Reaction of Thiosulfate Dehydrogenase with a Substrate Mimic Induces Dissociation of the Cysteine Heme Ligand Giving Insights into the Mechanism of Oxidative Catalysis.

Autor: Jenner LP; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, United Kingdom., Crack JC; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, United Kingdom., Kurth JM; Institut für Mikrobiologie & Biotechnologie, Friedrich Wilhelms Universität Bonn, D-53115Bonn, Germany., Soldánová Z; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, United Kingdom., Brandt L; Institut für Mikrobiologie & Biotechnologie, Friedrich Wilhelms Universität Bonn, D-53115Bonn, Germany., Sokol KP; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CambridgeCB2 1EW, United Kingdom., Reisner E; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CambridgeCB2 1EW, United Kingdom., Bradley JM; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, United Kingdom., Dahl C; Institut für Mikrobiologie & Biotechnologie, Friedrich Wilhelms Universität Bonn, D-53115Bonn, Germany., Cheesman MR; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, United Kingdom., Butt JN; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, NorwichNR4 7TJ, United Kingdom.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Oct 12; Vol. 144 (40), pp. 18296-18304. Date of Electronic Publication: 2022 Sep 29.

Heme ligation and redox chemistry in two bacterial thiosulfate dehydrogenase (TsdA) enzymes.

Autor: Jenner LP; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom., Kurth JM; Institut für Mikrobiologie & Biotechnologie, Rheinische Friedrich Wilhelms Universität Bonn, D-53115 Bonn, Germany., van Helmont S; Institut für Mikrobiologie & Biotechnologie, Rheinische Friedrich Wilhelms Universität Bonn, D-53115 Bonn, Germany., Sokol KP; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Reisner E; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Dahl C; Institut für Mikrobiologie & Biotechnologie, Rheinische Friedrich Wilhelms Universität Bonn, D-53115 Bonn, Germany., Bradley JM; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom justin.bradley@uea.ac.uk., Butt JN; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom j.butt@uea.ac.uk., Cheesman MR; Centre for Molecular and Structural Biochemistry, School of Chemistry and School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom m.cheesman@uea.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Nov 22; Vol. 294 (47), pp. 18002-18014. Date of Electronic Publication: 2019 Aug 29.

Redox-dependent control of i-Motif DNA structure using copper cations.

Autor: Abdelhamid MA; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; Centre for Molecular and Structural Biochemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Fábián L; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., MacDonald CJ; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Cheesman MR; Centre for Molecular and Structural Biochemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Gates AJ; Centre for Molecular and Structural Biochemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Waller ZA; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; Centre for Molecular and Structural Biochemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2018 Jul 06; Vol. 46 (12), pp. 5886-5893.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Autor: Chenge JT; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Duyet LV; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Swami S; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., McLean KJ; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Kavanagh ME; the Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Coyne AG; the Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Rigby SE; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Cheesman MR; the School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom, and., Girvan HM; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Levy CW; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Rupp B; the Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Strasse 10, 13125 Berlin, Germany., von Kries JP; the Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Strasse 10, 13125 Berlin, Germany., Abell C; the Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Leys D; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom., Munro AW; From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom, Andrew.Munro@Manchester.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Jan 27; Vol. 292 (4), pp. 1310-1329. Date of Electronic Publication: 2016 Dec 08.

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