Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Autor: Kearney, SE, Zahoránszky-Köhalmi, G, Brimacombe, KR, Henderson, MJ, Lynch, C, Zhao, T, Wan, KK, Itkin, Z, Dillon, C, Shen, M, Cheff, DM, Lee, TD, Bougie, D, Cheng, K, Coussens, NP, Dorjsuren, D, Eastman, RT, Huang, R, Iannotti, MJ, Karavadhi, S, Klumpp-Thomas, C, Roth, JS, Sakamuru, S, Sun, W, Titus, SA, Yasgar, A, Zhang, YQ, Zhao, J, Andrade, RB, Brown, MK, Burns, NZ, Cha, JK, Mevers, EE, Clardy, J, Clement, JA, Crooks, PA, Cuny, GD, Ganor, J, Moreno, J, Morrill, LA, Picazo, E, Susick, RB, Garg, NK, Goess, BC, Grossman, RB, Hughes, CC, Johnston, JN, Joullie, MM, Kinghorn, AD, Kingston, DGI, Krische, MJ, Kwon, O, Maimone, TJ, Majumdar, S, Maloney, KN, Mohamed, E, Murphy, BT, Nagorny, P, Olson, DE, Overman, LE, Brown, LE, Snyder, JK, Porco, JA, Rivas, F, Ross, SA, Sarpong, R, Sharma, I, Shaw, JT, Xu, Z, Shen, B, Shi, W, Stephenson, CRJ, Verano, AL, Tan, DS, Tang, Y, Taylor, RE, Thomson, RJ, Vosburg, DA, Wu, J, Wuest, WM, Zakarian, A, Zhang, Y, Ren, T, Zuo, Z, Inglese, J, Michael, S, Simeonov, A, Zheng, W, Shinn, P, Jadhav, A, Boxer, MB, Hall, MD, Xia, M, Guha, R

Publikováno v: Kearney, SE; Zahoránszky-Köhalmi, G; Brimacombe, KR; Henderson, MJ; Lynch, C; Zhao, T; et al.(2018). Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Central Science, 4(12), 1727-1741. doi: 10.1021/acscentsci.8b00747. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0vt658wh

Copyright © 2018 American Chemical Society. Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8f3748e2a73a8da6abbc39abbd196dad
http://www.escholarship.org/uc/item/0vt658wh

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.

Autor: Cheff DM; Early Translation Branch, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE, 171 77, Stockholm, Sweden., Cheng Q; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE, 171 77, Stockholm, Sweden., Guo H; Early Translation Branch, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States., Travers J; Early Translation Branch, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States., Klumpp-Thomas C; Early Translation Branch, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States., Shen M; Early Translation Branch, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States., Arnér ESJ; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE, 171 77, Stockholm, Sweden; Department of Selenoprotein Research and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary. Electronic address: elias.arner@ki.se., Hall MD; Early Translation Branch, National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States. Electronic address: hallma@mail.nih.gov.

Publikováno v: Redox biology [Redox Biol] 2023 Jul; Vol. 63, pp. 102719. Date of Electronic Publication: 2023 May 16.

Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities.

Autor: Cheff DM; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden., Muotri AR; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA, USA., Stockwell BR; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Chemistry, Columbia University, New York, NY, USA., Schmidt EE; Department of Microbiology and Immunology, Montana State University, Bozeman, MT, USA., Ran Q; Department of Cell Systems and Anatomy, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA.; Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX, USA., Kartha RV; Department of Experimental and Clinical Pharmacology, Center for Orphan Drug Research, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA., Johnson SC; Department of Neurology, University of Washington, Seattle, WA, USA.; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Mittal P; In-Depth Genomics, Bellevue, WA, USA., Arnér ESJ; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden.; Department of Selenoprotein Research, National Institute of Oncology, Budapest, 1521, Hungary., Wigby KM; Department of Pediatrics, Division of Genetics, San Diego and Rady Children's Hospital-San Diego, University of California, San Diego, CA, USA.; Rady Children's Institute for Genomic Medicine, San Diego, CA, USA., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA., Ramesh SK; CureGPX4.org, Seattle, WA, USA. sanath@GPX4.org.

Publikováno v: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Oct 23; Vol. 16 (1), pp. 446. Date of Electronic Publication: 2021 Oct 23.

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.

Autor: Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Urban DJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Mott BT; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Yang SM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Benavides GA; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Johnson MS; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Squadrito GL; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Brimacombe KR; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Cheff DM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zhu H; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Henderson MJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Pohida K; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Sulikowski GA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Dranow DM; Beryllium Discovery Corp., 7869 Day Road West, Bainbridge Island, Washington 98110, United States., Kabir M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Shah P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Padilha E; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Tao D; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Fang Y; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Christov PP; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Kim K; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Jana S; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Muttil P; College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States., Anderson T; College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States., Kunda NK; College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States., Hathaway HJ; College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States., Kusewitt DF; Dept of Pathology, University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, United States., Oshima N; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, United States., Cherukuri M; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, United States., Davies DR; Beryllium Discovery Corp., 7869 Day Road West, Bainbridge Island, Washington 98110, United States., Norenberg JP; College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States., Sklar LA; Dept of Pathology, University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, United States., Moore WJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States., Dang CV; Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Ludwig Institute for Cancer Research, New York, New York 10017, United States., Stott GM; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States., Neckers L; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, United States., Flint AJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States., Darley-Usmar VM; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Waterson AG; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10984-11011. Date of Electronic Publication: 2020 Sep 27.

Predictive models for estimating cytotoxicity on the basis of chemical structures.

Autor: Sun H; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, United States. Electronic address: hongmao.sun@nih.gov., Wang Y; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, United States., Cheff DM; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, United States., Hall MD; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, United States., Shen M; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, United States. Electronic address: min.shen@nih.gov.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 May 15; Vol. 28 (10), pp. 115422. Date of Electronic Publication: 2020 Mar 12.