Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Chegwidden, L"'
Autor:
Temko, D., Gool, I.C. van, Rayner, E., Glaire, M., Makino, S., Brown, M., Chegwidden, L., Palles, C., Depreeuw, J., Beggs, A., Stathopoulou, C., Mason, J., Baker, A.M., Williams, M., Cerundolo, V., Rei, M., Taylor, J.C., Schuh, A., Ahmed, A., Amant, F., Lambrechts, D., Smit, V.T.H.B.M., Bosse, T., Graham, T.A., Church, D.N., Tomlinson, I.
Publikováno v:
Journal of Pathology, 245(3), 283-296
Journal of pathology, 245(3), 283-296. John Wiley and Sons Ltd
The Journal of Pathology
Temko, D, Van Gool, I C, Rayner, E, Glaire, M, Makino, S, Brown, M, Chegwidden, L, Palles, C, Depreeuw, J, Beggs, A, Stathopoulou, C, Mason, J, Baker, A-M, Williams, M, Cerundolo, V, Rei, M, Taylor, J C, Schuh, A, Ahmed, A, Amant, F, Lambrechts, D, Smit, V T, Bosse, T, Graham, T A, Church, D N & Tomlinson, I 2018, ' Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response ', The Journal of Pathology, vol. 245, no. 3, pp. 283-296 . https://doi.org/10.1002/path.5081
Journal of pathology, 245(3), 283-296. John Wiley and Sons Ltd
The Journal of Pathology
Temko, D, Van Gool, I C, Rayner, E, Glaire, M, Makino, S, Brown, M, Chegwidden, L, Palles, C, Depreeuw, J, Beggs, A, Stathopoulou, C, Mason, J, Baker, A-M, Williams, M, Cerundolo, V, Rei, M, Taylor, J C, Schuh, A, Ahmed, A, Amant, F, Lambrechts, D, Smit, V T, Bosse, T, Graham, T A, Church, D N & Tomlinson, I 2018, ' Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response ', The Journal of Pathology, vol. 245, no. 3, pp. 283-296 . https://doi.org/10.1002/path.5081
Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle to late stages of tumourigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f2818dd8ec51574ecc992ecb4bb37de5
http://hdl.handle.net/1887/75545
http://hdl.handle.net/1887/75545
Autor:
Cross, W., Kovac, M., Mustonen, V., Temko, D., Davis, H., Baker, A.-M., Biswas, S., Arnold, R., Chegwidden, L., Gatenbee, C., Anderson, A.R., Koelzer, V.H., Martinez, P., Jiang, X., Domingo, E., Woodcock, D.J., Feng, Y., Kovacova, M., Maughan, T., Adams, R., Bach, S., Beggs, A., Brown, L., Buffa, F., Cazier, J.-B., Blake, A., Wu, C.-H., Chatzpili, E., Richman, S., Dunne, P., Harkin, P., Higgins, G., Hill, J., Holmes, C., Horgan, D., Kaplan, R., Kennedy, R., Lawler, M., Leedham, S., McDermott, U., McKenna, G., Middleton, G., Morton, D., Murray, G., Quirke, P., Salto-Tellez, M., Samuel, L., Schuh, A., Sebag-Montefiore, D., Seymour, M., Sharma, R., Sullivan, R., Tomlinson, I., West, N., Wilson, R., Jansen, M., Rodriguez-Justo, M., Ashraf, S., Guy, R., Cunningham, C., East, J.E., Wedge, D.C., Wang, L.M., Palles, C., Heinimann, K., Sottoriva, A., Graham, T.A., Tomlinson, I.P.M.
Publikováno v:
Cross, W, Kovac, M, Mustonen, V, Temko, D, Davis, H, Baker, A-M, Biswas, S, Arnold, R, Chegwidden, L, Gatenbee, C, Anderson, A R, Koelzer, V H, Martinez, P, Jiang, X, Domingo, E, Woodcock, D J, Feng, Y, Kovacova, M, Maughan, T, Adams, R, Bach, S, Beggs, A, Brown, L, Buffa, F, Cazier, J-B, Domingo, E, Blake, A, Wu, C-H, Chatzpili, E, Richman, S, Dunne, P, Harkin, P, Higgins, G, Hill, J, Holmes, C, Horgan, D, Kaplan, R, Kennedy, R, Lawler, M, Leedham, S, Maughan, T, McDermott, U, McKenna, G, Middleton, G, Morton, D, Murray, G, Quirke, P, Salto-Tellez, M, Samuel, L, Schuh, A, Sebag-Montefiore, D, Seymour, M, Sharma, R, Sullivan, R, Tomlinson, I, West, N, Wilson, R, Jansen, M, Rodriguez-Justo, M, Ashraf, S, Guy, R, Cunningham, C, East, J E, Wedge, D C, Wang, L M, Palles, C, Heinimann, K, Sottoriva, A, Leedham, S, Graham, T A & Tomlinson, I P M 2018, ' The evolutionary landscape of colorectal tumorigenesis ', Nature Ecology and Evolution . https://doi.org/10.1038/s41559-018-0642-z
Nature ecology & evolution
Nature ecology & evolution
The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome/exome sequencing of 24 benign and malignant colorectal tumours, we probe the evolutionary fit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ca8e66b8acd7d108cf45e67d5a470d
http://eprints.whiterose.ac.uk/139375/
http://eprints.whiterose.ac.uk/139375/
Akademický článek
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Autor:
Palles, C, Tomlinson, I, Chegwidden, L, Gharahkhani, P, MacGregor, S, Vaughan, TL, Schumacher, J, Jankowski, J, Fitzgerald, R, Gockel, I, Buas, M, Knapp, M, Noethen, MM, Becker, J, Pharaoh, P, Whiteman, DC
Esophageal adenocarcinoma (EA) is an often fatal cancer with rising incidence in the developed world. Barrett’s esophagus (BE) is a pre-cancerous metaplastic precursor of EA. We performed the first genome-wide association study (GWAS) meta-analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b2e26b9b62b3b7307ac57b09e129b200
https://doi.org/10.1016/s1470-2045(16)30240-6
https://doi.org/10.1016/s1470-2045(16)30240-6
Autor:
Palles, C, Tomlinson, I, Chegwidden, L, Gharahkhani, P, MacGregor, S, Vaughan, T, Schumacher, J, Jankowski, J, Fitzgerald, R, Gockel, I, Buas, M, May, A, Gerges, C, Anders, M, Becker, J, Kreuser, N, Noder, T, Venerito, M, Veits, L, Schmidt, T, Manner, H, Schmidt, C, Hess, T, Böhmer, A, Izbicki, J, Hölscher, A, Lang, H, Lorenz, D, Schumacher, B, Hackelsberger, A, Mayershofer, R, Pech, O, Vashist, Y, Ott, K, Vieth, M, Weismüller, J, Nöthen, M, Attwood, S, Barr, H, de Caestecker, J, Harrison, R, Love, S, MacDonald, D, Moayyed, P, Prenen, H, Watson, R, Iyer, P, Anderson, L, Bernstein, L, Chow, W, Hardie, L, Lagergren, J, Liu, G, Risch, H, Wu, A, Ye, W, Bird, N, Shaheen, N, Gammon, M, Corley, D, Caldas, C, Moebus, S, Knapp, M, Peters, W, Neuhaus, H, Rösch, T, Ell, C, Pharaoh, P, Whiteman, D
Publikováno v:
Lancet Oncology. 17(10)
Background Esophageal adenocarcinoma (EA) is one of the fastest rising cancers in western countries. Barrett’s Esophagus (BE) is the premalignant precursor of EA. However, only a subset of BE patients develop EA, which complicates the clinical mana
Autor:
Palles, C, Chegwidden, L, Li, X, Findlay, JM, Farnham, G, Giner, FC, Peppelenbosch, MP, Kovac, M, Adams, CL, Prenen, H, Briggs, S, Harrison, R, Sanders, S, MacDonald, D, Haigh, C, Tucker, A, Love, S, Nanji, M, Decaestecker, J, Ferry, D, Rathbone, B, Hapeshi, J, Barr, H, Moayyedi, P, Watson, P, Zietek, B, Maroo, N, Gay, L, Underwood, T, Boulter, L, McMurtry, H, Monk, D, Patel, P, Ragunath, K, Al Dulaimi, D, Murray, I, Koss, K, Veitch, A, Trudgill, N, Nwokolo, C, Rembacken, B, Atherfold, P, Green, E, Ang, Y, Kuipers, EJ, Chow, W, Paterson, S, Kadri, S, Beales, I, Grimley, C, Mullins, P, Beckett, C, Farrant, M, Dixon, A, Kelly, S, Johnson, M, Wajed, S, Dhar, A, Sawyer, E, Roylance, R, Onstad, L, Gammon, MD, Corley, DA, Shaheen, NJ, Bird, NC, Hardie, LJ, Reid, BJ, Ye, W, Liu, G, Romero, Y, Bernstein, L, Wu, AH, Casson, AG, Fitzgerald, R, Whiteman, DC, Risch, HA, Levine, DM, Vaughan, TL, Verhaar, AP, van den Brande, J, Toxopeus, EL, Spaander, MC, Wijnhoven, BPL, van der Laan, LJW, Krishnadath, K, Wijmenga, C, Trynka, G, McManus, R, Reynolds, JV, O'Sullivan, J, MacMathuna, P, McGarrigle, SA, Kelleher, D, Vermeire, S, Cleynen, I, Bisschops, R, Tomlinson, I, Jankowski, J
Publikováno v:
Gastroenterology, 148(2), 367-378. W.B. Saunders
Gastroenterology, 148(2), 367-378. W B SAUNDERS CO-ELSEVIER INC
Gastroenterology, 148(2), 367-378. W.B. Saunders Ltd
Gastroenterology, 148(2), 367-378. W B SAUNDERS CO-ELSEVIER INC
Gastroenterology, 148(2), 367-378. W.B. Saunders Ltd
Background & Aims\ud \ud Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6808971181ef312a5e61497f90ed4569
https://pure.eur.nl/en/publications/2726e687-9c36-4a31-b334-50ee7af8539b
https://pure.eur.nl/en/publications/2726e687-9c36-4a31-b334-50ee7af8539b
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Palles, C., Fotheringham, S., Chegwidden, L., Lucas, M., Mozolowski, G., Tomlinson, I., Kerr, D.
Publikováno v:
In Annals of Oncology June 2018 29 Supplement 5:v59-v60