Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Chehade N. Karam"'
1
ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression
Autor: Lin Zhang, Jianjie Ma, Jianxun Yi, Tian Yu, Huan Wang, Yajuan Xiao, Kamal Dhakal, Dosuk Yoon, Chehade N. Karam, Zhaohui Mo, Paul Ramlow, Xuejun Li, Jingsong Zhou
Publikováno v: Pharmacological Research. 138:25-36
In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the diseasestage-dependent changes of mitochondrial function and their relatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ab11b94652e7cc291866d69a0bd2de
https://doi.org/10.1016/j.phrs.2018.09.008
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2
Peroxisome proliferator-activated receptor-α expression induces alterations in cardiac myofilaments in a pressure-overload model of hypertrophy
Autor: Chehade N. Karam, E. Douglas Lewandowski, R. John Solaro, Marcus Henze, Natasha H. Banke, Chad M. Warren
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 312:H681-H690
Although alterations in fatty acid (FA) metabolism have been shown to have a negative impact on contractility of the hypertrophied heart, the targets of action remain elusive. In this study we compared the function of skinned fiber bundles from trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8218fe2f6efed24106084f16ffecb15
https://doi.org/10.1152/ajpheart.00469.2016
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4
Green Tea Catechin Normalizes the Enhanced Ca 2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy–Associated Mutation in Human Cardiac Troponin I (K206I)
Autor: Pieter P. de Tombe, Michael J. Ackerman, Chad M. Warren, J. Martijn Bos, Beata M. Wolska, Tomoyoshi Kobayashi, Grace M. Arteaga, R. John Solaro, Chehade N. Karam
Publikováno v: Circulation: Cardiovascular Genetics. 8:765-773
Background— Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease characterized by thickening of ventricular walls and decreased left ventricular chamber volume. The majority of HCM-associated mutations are found in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ecddc292b7670da94d6be50d5b3c9c
https://doi.org/10.1161/circgenetics.115.001234
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5
Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation
Autor: Kaitao Li, Chehade N. Karam, Lin Zhang, Jianjie Ma, Kamal Dhakal, Xuejun Li, Jingsong Zhou, Heping Cheng, Carlo Manno, Jiejia Xu, Jianxun Yi, Yajuan Xiao
Publikováno v: Skeletal Muscle, Vol 7, Iss 1, Pp 1-18 (2017)
Background Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21df5876fa99d8ec05760bf05708a36
https://doi.org/10.1186/s13395-017-0123-0
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7
Absence of Physiological Calcium Transients Triggers Mitochondrial ROS Production in Skeletal Muscle Following Denervation
Autor: Jianxun Yi, Jingsong Zhou, Jianjie Ma, Chehade N. Karam, Carlos Manno, Heping Cheng
Publikováno v: Biophysical Journal. 110(3)
Motoneurons control muscle contraction by initiating action potentials in muscle fibers. Denervation of muscle fiber from the motoneuron will lead to muscle paralysis and atrophy, which is often linked to mitochondrial dysfunction. It is known that d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411fe2b943f77dbb548fe53e593048a0
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9
Effect of type-1 diabetes mellitus on the regulation of insulin and endothelin-1 receptors in rat hearts
Autor: Chehade N. Karam, Nuha Nuwayri-Salti, Wael M Maharsy, Julnar Usta, Khalil M. Bitar, Anwar B. Bikhazi, Wael A Jaroudi
Publikováno v: Canadian Journal of Physiology and Pharmacology. 85:215-224
This project assesses the treatment role with insulin and (or) angiotensin II receptor subtype-1 (AT1-R) blocker (ARB) on insulin receptor and endothelin-1 receptor subtype (ETA-R and ETB-R) regulation in rat hearts suffering from insulin-dependent d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f2146ce6f361a0dc73d36a3693187a
https://doi.org/10.1139/y07-012
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10
Effect of Systemic Insulin and Angiotensin II Receptor Subtype-1 Antagonist on Endothelin-1 Receptor Subtype(s) Regulation and Binding in Diabetic Rat Heart
Autor: Chehade N. Karam, Wael A Jaroudi, Julnar Usta, Nuha Nuwayri-Salti, Anwar B. Bikhazi, Samer M. Abdallah, Khalil M. Bitar, Roy E Abrahamian, Malek J Baasisri, Darine S Zwainy
Publikováno v: Endothelium. 12:225-231
This study reports on the regulation and remodeling role of endothelin-1 (ET-1) and its receptor subtypes, ET(A)-Rs/ET(B)-Rs, at the coronary endothelium (CE) and cardiomyocyte (CM) sites. It is carried out in normal and normotensive rats with strept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76d1608238707ab2d2b573c1389c09f
https://doi.org/10.1080/10623320500476450
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