Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Chee-Keng Ng"'
Publikováno v:
Parenteral Medications ISBN: 9780429201400
In the world of medicine, drugs that demonstrate improved treatment efficacy with reduced adverse side effects are highly desired. The need for improved and specific delivery to cells and tumors in vivo has taken center stage. This chapter discusses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e343b7a23f947d963253eaec75ca27
https://doi.org/10.1201/9780429201400-19
https://doi.org/10.1201/9780429201400-19
Comparative Nonclinical Assessments of the Proposed Biosimilar PF-05280586 and Rituximab (MabThera®)
Autor:
Chee-Keng Ng, Mark Collinge, Stephen A. Ploch, Zaher A. Radi, Susan Hurst, Niraj Tripathi, Joshua Arrington, Amy C. Shen, Gregory L. Finch, Michael W. Leach, Norimitsu Shirai, Anne M. Ryan, Sharon A. Sokolowski, Thomas Cummings, Sarah A. Stephenson
Publikováno v:
Toxicologic Pathology. 42:1069-1081
Comparative nonclinical studies were conducted with the proposed biosimilar PF-05280586 and rituximab-EU (MabThera®). In side-by-side analyses, peptide maps and complement-dependent cytotoxicity assay results were similar. Sexually-mature cynomolgus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132f69be7fa3b35c06337bbee62cfecf
https://doi.org/10.1177/0192623313520351
https://doi.org/10.1177/0192623313520351
Autor:
Beverly Ingram, Chee-Keng Ng, Lynne A. Bui, Ira Jacobs, Anne M. Ryan, Carol F. Kirchhoff, Susan Hurst, Gregory L. Finch
Publikováno v:
Drug discovery today. 20
Biosimilar development requires several steps: selection of an appropriate reference biologic, understanding the key molecular attributes of that reference biologic and development of a manufacturing process to match these attributes of the reference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1286b76b8a3efbffeb76c81259ce18
https://pubmed.ncbi.nlm.nih.gov/25912284
https://pubmed.ncbi.nlm.nih.gov/25912284
Autor:
Jason C. Rouse, Heyi Li, Toni Duffy, Jianming Mo, Kelly N. Toler, Thomas J. Porter, Chee-Keng Ng, Andrew Saati, Tonya Matlosz, Tanya Q. Shang, Xi Lin, Jennifer Schenk
Publikováno v:
Journal of pharmaceutical sciences. 103(7)
A highly robust hydrophilic interaction liquid chromatography (HILIC) method that involves both fluorescence and mass spectrometric detection was developed for profiling and characterizing enzymatically released and 2‐aminobenzamide (2‐AB)‐deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c187164acfaf4b9c15afdfdbc196c9
https://pubmed.ncbi.nlm.nih.gov/24840237
https://pubmed.ncbi.nlm.nih.gov/24840237
Autor:
James W. Poser, Jens Pohl, Andrea Y. Thompson, Robert C. Spiro, Robin Daverman, Mohammad A. Heidaran, Chee Keng Ng
Publikováno v:
e-biomed: The Journal of Regenerative Medicine. 1:121-135
Growth and differentiation factor-5 (GDF-5) is a divergent member of the TGF-β/bone morphogenetic protein (BMP) superfamily that is required for proper skeletal patterning and joint development in ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226b3b56bedcbdd91cdb5142a4944152
https://doi.org/10.1089/152489000420294
https://doi.org/10.1089/152489000420294
Autor:
Tanya Shang, Yin Luo, Jason C. Rouse, Stephen W. Raso, Thomas J. Porter, Chee-Keng Ng, John Steckert, Tatjana Matejic, Brian Nunnally
Appropriate and complete analysis and characterization of biopharmaceutical proteins are important to the control of their safety, purity, potency, stability, and overall quality. This chapter reviews the methodologies that are used to characterize i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6736f9654517223b0264d81562092121
https://doi.org/10.1016/b978-0-12-375680-0.00008-5
https://doi.org/10.1016/b978-0-12-375680-0.00008-5
Publikováno v:
Archives of Biochemistry and Biophysics. 298:70-79
Hyaluronan was shown to have the same turnover time as aggrecan in explant cultures of adult bovine articular cartilage. Inclusion of fetal calf serum in the culture medium resulted in a similar decrease in the rate of catabolism of both hyaluronan a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499922c312abd7d5e42c3ed419b3032f
https://doi.org/10.1016/0003-9861(92)90095-e
https://doi.org/10.1016/0003-9861(92)90095-e
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1135:309-317
Addition of 20% (v/v) fetal calf serum or insulin-like growth factor-I (IGF-I; 20 ng/ml) to the medium of explant cultures of adult articular cartilage resulted in an increased rate of synthesis of the three components of the proteoglycan aggregate-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e1c8237d0dbf8fa2eaf5928799d4c5
https://doi.org/10.1016/0167-4889(92)90236-5
https://doi.org/10.1016/0167-4889(92)90236-5
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1034:73-80
Bovine collateral ligament was found to have a water content of 67.5 +/- 2.5%, the tissue was highly collagenous containing 100.3 +/- 15.1 micrograms hydroxyproline/mg dry weight. Type I collagen was the major collagen present with small amounts of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956e4e5369def536e915c46bca0a6fec
https://doi.org/10.1016/0304-4165(90)90155-p
https://doi.org/10.1016/0304-4165(90)90155-p
Autor:
Donghua Yin, Ruifeng Li, Susan Hurst, Reginald Ewesuedo, Ira Jacobs, Anne M. Ryan, Charles Zacharchuk, Chee-Keng Ng, Michael W. Leach, Gregory L. Finch
Publikováno v:
Journal of Clinical Oncology. 33:618-618
618 Background: Trastuzumab, a humanized recombinant monoclonal antibody, targets HER2 and is approved for treatment of HER2-overexpressing breast and gastric cancers. PF-05280014 is being develope...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e30ade3014f88e1c24d1ea52779bab
https://doi.org/10.1200/jco.2015.33.15_suppl.618
https://doi.org/10.1200/jco.2015.33.15_suppl.618