Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Chee-Jian Pua"'
Autor:
Benjamin Ng, Kevin Y. Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim, Fathima F. Kuthubudeen, Yu-Ning Liu, An An Hii, Benjamin L. George, Anissa A. Widjaja, Enrico Petretto, Stuart A. Cook
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract In lung disease, persistence of KRT8-expressing aberrant basaloid cells in the alveolar epithelium is associated with impaired tissue regeneration and pathological tissue remodeling. We analyzed single cell RNA sequencing datasets of human i
Externí odkaz:
https://doaj.org/article/07484aadbfc741bd92d4fb8436b32283
Autor:
Lara Curran, BSc, Antonio De Marvao, PhD, Paolo Inglese, PhD, Kathryn McGurk, PhD, Adam Clement, PhD, Sean Zheng, Surui Li, PhD, Chee Jian Pua, BSc, Mit Shah, Mina Jafari, PhD, Pantazis Theotokis, PhD, Rachel Buchan, Sean Jurgens, Claire Raphael, PhD, John Baksi, PhD, Antonis Pantazis, PhD, Brian Halliday, PhD, Dudley Pennell, MD, PhD, Wenjia Bai, PhD, Calvin Chin, MD, PhD, Rafik Tadros, PhD, Connie Bezzina, PhD, Hugh Watkins, PhD, Stuart Cook, PhD, Sanjay Prasad, James Ware, PhD, Declan O'Regan, PhD
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss , Pp 100168- (2024)
Externí odkaz:
https://doaj.org/article/436056cfa5134bd4bec362e828088d5d
Autor:
Vivian Lee, Qishi Zheng, Desiree-Faye Toh, Chee Jian Pua, Jennifer A. Bryant, Chi-Hang Lee, Stuart A. Cook, Javed Butler, Javier Díez, A. Mark Richards, Thu-Thao Le, Calvin W. L. Chin
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundDiffuse interstitial myocardial fibrosis is a key common pathological manifestation in hypertensive heart disease (HHD) progressing to heart failure (HF). Angiotensin receptor–neprilysin inhibitors (ARNi), now a front-line treatment for H
Externí odkaz:
https://doaj.org/article/1b177e2affe24770b9f07cf919337730
Autor:
Thu-Thao Le, PhD, Benjamin Huang, MD, Chee Jian Pua, PhD, Vineet Tornekar, MD, Annette Schumacher-Maurer, MD, Desiree-Faye Toh, MSc, Jennifer Bryant, PhD, Briana Ang, BSc, Ben Corden, PhD, Sanjay K. Prasad, MD, Hak-Chiaw Tang, MBBS, Stuart A. Cook, MD, PhD, Calvin W.L. Chin, MD, PhD
Publikováno v:
JACC: Asia, Vol 1, Iss 2, Pp 218-226 (2021)
Background: Hypertrophic cardiomyopathy (HCM) is defined as left ventricular end-diastolic maximal wall thickness (WTMax) ≥15.0 mm, without accounting for ethnicity, sex, and body size. It is well-established that Asians have smaller hearts than do
Externí odkaz:
https://doaj.org/article/8d800728bfbd47f0ba5108a6c13f1a7f
Autor:
Thu-Thao Le, Jennifer Ann Bryant, Briana Wei Yin Ang, Chee Jian Pua, Boyang Su, Pei Yi Ho, Shiqi Lim, Weiting Huang, Phong Teck Lee, Hak Chiaw Tang, Chee Tang Chin, Boon Yew Tan, Stuart Alexander Cook, Calvin Woon-Loong Chin
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-9 (2020)
Abstract Objectives The imaging features of dilated cardiomyopathy (DCM) overlap with physiological exercise-induced cardiac remodeling in active and otherwise healthy individuals. Distinguishing the two conditions is challenging. This study examined
Externí odkaz:
https://doaj.org/article/ef3998389983473e8dfe87a941ff0f6a
Autor:
Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:739-754
Background: Marfan Syndrome (MFS) is an inherited connective tissue disorder caused by mutations in the FBN1 (fibrillin-1) gene. Lung abnormalities are common in MFS, but their pathogenesis is poorly understood. IL11 (interleukin-11) causes aortic di
Autor:
Nithin R. Iyer, Thu-Thao Le, Michelle S.L. Kui, Hak-Chiaw Tang, Chee-Tang Chin, Soon-Kieng Phua, Jennifer A. Bryant, Chee-Jian Pua, Briana Ang, Desiree-Faye Toh, Tar-Choon Aw, Chi-Hang Lee, Stuart A. Cook, Martin Ugander, Calvin W.L. Chin
Publikováno v:
Hypertension. 79:1804-1813
Background: The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear. Methods: REMODEL (Response of the Myocardium to Hypertrophic Conditions in the Adult Population) is an observati
Autor:
Upasana Tayal, Job A.J. Verdonschot, Mark R. Hazebroek, James Howard, John Gregson, Simon Newsome, Ankur Gulati, Chee Jian Pua, Brian P. Halliday, Amrit S. Lota, Rachel J. Buchan, Nicola Whiffin, Lina Kanapeckaite, Resham Baruah, Julian W.E. Jarman, Declan P. O’Regan, Paul J.R. Barton, James S. Ware, Dudley J. Pennell, Bouke P. Adriaans, Sebastiaan C.A.M. Bekkers, Jackie Donovan, Michael Frenneaux, Leslie T. Cooper, James L. Januzzi, John G.F. Cleland, Stuart A. Cook, Rahul C. Deo, Stephane R.B. Heymans, Sanjay K. Prasad
Publikováno v:
Journal of the American College of Cardiology, 79(22), 2219-2232. Elsevier Science
BACKGROUND: Dilated cardiomyopathy (DCM) is a final common manifestation of heterogenous etiologies. Adverse outcomes highlight the need for disease stratification beyond ejection fraction. OBJECTIVES: The purpose of this study was to identify novel,
Autor:
Chee Jian Pua, Germaine Loo, Michelle Kui, Wai Lun Moy, An-An Hii, Vivian Lee, Chee-Tang Chin, Jennifer A Bryant, Desiree-Faye Toh, Chi-Hang Lee, Stuart A Cook, A Mark Richards, Thu-Thao Le, Calvin WL Chin
BACKGROUNDCompared to patients with hypertension only (HTN), those with hypertension and diabetes (HTN/DM) have worse prognosis. We aimed to characterize morphological differences between HTN and HTN/DM using cardiovascular magnetic resonance (CMR);
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913007f11ece8940ab39bacc690f60a9
https://doi.org/10.1101/2023.03.27.23287819
https://doi.org/10.1101/2023.03.27.23287819
Autor:
Kathryn A. McGurk, Xiaolei Zhang, Pantazis Theotokis, Kate Thomson, Andrew Harper, Rachel J. Buchan, Erica Mazaika, Elizabeth Ormondroyd, William T. Wright, Daniela Macaya, Chee Jian Pua, Birgit Funke, Daniel G. MacArthur, Sanjay Prasad, Stuart A. Cook, Mona Allouba, Yasmine Aguib, Magdi H. Yacoub, Declan P. O’Regan, Paul J. R. Barton, Hugh Watkins, Leonardo Bottolo, James S. Ware
Understanding the penetrance of pathogenic variants identified as secondary findings (SFs) is of paramount importance with the growing availability of genetic testing. We estimated penetrance through large-scale analyses of patients referred for diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75738ceeb386549240e3ad0a8142aa93
https://doi.org/10.1101/2023.03.15.23287112
https://doi.org/10.1101/2023.03.15.23287112