Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Chee Onn Leong"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cancer cells are constantly evolving to adapt to environmental changes, particularly during exposure to drug treatment. In this work, we aimed to characterize genetic and epigenetic changes in mitochondrial DNA (mtDNA) that may increase the
Externí odkaz:
https://doaj.org/article/a774cd9922ea4ef7a8f79297b528fc45
Autor:
Yuen-Fen Tan, Ling-Wei Hii, Wei-Meng Lim, Soon-Keng Cheong, Chee-Onn Leong, Maxine Swee-Li Yee, Chun-Wai Mai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Small interfering RNAs (siRNA) technology has emerged as a promising therapeutic tool for human health conditions like cancer due to its ability to regulate gene silencing. Despite FDA-approved, their delivery remains localized and limiting
Externí odkaz:
https://doaj.org/article/83a087deae414d62bd0ac074327afb1f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/e5787312e3694be7b5c005cc801159a1
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy that raises public health concerns in endemic countries. Despite breakthroughs in therapeutic strategies, late diagnosis and drug resistance often lead to unsatisfactory clinical outcomes in
Externí odkaz:
https://doaj.org/article/1ad6b067c94f42b7b1f29a952171afe7
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine. Two distinct SPHK isoforms, namely SPHK1 and SPHK2, have been identified to dat
Externí odkaz:
https://doaj.org/article/b512e9fc0b7346868f266b6c6bee4419
Autor:
Ling-Wei Hii, Swee-Hua Erin Lim, Chee-Onn Leong, Swee-Yee Chin, Ngai-Paing Tan, Kok-Song Lai, Chun-Wai Mai
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Clinacanthus nutans extracts have been consumed by the cancer patients with the hope that the extracts can kill cancers more effectively than conventional chemotherapies. Our previous study reported its anti-inflammatory effects w
Externí odkaz:
https://doaj.org/article/f16972e005df40e48d15800f3832dafa
Autor:
Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli, Chun-Wai Mai
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-23 (2019)
Abstract Background Pancreatic cancer is one of the most lethal type of cancers, with an overall five-year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited therapeutic options. To date, no effective treatment o
Externí odkaz:
https://doaj.org/article/d9cc73b40e2c4c40890540f86771ffd2
Advances in Nanomaterials Used in Co-Delivery of siRNA and Small Molecule Drugs for Cancer Treatment
Autor:
Shei Li Chung, Maxine Swee-Li Yee, Ling-Wei Hii, Wei-Meng Lim, Mui Yen Ho, Poi Sim Khiew, Chee-Onn Leong
Publikováno v:
Nanomaterials, Vol 11, Iss 10, p 2467 (2021)
Recent advancements in nanotechnology have improved our understanding of cancer treatment and allowed the opportunity to develop novel delivery systems for cancer therapy. The biological complexities of cancer and tumour micro-environments have been
Externí odkaz:
https://doaj.org/article/efcbaa2990b4412f95b86e1ffc4043d6
Autor:
Wei Xiong Wen, Chee-Onn Leong
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215381 (2019)
Immune checkpoint inhibitors have demonstrated effective anti-tumour response in cancer types with high mutation burden (e.g. melanoma) and in subset of cancers with features of genomic instability (e.g. mismatch-repair deficiency). One possible expl
Externí odkaz:
https://doaj.org/article/11e073cb8cad4323a9373739cf238912
Autor:
Chee-Onn Leong, Malcolm F.G. Stevens, Tracey D. Bradshaw, Heng Lungh Choo, Nirmal Randhawa, Ashwin Muruhadas, Kai Hung Tiong, Boon Shing Tan
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c0e9465ad4a531af2ba888341fb366
https://doi.org/10.1158/1535-7163.22496415.v1
https://doi.org/10.1158/1535-7163.22496415.v1
