winzeler, Liying Jocelyn Tan, Jonathan Chang, Siti Nurdiana Abas, Paul W. Smith, Bryan K. S. Yeung, Yong Cheng Tan, David C. Tully, Jason Roland, Suresh B. Lakshminarayana, Bin Zou, Kerstin Gagaring
Publikováno v:
ACS Medicinal Chemistry Letters. 5:947-950
Imidazopyridine 1 was identified from a phenotypic screen against P. falciparum (Pf) blood stages and subsequently optimized for activity on liver-stage schizonts of the rodent parasite P. yoelii (Py) as well as hypnozoites of the simian parasite P.
Autor:
Stephan Meister, Richard Glynne, Uwe Plikat, N. Rao Movva, Chek Shik Lim, Christian Studer, Frantisek Supek, Esther K. Schmitt, David Plouffe, Susan McCormack, Case W. McNamara, Frank Staedtler, Simona Cotesta, Mark C. Fishman, Elizabeth A. Winzeler, Thomas Aust, Sven Schuierer, Jeffrey A. Porter, Nicole Hartmann, Dominic Hoepfner, Frank Petersen, Ralph Riedl, John A. Tallarico, Christophe Bodenreider, Thierry T. Diagana
Publikováno v:
Cell Host & Microbe. 11:654-663
SummaryWith renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver- and blood-stage infections. We screened a natural product library to identify inhibit
Autor:
David Y.-K. Chen, Chek Shik Lim, Sin Yee Ng, Rong Ji Sum, Vengala Rao Ravu, Gulice Y. C. Leung
Publikováno v:
European Journal of Organic Chemistry. 2011:463-468
In this communication, second-generation analogues of palmerolide A, a recently reported cytotoxic agent against melanoma cancer cells, were rationally designed, synthesized, and biologically evaluated. Structural variations of the enamide side chain
Autor:
Leslie J. Street, David Waterson, Robert W. Sauerwein, Jeremy N. Burrows, Claire Le Manach, Sara E. Zakutansky, Karen L. White, Suresh Solapure, Yassir Younis, Anne-Marie Zeeman, Michael J Witty, Santiago Ferrer, Mariette Botha, Marcus Bantscheff, Susan A. Charman, Kennan C. Marsh, Christian Scheurer, Francisco-Javier Gamo, Rosemary Rochford, Rajshekhar Basak, Janette Reader, María Belén Jiménez-Díaz, Sonja Ghidelli-Disse, Chek Shik Lim, Clemens H. M. Kocken, Lyn-Marie Birkholtz, Kelly Chibale, Kirsten K. Hanson, Didier Leroy, Brice Campo, Koen J. Dechering, Andrea Ruecker, David M. Shackleford, Pattaraporn Vanachayangkul, Tara S. Abraham, Sergio Wittlin, Cristina Donini, Christophe Bodenreider, Iñigo Angulo-Barturen, David A. Fidock, Marcus C. S. Lee, Diego Gonzàlez Cabrera, Maria Jose Lafuente-Monasterio, María Santos Martínez, Julia Morizzi, Michael J. Delves, Tanya Paquet, Andrew M. Blagborough, Anchalee Tungtaeng, Laura M. Sanz, Janne Mannila, Gerard Drewes, Philipp P. Henrich
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science Translational Medicine, 9, 387, pp. pii: eaad9735-pii: eaad9735
Science Translational Medicine, 9, pii: eaad9735-pii: eaad9735
Consejería de Sanidad de la Comunidad de Madrid
Science Translational Medicine, 9, 387, pp. pii: eaad9735-pii: eaad9735
Science Translational Medicine, 9, pii: eaad9735-pii: eaad9735
Contains fulltext : 177492.pdf (Publisher’s version ) (Closed access) As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good starting point to develop
Autor:
Chek Shik Lim, Badry Bursulaya, Nobutaka Kato, Anne-Marie Zeeman, Micah J. Manary, Elizabeth A. Winzeler, Robert W. Sauerwein, Christoph Fischli, Kerstin Gagaring, David A. Fidock, François Nosten, Jason Roland, David Plouffe, Case W. McNamara, Thierry T. Diagana, Maureen Ibanez, Martijn Timmerman, Tr Santha Kumar, Oliver Simon, Lucia E. Rameh, Arnab K. Chatterjee, Stephan Meister, Susan McCormack, Rossarin Suwanarusk, Clemens H. M. Kocken, Koen J. Dechering, Kelli Kuhen, Philipp P. Henrich, Joerg Trappe, Siau Hoi Lim, Matthias Rottmann, Richard Glynne, Christophe Bodenreider, Bryan K. S. Yeung, Advait Nagle, Bruce Russell, Marcus C. S. Lee, David C. Tully, Laurent Rénia, Dorothea Haasen
Publikováno v:
Nature
Nature, vol 504, iss 7479
Nature, vol 504, iss 7479
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as the target of imidazopyrazines, a new antimalarial
Publikováno v:
Journal of the American Chemical Society. 132(21)
The total synthesis and biological evaluation of the resveratrol-derived natural products hopeanol (2) and hopeahainol A (3) in their racemic and antipodal forms are described. The Friedel-Crafts-based synthetic strategy employed was developed from m
Autor:
Ya-Ping Sun, Damien Polet, Kyriacos C. Nicolaou, Bin Zou, Xiao-Shui Peng, Chek Shik Lim, David Y.-K. Chen
Publikováno v:
ChemInform. 41
Autor:
Chek Shik Lim, Ya-Ping Sun, Kyriacos C. Nicolaou, Bin Zou, Xiao-Shui Peng, Damien Polet, David Y.-K. Chen
Publikováno v:
Journal of the American Chemical Society. 131(30)
Total syntheses of the highly selective antiproliferative natural products cortistatins A (1) and J (5) in their naturally occurring enantiomeric forms are described. The modular and convergent strategy employed relies on an intramolecular oxa-Michae
Autor:
Chek Shik Lim, Ramakrishna Guduru, Ya-Ping Sun, David Y.-K. Chen, Dattatraya H. Dethe, Kyriacos C. Nicolaou, Gulice Y. C. Leung
Publikováno v:
Journal of the American Chemical Society. 130(30)
Molecular design and chemical synthesis of several palmerolide A analogues allowed the first structure activity relationships (SARs) of this newly discovered marine antitumor agent. From several analogues synthesized and tested (ent- 1, 5- 14, 21- 26
Autor:
Nicolaou, K. C.1 kcn@scripps.edu, Xiao-Shui Peng1, Ya-Ping Sun1, Polet, Damien1, Bin Zou1, Chek Shik Lim1, Chen, David Y.-K.1 davidchen@ices.a-star.edu.sg
Publikováno v:
Journal of the American Chemical Society. 8/5/2009, Vol. 131 Issue 30, p10587-10597. 11p. 1 Diagram, 2 Graphs.