Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Che Ma"'
Autor:
Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Cheng-Pin Chen, Shu-Hsing Cheng, Wen-Hsin Lee, Yu-Chi Chou, Alain R Townsend, Che Ma, Kuan-Ying A Huang
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012246 (2024)
Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from vaccinated and infected individuals and elucidate the mechanism of action of broadly neutraliz
Externí odkaz:
https://doaj.org/article/6b2ca9b4f9fe4182828d175f566a58ee
Autor:
Shiou-Chih Hsu, Kun-Hsien Lin, Yung-Chieh Tseng, Yang-Yu Cheng, Hsiu-Hua Ma, Ying-Chun Chen, Jia-Tsrong Jan, Chung-Yi Wu, Che Ma
Publikováno v:
Vaccines, Vol 12, Iss 6, p 569 (2024)
An incomplete Freund’s adjuvant elicited an overt pathogenesis in vaccinated mice following the intranasal challenge of A/California/07/2009 (H1N1) virus despite the induction of a higher specific antibody titer than other adjuvanted formulations.
Externí odkaz:
https://doaj.org/article/d17f26fc2c5c4ce69acf0dcfc0b1c176
Autor:
Hong Thuy Vy Nguyen, Xiaorui Chen, Claudia Parada, An-Chi Luo, Orion Shih, U-Ser Jeng, Chia-Ying Huang, Yu-Ling Shih, Che Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The FtsB-FtsL-FtsQ complex is essential for regulating cell wall synthesis during bacterial cell division. Here, authors report the full-length trimeric structure showing a tilted V-shaped conformation and suggest an allosteric regulatory mechanism.
Externí odkaz:
https://doaj.org/article/ea9125c01b5f4c17b41219e5cbe79619
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
Autor:
Kuan-Ying A. Huang, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K. Vester, Rory A. Hills, Mark Howarth, Jennifer R. Keeffe, Alexander A. Cohen, Leesa M. Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J. Bjorkman, Alain R. Townsend, Che Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
An antibody, IY-2A, identified from a panel of class-4 SARS-CoV-2-neutralizing antibodies isolated from convalescent and vaccinated individuals, targets and induces partial unfolding of a conserved epitope within the RBD. IY-2A retains activity again
Externí odkaz:
https://doaj.org/article/4fd4ed3b1b214dcab49cfc9d3f96eda6
Autor:
Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. Townsend
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12 (2021)
Externí odkaz:
https://doaj.org/article/07994aa424a748049a6a28635621c19d
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-11 (2020)
Abstract Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with extensive monitoring and annual refor
Externí odkaz:
https://doaj.org/article/c26509dd971b46eb9e66c0c29ba60399
Autor:
Yi-An Ko, Yueh-Hsiang Yu, Yen-Fei Wu, Yung-Chieh Tseng, Chia-Lin Chen, King-Siang Goh, Hsin-Yu Liao, Ting-Hua Chen, Ting-Jen Rachel Cheng, An-Suei Yang, Chi-Huey Wong, Che Ma, Kuo-I Lin
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8 (2021)
Hemagglutinin (HA) is the immunodominant protein of the influenza virus. We previously showed that mice injected with a monoglycosylated influenza A HA (HAmg) produced cross-strain-reactive antibodies and were better protected than mice injected with
Externí odkaz:
https://doaj.org/article/74ae43827c054dd89beda4ed1ea0e547
Autor:
Kuan-Ying A Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S Daniels, John W McCauley, Pramila Rijal, Alain R Townsend
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009352 (2021)
Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different clinical severities. Potent humoral responses were detected within 3 weeks of onset of illness
Externí odkaz:
https://doaj.org/article/7e9ce5b081804c2fbe263952aa0c1f4f
Autor:
Rakesh Kulkarni, Wen-Ching Chen, Ying Lee, Chi-Fei Kao, Shiu-Lok Hu, Hsiu-Hua Ma, Jia-Tsrong Jan, Chun-Che Liao, Jian-Jong Liang, Hui-Ying Ko, Cheng-Pu Sun, Yin-Shoiou Lin, Yu-Chiuan Wang, Sung-Chan Wei, Yi-Ling Lin, Che Ma, Yu-Chan Chao, Yu-Chi Chou, Wen Chang
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257191 (2021)
COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of coronaviruses. SARS-CoV-2 causes severe respiratory illness in 10-15% of infected individuals and mortality in 2-3%. Vacci
Externí odkaz:
https://doaj.org/article/6a4e62dbbd994a8fa9659f32ad19f2bf
Publikováno v:
Vaccines, Vol 10, Iss 2, p 163 (2022)
Immune checkpoint inhibitors such as monoclonal antibodies (mAbs) are amongst the most important breakthroughs in cancer therapeutics. However, high cost and short acting time limits its affordability and clinical application. Therefore, an economica
Externí odkaz:
https://doaj.org/article/da3096ea5167480fb60c8e95c6650c90