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Synthesis of hyaluronic acid oligosaccharides with a GlcNAc–GlcA repeating pattern and their binding affinity with CD44

Autor: Shang-Cheng Hung, Che-Jui Yeh, Medel Manuel L. Zulueta, Yaw-Kuen Li

Publikováno v: Organic & Biomolecular Chemistry. 18:5370-5387

Hyaluronic acid (HA) is a ubiquitous glycosaminoglycan in the extracellular matrix and a ligand of CD44, a transmembrane glycoprotein that is important in cell migration. Crystal and NMR studies found a hexasaccharide of the pattern (GlcA-GlcNAc)3 as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eeca51bd331c5478e77d4655758fe6
https://doi.org/10.1039/d0ob01048k

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Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors

Autor: Chiao Chu Ku, Wei-Chen Lin, Che Jui Yeh, Yaw-Kuen Li, Shang-Cheng Hung, Yoshiyuki Manabe, Koichi Fukase, Chiao Yuan Fan, Medel Manuel L. Zulueta

Publikováno v: Chembiochem : a European journal of chemical biology. 20(2)

Many circulating cancer-related proteins, such as fibroblast growth factors (FGFs), associate with glycosaminoglycans-particularly heparan sulfate-at the cell surface. Disaccharide analogues of heparan sulfate had previously been identified as the sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36426bb12e7d6e2add8088d5ed6b2cb
https://pubmed.ncbi.nlm.nih.gov/30239102

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