Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Che Leung Law"'
Autor:
Che-Leung Law, Dennis R. Benjamin, Lori Westendorf, Xinqun Zhang, Germein Linares, Ivan J. Stone, Mechthild Jonas, Michelle Ulrich, Fu Li
The primary mechanism of antibody–drug conjugates (ADC) is targeted delivery of a cytotoxic payload to tumor cells via cancer-associated membrane receptors. However, the tumor microenvironment likely plays a role in ADC penetration, distribution, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60535f598f017fba5fe5815d0e67e54e
https://doi.org/10.1158/1535-7163.c.6539563
https://doi.org/10.1158/1535-7163.c.6539563
Autor:
Che-Leung Law, Dennis R. Benjamin, Lori Westendorf, Xinqun Zhang, Germein Linares, Ivan J. Stone, Mechthild Jonas, Michelle Ulrich, Fu Li
Legends of supplementary Figure S1, S2 and S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed69dd0cf4638d7221e966054f3c81b
https://doi.org/10.1158/1535-7163.22510279
https://doi.org/10.1158/1535-7163.22510279
Autor:
Dennis R. Benjamin, Eric J. Feldman, Che-Leung Law, Peter D. Senter, Sa A. Wang, Maitrayee Goswami, Timothy S. Lewis, Mechthild Jonas, Weiping Zeng, Ivan J. Stone, Martha E. Anderson, Michelle Ulrich, Kerry Klussman, Django Sussman, Ashley Cronkite, Lucy Pan, John Valliere-Douglass, Lori Westendorf, Roland B. Walter, Changpu Yu, May Kung Sutherland, Fu Li
Gating strategy, primary AML cytotoxicity assay,additional cell liens for pH2AX assay and caspase assay, and h7G3ec antibody sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6621500ceec28e5ffa45ca4f5d714e
https://doi.org/10.1158/1535-7163.22505200
https://doi.org/10.1158/1535-7163.22505200
Autor:
Dennis R. Benjamin, Eric J. Feldman, Che-Leung Law, Peter D. Senter, Sa A. Wang, Maitrayee Goswami, Timothy S. Lewis, Mechthild Jonas, Weiping Zeng, Ivan J. Stone, Martha E. Anderson, Michelle Ulrich, Kerry Klussman, Django Sussman, Ashley Cronkite, Lucy Pan, John Valliere-Douglass, Lori Westendorf, Roland B. Walter, Changpu Yu, May Kung Sutherland, Fu Li
Treatment choices for acute myelogenous leukemia (AML) patients resistant to conventional chemotherapies are limited and novel therapeutic agents are needed. IL3 receptor alpha (IL3Rα, or CD123) is expressed on the majority of AML blasts, and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac8020bf88554cef4d7229c4d038ea4f
https://doi.org/10.1158/1535-7163.c.6537988.v1
https://doi.org/10.1158/1535-7163.c.6537988.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Julie A. McEarchern, Shang-Fan Yu, Jeffrey T. Lau, Kim Emmerton, Renee S. McCormick, Timothy S. Lewis
Purpose: Individually targeting B-cell antigens with monoclonal antibody therapeutics has improved the treatment of non-Hodgkin lymphoma (NHL). We examined if the antitumor activity of rituximab, CD20-specific antibody, could be improved by simultane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae208fc48358573fb7580321035ac60
https://doi.org/10.1158/1078-0432.c.6519305.v1
https://doi.org/10.1158/1078-0432.c.6519305.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplemental data Figure 2 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b0f02df417d29d3cdfdf216f7260c6
https://doi.org/10.1158/1078-0432.22439359.v1
https://doi.org/10.1158/1078-0432.22439359.v1
Autor:
Hans-Peter Gerber, Che-Leung Law, Iqbal S. Grewal, Elizabeth A. Repasky, Christopher G. Wood, Kristine Gordon, Ivan J. Stone, Ezogelin Oflazoglu
Purpose: The antitubulin agent monomethyl auristatin F (MMAF) induces potent antitumor effects when conjugated via protease cleavable linkers to antibodies targeting internalizing, tumor-specific cell surface antigens. Humanized 1F6 (h1F6) is a human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df88c305b3365a718896dca1e93ca52
https://doi.org/10.1158/1078-0432.c.6516921
https://doi.org/10.1158/1078-0432.c.6516921
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplementary Table 1. CD70 and CD27 expression on hematologic tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ad6c281bb23a2464a5e1982dbaa5f
https://doi.org/10.1158/1078-0432.22439347.v1
https://doi.org/10.1158/1078-0432.22439347.v1
Autor:
Holger Wesche, Che-Leung Law, Patrick A. Baeuerle, Timothy Z. Yu, Laurie Tatalick, Kenneth Sexton, Purbasa Patnaik, Kathryn L. Strobel, Susan D. Jones, Adrie Jones, Vaishnavi Ganti, Wade H. Aaron, Bryan D. Lemon, Richard J. Austin, Mary Ellen Molloy
Purpose:Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and triple-negative breast cancer. Early signs of clinical efficacy with MSLN-targeting age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb32ac1e74423fb577ba10f3003d4017
https://doi.org/10.1158/1078-0432.c.6530192.v1
https://doi.org/10.1158/1078-0432.c.6530192.v1
Autor:
Hans-Peter Gerber, Che-Leung Law, Iqbal S. Grewal, Elizabeth A. Repasky, Christopher G. Wood, Kristine Gordon, Ivan J. Stone, Ezogelin Oflazoglu
Supplementary Table S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac053db949d6c25e717f659f71c9e899
https://doi.org/10.1158/1078-0432.22439460
https://doi.org/10.1158/1078-0432.22439460