Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Cheah Chen Seh"'
Autor:
Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic act
Externí odkaz:
https://doaj.org/article/9bed2e761e8c4eac932cd102650b701a
Autor:
Lindsay Kua, Chee Hoe Ng, Jin Wei Tan, Richard Ong, Cheah Chen Seh, Fiona Wong, Don Sim, Ivan David Horak, Lionel Low, Kar Wai Tan
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Autor:
Cheah Chen Seh, Chong Wai Liew, Pei Yong Shi, Gang Wang, Christian G. Noble, Timothy E. Benson, Tingjin Sherryl Soh, Thomas M. Smith, Fumiaki Yokokawa, Julien Lescar, Rishi Arora, Kimberley Yue, Siew Pheng Lim, Yen Liang Chen, Dorcas Adobea Otoo, Shahul Nilar
Publikováno v:
J Virol
Dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRp), an important drug target, synthesizes viral RNA and is essential for viral replication. While a number of allosteric inhibitors have been reported for hepatitis C virus RdRp, few have been
Autor:
Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen
Publikováno v:
Antimicrob Agents Chemother
Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/
https://europepmc.org/articles/PMC7674056/
Autor:
Wei Liu, Sreehari Babu, Wai Ling Chan, Suresh B. Lakshminarayana, Ellena Growcott, Peck Gee Seah, Martijn Fenaux, Mei Ding, Nahdiyah Abdul Ghafar, Gang Wang, Ratna Karuna, Cheah Chen Seh, Haoying Xu, Feng Gu, Weidong Zhong, Pei Yong Shi, Keshi Wang, Andrea Leonardi, Francesca Blasco, Yen Liang Chen, Srinivasa P. S. Rao, Siew Pheng Lim, Fumiaki Yokokawa, Jin Zhang
Monophosphate prodrug analogs of 2’-deoxy-2’-fluoro-2’-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue activities in cellular assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d10b314ef2182303dfcf7c75456ce
Autor:
Tingjin Sherryl Soh, Siew Pheng Lim, Pei Yong Shi, Aïcha Gharbi-Ayachi, Cheah Chen Seh, Abbas El Sahili, Jonas Schiltz, Julien Lescar
Publikováno v:
J Virol
Flavivirus nonstructural protein 5 (NS5) contains an N-terminal methyltransferase (MTase) domain and a C-terminal polymerase (RNA-dependent RNA polymerase [RdRp]) domain fused through a 9-amino-acid linker. While the individual NS5 domains are struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f922d878aeb3ed12eb10bde651dc091f
https://europepmc.org/articles/PMC6912093/
https://europepmc.org/articles/PMC6912093/
Autor:
Pei Yong Shi, Fumiaki Yokokawa, Rishi Arora, Cheah Chen Seh, Timothy E. Benson, Siew Pheng Lim, Paul W. Smith, Shahul Nilar, S. Kirk Wright, Christian G. Noble
Publikováno v:
Journal of Biological Chemistry. 291:8541-8548
We performed a fragment screen on the dengue virus serotype 3 RNA-dependent RNA polymerase using x-ray crystallography. A screen of 1,400 fragments in pools of eight identified a single hit that bound in a novel pocket in the protein. This pocket is
Autor:
Ranga Rao, Jürg Hunziker, Siew Pheng Lim, Haoying Xu, Oliver L. Saunders, Yen Liang Chen, Xiaodong Lin, Feng Gu, Weidong Zhong, Cheah Chen Seh, Gang Wang, Pei Yong Shi, Martijn Fenaux, Katherine Chan, Fumiaki Yokokawa, Nahdiyah Abdul Ghafar
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(13)
To identify a potent and selective nucleoside inhibitor of dengue virus RNA-dependent RNA polymerase, a series of 2'- and/or 4'-ribose sugar modified uridine nucleoside phosphoramidate prodrugs and their corresponding triphosphates were synthesized a
Autor:
Fumiaki Yokokawa, Kah Fei Wan, Tingjin Sherryl Soh, Julien Lescar, Timothy E. Benson, Shahul Nilar, Ujjini H. Manjunatha, Christian G. Noble, Rishi Arora, Pei Yong Shi, Siew Pheng Lim, Xuping Xie, Abbas El Sahili, Grace Kar Yarn Chan, Cheah Chen Seh, Hongping Dong
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
PLoS Pathogens, Public Library of Science, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034136f5f16028951bdce66f86164cb2
https://hal.sorbonne-universite.fr/hal-01393322
https://hal.sorbonne-universite.fr/hal-01393322