Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Chayan, Acharya"'
Publikováno v:
The Journal of Clinical Pharmacology. 63:435-444
Systemic lupus erythematosus (SLE) is a systemic, autoimmune disease characterized by chronic inflammation and organ damage. Dapirolizumab pegol inhibits CD40 ligand (CD40L) and is currently undergoing phase 3 trials for the treatment of SLE. To desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c37d05bab569412d18975ee0a4982ea
https://doi.org/10.1002/jcph.2188
https://doi.org/10.1002/jcph.2188
Autor:
Chayan Acharya
Publikováno v:
Development in E-waste Management ISBN: 9781003301899
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0ffe9952584980244b30f3b17a57ea1
https://doi.org/10.1201/9781003301899-10
https://doi.org/10.1201/9781003301899-10
Autor:
Brad C. Bennett, Michael D. Purdy, Kent A. Baker, Chayan Acharya, William E. McIntire, Raymond C. Stevens, Qinghai Zhang, Andrew L. Harris, Ruben Abagyan, Mark Yeager
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to pr
Externí odkaz:
https://doaj.org/article/8711c8402a1e467da4c3721f1fe65a53
Autor:
Aaron Petty, Eugene Myshkin, Haina Qin, Hong Guo, Hui Miao, Gregory P Tochtrop, Jer-Tsong Hsieh, Phillip Page, Lili Liu, Daniel J Lindner, Chayan Acharya, Alexander D MacKerell, Eckhard Ficker, Jianxing Song, Bingcheng Wang
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42120 (2012)
During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressi
Externí odkaz:
https://doaj.org/article/d179e54248b847f4955532d762afd815
Autor:
Suresh Kankanwadi, Chayan Acharya, Andrew C. Hooker, Gunnar Yngman, Elodie L. Plan, Luis Lopez-Lazaro, Ari Brekkan, Mats O. Karlsson
Neutropenia and febrile neutropenia (FN) are serious side effects of cytotoxic chemotherapy which may be alleviated with the administration of recombinant granulocyte colony-stimulating factor (GCSF) derivatives, such as pegfilgrastim (PG) which incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2c17ab578916a46c2d03e67524a351
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362482
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362482
Publikováno v:
Biochemical and biophysical research communications, vol 445, iss 4
We developed PeptiSite, a comprehensive and reliable database of biologically and structurally characterized peptide-binding sites, in which each site is represented by an ensemble of its complexes with protein, peptide and small molecule partners. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2726d521cf3e418785e05008e05bc21f
https://doi.org/10.1016/j.bbrc.2013.12.132
https://doi.org/10.1016/j.bbrc.2013.12.132
WOS: 000372521500008
PubMed ID: 27000291
Background and objective: Non-compartmental analysis (NCA) calculates pharmacokinetic (PK) metrics related to the systemic exposure to a drug following administration, e.g. area under the concentrati
PubMed ID: 27000291
Background and objective: Non-compartmental analysis (NCA) calculates pharmacokinetic (PK) metrics related to the systemic exposure to a drug following administration, e.g. area under the concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40bf29a70714bda891c4b661afe4a4e
https://aperta.ulakbim.gov.tr/record/54201
https://aperta.ulakbim.gov.tr/record/54201
Publikováno v:
Current Computer Aided-Drug Design. 7:10-22
In the absence of three-dimensional (3D) structures of potential drug targets, ligand-based drug design is one of the popular approaches for drug discovery and lead optimization. 3D structure-activity relationships (3D QSAR) and pharmacophore modelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e969e057d725860e7d1cc7fdb2d2b31
https://doi.org/10.2174/157340911793743547
https://doi.org/10.2174/157340911793743547
Autor:
Andrew Coop, Angela Wilks, Alexander D. MacKerell, Kellie Hom, Chayan Acharya, Christopher W. Cunningham
Publikováno v:
Helvetica Chimica Acta. 93:220-226
The Diels – Alder reaction was applied to 4,5-epoxymorphinan opioids to generate a novel aromatic cycloadduct at C(7) – C(8): Thermolytic cleavage of sultine 8 produced the reactive diene o-quinodimethane 7 which condensed favorably with codeine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d6f91bc5dcc34ecf562f923ef5a09c
https://doi.org/10.1002/hlca.200900234
https://doi.org/10.1002/hlca.200900234
Publikováno v:
Pharmaceutical Research. 26:1665-1678
Synthesize aminopiperidine conjugates of glutamyl-bile acids (glu-BAs) and develop a hASBT inhibition model using the conformationally sampled pharmacophore (CSP) approach. glu-BAs aminopiperidine conjugates were synthesized. hASBT inhibition was mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3659ee6b08af81e4be881a5ddfa1eee
https://doi.org/10.1007/s11095-009-9877-3
https://doi.org/10.1007/s11095-009-9877-3