Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Che Chang Chan"'
Autor:
Yun-Cheng Hsieh, Kuei-Chuan Lee, Hao-Jan Lei, Keng-Hsin Lan, Teh-Ia Huo, Yi-Tsung Lin, Che-Chang Chan, Bernd Schnabl, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 813-838 (2021)
Background & Aims: Activation of the (pro)renin receptor (PRR) up-regulates the expression of profibrotic genes in the kidney and heart. We aimed to investigate the role of PRR in hepatic fibrogenesis. Methods: Human hepatic PRR levels were measured
Externí odkaz:
https://doaj.org/article/70eb2e8ab0854e2ea7e30e6e10d78a1a
Autor:
Kuei-Chuan Lee, Che-Chang Chan, Ying-Ying Yang, Yun-Cheng Hsieh, Yi-Hsiang Huang, Han-Chieh Lin
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77817 (2013)
BACKGROUND & AIMS:Activation of the renin-angiotensin-system is known to play a role in nonalcoholic steatohepatitis. Renin knockout mice manifest decreased hepatic steatosis. Aliskiren is the first direct renin inhibitor to be approved for clinical
Externí odkaz:
https://doaj.org/article/9cdb5d76a918456e940cb5bf46eb7b62
Autor:
I-Cheng Lee, Chen-Hao Lin, Yi-Hsiang Huang, Teh-Ia Huo, Chien-Wei Su, Ming-Chih Hou, Hui-Chun Huang, Kuei-Chuan Lee, Che-Chang Chan, Ming-Wei Lin, Han-Chieh Lin, Shou-Dong Lee
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e58071 (2013)
BACKGROUND AIMS:The clinical relevance of single nucleotide polymorphisms (SNPs) near the IL28B gene is controversial in patients with hepatitis B virus (HBV) infection. This study aimed to investigate the role of viral and host factors, including IL
Externí odkaz:
https://doaj.org/article/19c76c20a6b2418eb3dd201e588582cb
Autor:
Che-Chang Chan, Ling-Yi Cheng, Jean Lu, Yi-Hsiang Huang, Shih-Hwa Chiou, Ping-Hsing Tsai, Teh-Ia Huo, Han-Chieh Lin, Fa-Yauh Lee
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50577 (2012)
BACKGROUND: Liver injuries are important medical problems that require effective therapy. Stem cell or hepatocyte transplantation has the potential to restore function of the damaged liver and ameliorate injury. However, the regulatory factors crucia
Externí odkaz:
https://doaj.org/article/8ab4654c4329466a81570cf136d927b8
Autor:
Han-Chieh Lin, Che Chang Chan, Yi Hsiang Huang, Yun Cheng Hsieh, Hao Jhe Sun, Kuei Chuan Lee, Ming Chih Hou
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 99(8)
Human relaxin-2 reduces hepatic fibrosis in mice. However, the effects of relaxin-2 on hepatic steatosis and fibrosis in animals with non-alcoholic fatty liver disease (NAFLD) remain to be elucidated. C57BL/6 mice fed a high-fat diet (HFD) or methion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e746129197bc04b0c77567a9086d8fc
https://pubmed.ncbi.nlm.nih.gov/30918325
https://pubmed.ncbi.nlm.nih.gov/30918325
Autor:
Che Chang Chan, Yun Cheng Hsieh, Han-Chieh Lin, Kuei Chuan Lee, Yi Hsiang Huang, Ming Chih Hou, Wei-Fan Hsu, Ying Ying Yang
Publikováno v:
Digestive diseases and sciences. 64(1)
Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd678764cc50ce9275fd661121826c08
https://pubmed.ncbi.nlm.nih.gov/30288660
https://pubmed.ncbi.nlm.nih.gov/30288660
Autor:
Yun Cheng Hsieh, Kuei Chuan Lee, Yi Chen Yeh, Ying Ying Yang, Shie-Liang Hsieh, Ying Wen Wang, Pei Chang Lee, Che Chang Chan, Tzung Yan Lee, Yi Hsiang Huang, Han-Chieh Lin
Publikováno v:
Journal of Hepatology. 61:1004-1013
Background & Aims Intestinal hyperpermeability, impaired peritoneal macrophages (PMs) phagocytosis, and bacterial translocation (BT), resulting in increased systemic and local infection/inflammation such as spontaneous bacterial peritonitis (SBP) tog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cc7098098ca1d716511165fd601168
https://doi.org/10.1016/j.jhep.2014.05.049
https://doi.org/10.1016/j.jhep.2014.05.049
Publikováno v:
Journal of Gastroenterology and Hepatology. 29:603-613
Background and Aim Acute liver injury is manifested by different degree of hepatocyte necrosis and may recover via the process of hepatocyte regeneration once the injury is discontinued. Most of the liver injury is associating with inflammatory cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcbdc759d0275bbff0fe5ee6dd24aa33
https://doi.org/10.1111/jgh.12366
https://doi.org/10.1111/jgh.12366
Autor:
Kuei Chuan Lee, Yi Hsiang Huang, Yun Cheng Hsieh, Ying Ying Yang, Han-Chieh Lin, Che Chang Chan
Publikováno v:
Scientific Reports
Aliskiren has been found to reduce chronic injury and steatosis in the liver of methionine-choline-deficient (MCD) diet-fed mice. This study investigated whether aliskiren has an anti-steatotic effect in HFD-fed mice, which are more relevant to human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c9cb904734ea271256b8a8eddd5fad
http://europepmc.org/articles/PMC4702081
http://europepmc.org/articles/PMC4702081
Autor:
Yi-Chen Yeh, Kuei-Chuan Lee, Ying-Ying Yang, Che-Chang Chan, Han-Chieh Lin, Yi-Tsau Huang, Tzung-Yan Lee
Publikováno v:
Liver Transplantation. 18:1371-1383
During liver transplantation, nonalcoholic steatohepatitis (NASH) aggravates ischemia/reperfusion (IR) injury by activating various kinases and subsequently releasing cytokines and chemokines. Nonetheless, the effect of the multikinase inhibitor sora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf059517c31087eed81515a086e6be6
https://doi.org/10.1002/lt.23520
https://doi.org/10.1002/lt.23520