Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Che-Pei Kung"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/dafadf00f8c54eee8e10ba61b9ce044e
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/08450fb51f154574ad1b6f4618c0cb08
Autor:
Che-Pei Kung, Jason D. Weber
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic stresses, are our bodies’ greatest weapons to battle against cancer onset and development. Consequently, factors that possess significant p53-regulating activities hav
Externí odkaz:
https://doaj.org/article/601d69ae18234fac8f2b99d42deb97ff
Autor:
Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce V Lee, William J Quinn, Che-Pei Kung, Rexford Ahima, Joseph A Baur, Kathryn E Wellen, Qin Liu, Zachary T Schug, Donna L George, Maureen E Murphy
Publikováno v:
eLife, Vol 9 (2020)
The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased cancer risk in humans and mice. Due to impaired repression of the cystine importer Slc7a11, S47 cells show increased glutathione (GSH) accumulati
Externí odkaz:
https://doaj.org/article/c17ed4ebd0124f678260df2ab091b171
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/b97085c6d5c043c793e1f0c32e0d3e2c
Publikováno v:
eLife, Vol 8 (2019)
Proliferating cells often have increased glucose consumption and lactate excretion relative to the same cells in the quiescent state, a phenomenon known as the Warburg effect. Despite an increase in glycolysis, however, here we show that non-transfor
Externí odkaz:
https://doaj.org/article/e65f61cec7b345d382006736cb79f515
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years
Externí odkaz:
https://doaj.org/article/e91137ce2f7747c3875ec60fa2250a89
Autor:
Che-Pei Kung, Julia I-Ju Leu, Subhasree Basu, Sakina Khaku, Frederick Anokye-Danso, Qin Liu, Donna L. George, Rexford S. Ahima, Maureen E. Murphy
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2413-2425 (2016)
p53 is well known for its tumor suppressor role, but this protein also has a poorly understood role in the regulation of metabolism. Human studies have implicated a common polymorphism at codon 72 of p53 in diabetic and pre-diabetic phenotypes. To un
Externí odkaz:
https://doaj.org/article/cd66e87c89924d80898655f20d639f64
Autor:
Keerthana Gnanapradeepan, Subhasree Basu, Thibaut Barnoud, Anna Budina-Kolomets, Che-Pei Kung, Maureen E. Murphy
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The p53 tumor suppressor continues to be distinguished as the most frequently mutated gene in human cancer. It is widely believed that the ability of p53 to induce senescence and programmed cell death underlies the tumor suppressor functions of p53.
Externí odkaz:
https://doaj.org/article/ba7900fa0bdd4d24b37e3538622d8c34
Autor:
Che-Pei Kung, Emily Bross, Emily Bramel, Eric Freeman, Thwisha Sabloak, Catherine Kuzmicki, Mike Benjamin, Leonard Maggi, Jason Weber
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 25-26 (2019)
OBJECTIVES/SPECIFIC AIMS: Triple-negative breast cancer (TNBC) accounts for one-fifth of the breast cancer patient population. The heterogeneous nature of TNBC and lack of options for targeted therapy make its treatment a constant challenge. The co-d
Externí odkaz:
https://doaj.org/article/7f82e7fce2d64538b165dc4efefec51f