Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Chean Eng, Ooi"'
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Akademický článek
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers
Autor: Aurélien Marabelle, Aung Naing, Funda Meric-Bernstam, Xingfeng Bao, Andrea Varga, David S Hong, Aparna Parikh, Geoffrey I Shapiro, Özlem Ataman, Larisa Reyderman, Terri A Binder, Min Ren, Mingjie Liu, Satish Dayal, Amy Y Siu, Pallavi Sachdev, Lucy Xu, Vijay Bhagawati-Prasad, Ilian Tchakov, Chean Eng Ooi
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background E7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safet
Externí odkaz: https://doaj.org/article/e224332c09c046d89e9e666fa3f6b4e3
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4
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE
Autor: David S, Hong, Aparna, Parikh, Geoffrey I, Shapiro, Andrea, Varga, Aung, Naing, Funda, Meric-Bernstam, Özlem, Ataman, Larisa, Reyderman, Terri A, Binder, Min, Ren, Mingjie, Liu, Satish, Dayal, Amy Y, Siu, Pallavi, Sachdev, Lucy, Xu, Vijay, Bhagawati-Prasad, Ilian, Tchakov, Chean Eng, Ooi, Xingfeng, Bao, Aurelien, Marabelle
Publikováno v: Journal for Immunotherapy of Cancer
Background E7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::145fdac8f1ef2ea42f708c1157066faa
https://pubmed.ncbi.nlm.nih.gov/32554609
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5
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers
Autor: Pallavi Sachdev, Amy Siu, Xingfeng Bao, Geoffrey I. Shapiro, Aung Naing, Vijay Bhagawati-Prasad, O. Ataman, Aurélien Marabelle, Lucy Xu, David S. Hong, Larisa Reyderman, Terri A. Binder, Satish Dayal, Andrea Varga, Aparna Raj Parikh, Mingjie Liu, Funda Meric-Bernstam, Ilian Tchakov, Min Ren, Chean Eng Ooi
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundE7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safety
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a926ef25c1c8bbba411f7030246ddd5b
https://doi.org/10.1136/jitc-2019-000222
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7
An Ear-Core Interaction Regulates the Recruitment of the AP-3 Complex to Membranes
Autor: Stephane Lefrancois, Markus Boehm, Katy Janvier, Chean Eng Ooi, Juan S. Bonifacino
Publikováno v: Developmental Cell. 7:619-625
AP-3 is a heterotetrameric adaptor involved in the biogenesis of lysosome-related organelles. The function of AP-3 as an adaptor relies on its ability to bind to membranes in an Arf-dependent fashion and to recognize sorting signals in the cytosolic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fad67a896d7679a56c880644f340c8e
https://doi.org/10.1016/j.devcel.2004.08.009
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8
ADP-Ribosylation Factor 1 (ARF1) Regulates Recruitment of the AP-3 Adaptor Complex to Membranes
Autor: Juan S. Bonifacino, Esteban C. Dell'Angelica, Chean Eng Ooi
Publikováno v: The Journal of Cell Biology
Small GTP-binding proteins such as ADP- ribosylation factor 1 (ARF1) and Sar1p regulate the membrane association of coat proteins involved in intracellular membrane trafficking. ARF1 controls the clathrin coat adaptor AP-1 and the nonclathrin coat CO
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee072a90a88ba45521cb46c467b6b7a
https://doi.org/10.1083/jcb.142.2.391
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9
Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis
Autor: Richard D. Klausner, Chean Eng Ooi, Juan S. Bonifacino, E. Rabinovich, Andrew Dancis
Publikováno v: Scopus-Elsevier
The cell surface protein repertoire needs to be regulated in response to changes in the extracellular environment. In this study, we investigate protein turnover of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p, in response to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5e9b1e0cac7f35ef972f2f5991fba2
https://doi.org/10.1002/j.1460-2075.1996.tb00720.x
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10
Phase 1 study of E7046, an inhibitor of the PGE2 receptor EP-4, that targets immunosuppressive myeloid cells in the tumor microenvironment (NCT02540291)
Autor: Chean Eng Ooi, Matthew Guo, David S. Hong, O. Ataman, Eunice L. Kwak, Aurélien Marabelle
Publikováno v: Journal of Clinical Oncology. 34:e14116-e14116
e14116Background: Tumor-associated host myeloid cells can be either antitumor (eg, type 1 macrophages, mature antigen-presenting cells) or immunosuppressive pro-tumor (eg, type 2 macrophages, myelo...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51dfe03762d7723536c8225ac341e5a4
https://doi.org/10.1200/jco.2016.34.15_suppl.e14116
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