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Publikováno v:
Organic & Biomolecular Chemistry. 18:5370-5387
Hyaluronic acid (HA) is a ubiquitous glycosaminoglycan in the extracellular matrix and a ligand of CD44, a transmembrane glycoprotein that is important in cell migration. Crystal and NMR studies found a hexasaccharide of the pattern (GlcA-GlcNAc)3 as
Autor:
Chiao Chu Ku, Wei-Chen Lin, Che Jui Yeh, Yaw-Kuen Li, Shang-Cheng Hung, Yoshiyuki Manabe, Koichi Fukase, Chiao Yuan Fan, Medel Manuel L. Zulueta
Publikováno v:
Chembiochem : a European journal of chemical biology. 20(2)
Many circulating cancer-related proteins, such as fibroblast growth factors (FGFs), associate with glycosaminoglycans-particularly heparan sulfate-at the cell surface. Disaccharide analogues of heparan sulfate had previously been identified as the sh