Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Checkpoint signalling"'
Autor:
Yaoqin Gong, Limei Xu, Qiao Liu, Tingting Yang, Jing Wang, Xiyu Zhang, Guosheng Lv, Wenqing Bu, Changshun Shao, Xiaojie Liu, Dong Hou, Xiaohe Hao
Publikováno v:
Oncogene
Reactive oxygen species (ROS) serve as critical signals in various cellular processes. Excessive ROS cause cell death or senescence and mediates the therapeutic effect of many cancer drugs. Recent studies showed that ROS increasingly accumulate durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f03d752481f0cb732e4167da024e3d
http://europepmc.org/articles/PMC8755538
http://europepmc.org/articles/PMC8755538
Publikováno v:
Cell Death and Disease, Vol 11, Iss 6, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
Nuclear envelope component PRR14 has been detected to be upregulated in varieties of cancers, especially in breast cancer. But its role in breast carcinogenesis is poorly understood. In this study, we show PRR14 contributes to breast carcinogenesis m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c902701c92ce76c20bd505d38c792f0
http://link.springer.com/article/10.1038/s41419-020-2640-8
http://link.springer.com/article/10.1038/s41419-020-2640-8
Autor:
Chunsun Dai, Qi Yuan, Jiao Miao, Lei Jiang, Junwei Yang, Ke Zen, Qianqian Yang, Hao Ding, Yi Fang, Qi Sun, Yang Zhou, Li Fang
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
Podocytes, a type of highly specialized epithelial cells, require substantial levels of energy to maintain glomerular integrity and function, but little is known on the regulation of podocytes’ energetics. Lack of metabolic analysis during podocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92a0cf870af04e619a8849abf3d4a77
http://link.springer.com/article/10.1038/s41419-020-2481-5
http://link.springer.com/article/10.1038/s41419-020-2481-5
Publikováno v:
Cell Research
Co-inhibitory receptors are important regulators of T-cell function that define the balance between tolerance and autoimmunity. The immune regulatory function of co-inhibitory receptors, including CTLA-4, PD-1, TIM-3, TIGIT, and LAG-3, was first disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10873afaa42c39d813c208d82e3dd86d
http://europepmc.org/articles/PMC7118128
http://europepmc.org/articles/PMC7118128
Autor:
Ruth H. Palmer, Joachim T. Siaw, Badrul Arefin, Yeshwant Kurhe, Jimmy Van den Eynden, Arne Claeys, Ganesh Umapathy, Bengt Hallberg, Jonatan L Gabre, Joanna Szydzik, Dan E. Lind
Publikováno v:
NATURE COMMUNICATIONS
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes like MYCN and ALK result in increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e182496a6f30278939a789f0e8eb7
https://doi.org/10.1038/s41467-021-27057-2
https://doi.org/10.1038/s41467-021-27057-2
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)
While their function, as immune checkpoint molecules, is well known, B7-family proteins also function as regulatory molecules in bone remodeling. B7–H3 is a receptor ligand of the B7 family that functions primarily as a negative immune checkpoint.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300ee9f2b670a4a6007635dc19fd2344
http://europepmc.org/articles/PMC8528854
http://europepmc.org/articles/PMC8528854
Autor:
Li, Linli, Li, Hailong, He, Yiqun, Tang, Han, Dong, Jian, Chen, Xujun, Lyu, Feizhou, Dong, Youhai
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Mechanical loads are fundamental regulators of bone formation and remodeling. However, the molecular regulation of mechanotransduction during vertebral laminae regeneration remains poorly understood. Here, we found that cerebrospinal fluid pulsation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa09124271f44529b5bed8ef0ee31411
https://doi.org/10.1038/s41536-021-00164-w
https://doi.org/10.1038/s41536-021-00164-w
Autor:
Jizhong Cheng, Christie M. Ballantyne, Luge Li, Xinchun Pi, Hua Mao, Dimuthu Perera, Zheng Sun, Liang Xie, Pradip K. Saha, Huaizhu Wu, Cristian Coarfa, Kimal Rajapakshe, Aude Angelini, Qiying Fan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The vascular endothelium is present within metabolic organs and actively regulates energy metabolism. Here we show osteocalcin, recognized as a bone-secreted metabolic hormone, is expressed in mouse primary endothelial cells isolated from heart, lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a60ebb71e9e642e7c0d9283df3ba93
https://doi.org/10.1038/s41467-021-25673-6
https://doi.org/10.1038/s41467-021-25673-6
Autor:
Rui-Ming Yan, Wei Wang, Wen-Fei Wei, Luo-Jiao Liang, Mei Zhong, Sha Wu, Li Liang, Xiao-Jing Chen, Yan-Mei Zhang, Zi-Ci Wang, Yuan-Run Deng, Chen-Fei Zhou
Publikováno v:
Cell Death and Disease, Vol 10, Iss 7, Pp 1-11 (2019)
Cell Death & Disease
Cell Death & Disease
The accumulation of tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is associated with malignant progression in cancer. However, the mechanisms by which the hypoxic TME facilitates TAM infiltration are not fully unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602504ef2b28a8d7887b9a6c45894da9
http://link.springer.com/article/10.1038/s41419-019-1748-1
http://link.springer.com/article/10.1038/s41419-019-1748-1
Autor:
Da-Mi Kim, Ju-Won Jang, You-Soub Lee, Soo-Hyun Song, Suk-Chul Bae, Jung-Won Lee, Jin-Won Hyun, Yoshiaki Ito, Xin-Zi Chi, Tae-Geun Park, Il Yeong Park
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
The cellular decision regarding whether to undergo proliferation or death is made at the restriction (R)-point, which is disrupted in nearly all tumors. The identity of the molecular mechanisms that govern the R-point decision is one of the fundament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4462c90fa469e982ae8dd326d0d277f
https://doaj.org/article/ce5cd98dd35b4a8b97f2416472079307
https://doaj.org/article/ce5cd98dd35b4a8b97f2416472079307