Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Chee Wai Chua"'
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer
Autor:
Baijun Dong, Juju Miao, Yanqing Wang, Wenqin Luo, Zhongzhong Ji, Huadong Lai, Man Zhang, Xiaomu Cheng, Jinming Wang, Yuxiang Fang, Helen He Zhu, Chee Wai Chua, Liancheng Fan, Yinjie Zhu, Jiahua Pan, Jia Wang, Wei Xue, Wei-Qiang Gao
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Using single-cell RNA sequencing, Dong, Miao, Wang et al. profile the transcriptomes of 21,292 cells from biopsies of 6 castration-resistant prostate cancers. They find that all neuroendocrine tumor cells display a luminal-like epithelial phenotype,
Externí odkaz:
https://doaj.org/article/d4789977decd4a4196f4b021074be091
Autor:
Xue Wang, Haibo Xu, Chaping Cheng, Zhongzhong Ji, Huifang Zhao, Yaru Sheng, Xiaoxia Li, Jinming Wang, Yu Shu, Yuman He, Liancheng Fan, Baijun Dong, Wei Xue, Chee Wai Chua, Dongdong Wu, Wei-Qiang Gao, Helen He Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell
Externí odkaz:
https://doaj.org/article/bd8edfecd5cc4953a997a60f4c5ace58
Autor:
Chee Wai Chua, Nusrat J Epsi, Eva Y Leung, Shouhong Xuan, Ming Lei, Bo I Li, Sarah K Bergren, Hanina Hibshoosh, Antonina Mitrofanova, Michael M Shen
Publikováno v:
eLife, Vol 7 (2018)
Master regulatory genes of tissue specification play key roles in stem/progenitor cells and are often important in cancer. In the prostate, androgen receptor (AR) is a master regulator essential for development and tumorigenesis, but its specific fun
Externí odkaz:
https://doaj.org/article/cb375be9a2604443a71f9d6c7e3175fa
Autor:
Yong Zhang, Xian‐Li Song, Bin Yu, Lian‐Chee Foong, Yu Shu, Chun‐Wai Mai, Jing Hu, Baijun Dong, Wei Xue, Chee Wai Chua
Publikováno v:
International Journal of Urology. 29:1085-1094
TP53 loss-of-function is commonly found in aggressive prostate cancer. However, a highly-efficient therapy for this tumor subtype is still lacking. In this study, we investigated the relationship between TP53 mutation status and autophagy in prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b61f528db5fddc8cdc5b10fca507bb
https://doi.org/10.1111/iju.15021
https://doi.org/10.1111/iju.15021
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Index of Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400192d080ba228dd2401397762ff34b
https://doi.org/10.1158/2159-8290.22541971.v1
https://doi.org/10.1158/2159-8290.22541971.v1
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Supplementary Table 3: Transcriptomic analyses of the human patient samples A. TCGA Interactome B. SU2C Interactome C. Protein activity TCGA D. Protein Activity SU2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50152ab5715db26bd60d40e0922dd5e7
https://doi.org/10.1158/2159-8290.22541959
https://doi.org/10.1158/2159-8290.22541959
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Prioritizing treatments for individual patients with cancer remains challenging, and performing coclinical studies using patient-derived models in real time is often unfeasible. To circumvent these challenges, we introduce OncoLoop, a precision medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b855720c962afe23f44290b02652b77
https://doi.org/10.1158/2159-8290.c.6549772
https://doi.org/10.1158/2159-8290.c.6549772
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Detailed Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4df22845dfdcb9a0c8be4fd4916ec0
https://doi.org/10.1158/2159-8290.22541974
https://doi.org/10.1158/2159-8290.22541974
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Figure S1: Genomic alterations in prostate cancer represented in the GEMMs (related to Fig. 2). Figure S2: Additional phenotypic analyses of the GEMMs (related to Fig. 2). Figure S3: Phenotypic analysis of allograft and organoid models (related to Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadb434fc053ed576194fbc4dad00257
https://doi.org/10.1158/2159-8290.22541968
https://doi.org/10.1158/2159-8290.22541968
Autor:
Cory Abate-Shen, Hikmat A. Al-Ahmadie, Michael M. Shen, David B. Solit, James M. McKiernan, Talal Syed, Prithi Chakrapani, Amir Lankarani, Jaime Y. Kim, Chee-Wai Chua, Rivka L. Shoulson, Matteo Di Bernardo, Tomasz B. Owczarek, Lijie Rong, Soonbum Park
Video of mouse procedures for post-surgical steps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62101f853d954f4e6d6e4b7f24cd93f7
https://doi.org/10.1158/0008-5472.22431193.v1
https://doi.org/10.1158/0008-5472.22431193.v1