A cell-based high-throughput screen for novel chemical inducers of fetal hemoglobin for treatment of hemoglobinopathies.

Autor: Peterson KR; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America; Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Costa FC; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Fedosyuk H; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Neades RY; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Chazelle AM; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Zelenchuk L; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Fonteles AH; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Dalal P; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Roy A; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, United States of America., Chaguturu R; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, United States of America., Li B; Department of Pediatrics, Georgia Regents University, Augusta, Georgia, United States of America., Pace BS; Department of Pediatrics, Georgia Regents University, Augusta, Georgia, United States of America; Department of Molecular and Cell Biology, Georgia Regents University, Augusta, Georgia, United States of America.

Publikováno v: PloS one [PLoS One] 2014 Sep 16; Vol. 9 (9), pp. e107006. Date of Electronic Publication: 2014 Sep 16 (Print Publication: 2014).