Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chayki Charar"'
Autor:
Sahar Elouej, Karim Harhouri, Morgane Le Mao, Genevieve Baujat, Sheela Nampoothiri, Hϋlya Kayserili, Nihal Al Menabawy, Laila Selim, Arianne Llamos Paneque, Christian Kubisch, Davor Lessel, Robert Rubinsztajn, Chayki Charar, Catherine Bartoli, Coraline Airault, Jean-François Deleuze, Agnes Rötig, Peter Bauer, Catarina Pereira, Abigail Loh, Nathalie Escande-Beillard, Antoine Muchir, Lisa Martino, Yosef Gruenbaum, Song-Hua Lee, Philippe Manivet, Guy Lenaers, Bruno Reversade, Nicolas Lévy, Annachiara De Sandre-Giovannoli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Mandibuloacral dysplasias (MADs) are rare progeroid syndromes characterized by nuclear morphological and functional abnormalities. Here the authors report that loss of mitochondrial membrane protein MTX2 causes a progeroid MAD sharing clinical featur
Externí odkaz:
https://doaj.org/article/21379d0d1eab48b298abdd7e9cc58e7d
Autor:
Sahar Elouej, Karim Harhouri, Morgane Le Mao, Genevieve Baujat, Sheela Nampoothiri, Hϋlya Kayserili, Nihal Al Menabawy, Laila Selim, Arianne Llamos Paneque, Christian Kubisch, Davor Lessel, Robert Rubinsztajn, Chayki Charar, Catherine Bartoli, Coraline Airault, Jean-François Deleuze, Agnes Rötig, Peter Bauer, Catarina Pereira, Abigail Loh, Nathalie Escande-Beillard, Antoine Muchir, Lisa Martino, Yosef Gruenbaum, Song-Hua Lee, Philippe Manivet, Guy Lenaers, Bruno Reversade, Nicolas Lévy, Annachiara De Sandre-Giovannoli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/153909fa41324897863611c6fc386797
Autor:
Kfir Sharabi, Chayki Charar, Nurit Friedman, Inbar Mizrahi, Alon Zaslaver, Jacob I Sznajder, Yosef Gruenbaum
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004529 (2014)
Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contract
Externí odkaz:
https://doaj.org/article/6e0bcdfb7fa54852a48f733d6fb3690a
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Animals subjected to dietary restriction (DR) have reduced body size, low fecundity, slower development, lower fat content and longer life span. We identified lamin as a regulator of multiple dietary restriction phenotypes. Downregulation of lmn-1, t
Publikováno v:
Current topics in developmental biology. 144
The eukaryotic genome inside the nucleus is enveloped by two membranes, the Outer Nuclear Membrane (ONM) and the Inner Nuclear Membrane (INM). Tethered to the INM is the nuclear lamina, a fibrillar network composed of lamins-the nuclear intermediate
Publikováno v:
Current Topics in Developmental Biology ISBN: 9780128161777
The eukaryotic genome inside the nucleus is enveloped by two membranes, the Outer Nuclear Membrane (ONM) and the Inner Nuclear Membrane (INM). Tethered to the INM is the nuclear lamina, a fibrillar network composed of lamins-the nuclear intermediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaab25bea35633056bd8e3ed5ce6a2f6
https://doi.org/10.1016/bs.ctdb.2020.12.005
https://doi.org/10.1016/bs.ctdb.2020.12.005
Autor:
Christian Kubisch, Robert Rubinsztajn, Arianne Llamos Paneque, Philippe Manivet, Catarina Pereira, Laila Selim, Nathalie Escande-Beillard, Abigail Loh, Peter Bauer, Catherine Bartoli, Song-Hua Lee, Morgane Le Mao, Hϋlya Kayserili, Coraline Airault, Nihal M. Al Menabawy, Lisa Martino, Yosef Gruenbaum, Guy Lenaers, Antoine Muchir, Agnès Rötig, Annachiara De Sandre-Giovannoli, Nicolas Lévy, Sahar Elouej, Sheela Nampoothiri, Chayki Charar, Jean-François Deleuze, Karim Harhouri, Bruno Reversade, Davor Lessel, Geneviève Baujat
Publikováno v:
Nature communications, 11(1):4589. Nature Publishing Group
Nature Communications
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-18146-9⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-18146-9⟩
Nature Communications
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-18146-9⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-18146-9⟩
Mandibuloacral dysplasia syndromes are mainly due to recessive LMNA or ZMPSTE24 mutations, with cardinal nuclear morphological abnormalities and dysfunction. We report five homozygous null mutations in MTX2, encoding Metaxin-2 (MTX2), an outer mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06373a33d6f632cebef13745fddc34b8
https://pure.amc.nl/en/publications/loss-of-mtx2-causes-mandibuloacral-dysplasia-and-links-mitochondrial-dysfunction-to-altered-nuclear-morphology(60508de2-5a6c-49eb-9d5b-9742fc986ced).html
https://pure.amc.nl/en/publications/loss-of-mtx2-causes-mandibuloacral-dysplasia-and-links-mitochondrial-dysfunction-to-altered-nuclear-morphology(60508de2-5a6c-49eb-9d5b-9742fc986ced).html
Animals subjected to dietary restriction (DR) have reduced body size, low fecundity, slower development, lower fat content and longer life span. We identified lamin as a regulator of multiple dietary restriction phenotypes. Downregulation oflmn-1, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba3df5600b3f0faea6cd4b83afdfd52
https://doi.org/10.1101/2020.10.27.357913
https://doi.org/10.1101/2020.10.27.357913
Autor:
Noam Zuela-Sopilniak, Amnon Buxboim, Yosef Gruenbaum, Oren Wintner, Chayki Charar, Daniel Bar-Sela
Publikováno v:
Molecular Biology of the Cell
Nuclei within cells are constantly subjected to compressive, tensile and shear forces, which regulate nucleoskeletal and cytoskeletal remodeling, activate signaling pathways and direct cell-fate decisions. Multiple rheological methods have been adapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcd5bca4c8b8d3d42c2da5f5a425655
https://doi.org/10.1101/2020.02.05.935395
https://doi.org/10.1101/2020.02.05.935395
Autor:
Chayki Charar, Yosef Gruenbaum
Publikováno v:
Clinical Science. 131:105-111
Lamins are nuclear intermediate filaments (IFs) with important roles in most nuclear activities, including nuclear organization and cell-cycle progression. Mutations in human lamins cause over 17 different diseases, termed laminopathies. Most of thes