Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry

Autor: Abram Bunya Kamiza, Sounkou M. Touré, Feng Zhou, Opeyemi Soremekun, Cheickna Cissé, Mamadou Wélé, Aboubacrine M. Touré, Oyekanmi Nashiru, Manuel Corpas, Moffat Nyirenda, Amelia Crampin, Jeffrey Shaffer, Seydou Doumbia, Eleftheria Zeggini, Andrew P. Morris, Jennifer L. Asimit, Tinashe Chikowore, Segun Fatumo

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To furt

Externí odkaz: https://doaj.org/article/fda3a3062d654543b37f9904f3bc6787

Discovery and fine-mapping of lipid traits loci in 125,000 individuals of African ancestry

Autor: Abram Kamiza, Sounkou Touré, Fend Zhou, Opeyemi Soremekun, Cheickna Cissé, Mamadou Wele, Aboubacrine Touré, Oyekanmi Nashiru, Manuel Corpas, Moffat Nyirenda, Amelia Crampin, Jeffrey Shaffer, Seydou Doumbia, Eleftheria Zeggini, Andrew Morris, Jennifer Asimit, Tinashe Chikowore, Segun Fatumo

Most of the genome-wide association studies (GWAS) for lipid traits focus on single lipid traits. There are limited GWASs evaluating the variants associated with two or more lipid traits in African ancestry. To further identify and localize genetic l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f204c190abcec2988d028be405e6fef
https://doi.org/10.21203/rs.3.rs-2639461/v1

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From Peptide Aptamers to Inhibitors of FUR, Bacterial Transcriptional Regulator of Iron Homeostasis and Virulence

Autor: Cheickna Cissé, Roger Miras, Serge Crouzy, Isabelle Michaud-Soret, Mélissa Degardin, Julien Pérard, Aynur Ahmadova, Sylvia Vitale, Didier Boturyn, Sophie Mathieu, Pierre Colas, Jacques Covès

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, 2016, 11 (9), pp.2519-2528. ⟨10.1021/acschembio.6b00360⟩
ACS Chemical Biology, American Chemical Society, 2016, 11 (9), pp.2519-2528. ⟨10.1021/acschembio.6b00360⟩

International audience; FUR (Ferric Uptake Regulator) protein is a global transcriptional regulator that senses iron status and controls the expression of genes involved in iron homeostasis, virulence, and oxidative stress. Ubiquitous in Gram-negativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02347aed444734f028c7d40094b332d
https://hal.science/hal-01354302