Výsledky vyhledávání - "Chee Man Cheong"

Akademický článek

The expression and role of the Lem-D proteins Ankle2, Emerin, Lemd2, and TMPO in triple-negative breast cancer cell growth

Autor: Maddison Rose, Joshua T. Burgess, Chee Man Cheong, Mark N. Adams, Parastoo Shahrouzi, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundTriple-negative breast cancer (TNBC) is a sub-classification of breast carcinomas, which leads to poor survival outcomes for patients. TNBCs do not possess the hormone receptors that are frequently targeted as a therapeutic in other cancer

Externí odkaz: https://doaj.org/article/730fd40bf05e413cbdb093bdcca0200a

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Akademický článek

The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair

Autor: Thais Sobanski, Amila Suraweera, Joshua T. Burgess, Iain Richard, Chee Man Cheong, Keyur Dave, Maddison Rose, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A (ALDOA) protein in DNA double-strand break (DSB) repair. ALDOA is a

Externí odkaz: https://doaj.org/article/a81c8e487a144595879ce2d50a37a29b

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Akademický článek

The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function

Autor: Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T. Burgess, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi, Emma Bolderson

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Barrier-to-Autointegration Factor 1 (Banf1/BAF) is a critical component of the nuclear envelope and is involved in the maintenance of chromatin structure and genome stability. Banf1 is a small DNA binding protein that is conserved amongst multicellul

Externí odkaz: https://doaj.org/article/b1de3dd79957471790866e59707c6fb6

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Akademický článek

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

Autor: Krzysztof Marek Mrozik, Orest William Blaschuk, Chee Man Cheong, Andrew Christopher William Zannettino, Kate Vandyke

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)

Abstract In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype. This transition endows tu

Externí odkaz: https://doaj.org/article/c50a6da34691438c9b9311c5af0cfeab

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