Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chauncey J. Spooner"'
Autor:
Chrystal M. Paulos, Laura L. Carter, Weiping Zou, Jacques Moisan, Chauncey J. Spooner, Megan M. Wyatt, Xikui Liu, Kinga Majchrzak, Xiao Hu
Adoptive T-cell transfer therapy is an FDA- approved treatment for leukemia that relies on the ex vivo expansion and reinfusion of a patient's immune cells, which can be engineered with a chimeric antigen receptor (CAR) for more efficient tumor recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d038dd577344f768f7d9f83e5b76b18
https://doi.org/10.1158/0008-5472.c.6510324
https://doi.org/10.1158/0008-5472.c.6510324
Autor:
Chrystal M. Paulos, Laura L. Carter, Weiping Zou, Jacques Moisan, Chauncey J. Spooner, Megan M. Wyatt, Xikui Liu, Kinga Majchrzak, Xiao Hu
Supplementary Figure S1 shows that RORgamma agonist treatment does not impact the transduction efficiency of CAR virus. Supplementary Figure S2 shows that RORgamma agonist treatment increases IL-17A secretion from TRP-1 Th0 and Th17 cells. Included i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffe92c02a8d456b0978f75547f1dfc0
https://doi.org/10.1158/0008-5472.22419243.v1
https://doi.org/10.1158/0008-5472.22419243.v1
Autor:
Xikui Liu, Jacques Moisan, Xiao Hu, Megan M. Wyatt, Chrystal M. Paulos, Kinga Majchrzak, Laura L. Carter, Weiping Zou, Chauncey J. Spooner
Adoptive T-cell transfer therapy is an FDA- approved treatment for leukemia that relies on the ex vivo expansion and reinfusion of a patient's immune cells, which can be engineered with a chimeric antigen receptor (CAR) for more efficient tumor recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199a8774f6aa8c14ff2c944eaf655172
https://europepmc.org/articles/PMC6238208/
https://europepmc.org/articles/PMC6238208/
Autor:
Justin Lesch, Min Xu, Ira Mellman, Lélia Delamarre, Aly A. Khan, Meijuan Zhou, Wyne P. Lee, Chauncey J. Spooner, Smita Agrawal, Bryan Vander Lugt, Jason DeVoss, Harinder Singh, Jason A. Hackney, Cecile Chalouni, Summer Park
Publikováno v:
Nature Immunology. 15:161-167
CD11b(+) dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory basis for this is not established. Conditional deletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fb658f981c484d9d7ed88770415a91
https://doi.org/10.1038/ni.2795
https://doi.org/10.1038/ni.2795
Autor:
Smita Agrawal, Jason A. Hackney, Aly A. Khan, Maria Ciofani, Wenjun Ouyang, Chauncey J. Spooner, Elke Glasmacher, Roza Nurieva, Bryan Vander Lugt, Wenwen Zeng, Dan R. Littman, Carlos R. Escalante, Theresa L. Murphy, Kenneth M. Murphy, Abraham B Chang, Sascha Rutz, Harinder Singh
Publikováno v:
Science. 338:975-980
Helping T Helper Transcription Members of the interferon response family of transcription factors (IRFs) are specifically expressed in immune cells and are known to regulate their differentiation. IRF4 and IRF8 regulate gene expression by binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a197f94b442cbaffd444ac1af8c7b4ea
https://doi.org/10.1126/science.1228309
https://doi.org/10.1126/science.1228309
Autor:
Rebecca Mathew, Michael P. Seiler, Albert Bendelac, Fanyong Meng, Kenneth Barr, Chauncey J. Spooner, Harinder Singh, Megan K Liszewski
Publikováno v:
Nature immunology
Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c204a4c1512df76293cb9908d9226d
https://doi.org/10.1038/ni.2230
https://doi.org/10.1038/ni.2230
Autor:
Jason DeVoss, Jeffrey Eastham-Anderson, Donghong Yan, Justin Lesch, Aly A. Khan, Harinder Singh, Lauri Diehl, Vladimir Ramirez-Carrozzi, Robert Soriano, Meijuan Zhou, Wyne P. Lee, Rajita Pappu, Chauncey J. Spooner, Zora Modrusan, Min Xu, Alexander R. Abbas
Publikováno v:
Nature immunology. 14(12)
Type 2 innate lymphoid cells (ILC2 cells) participate in host defense against helminth parasites and in allergic inflammation. Given their functional relatedness to type 2 helper T cells (T(H)2 cells), we explored whether Gfi1 acts as a shared transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00a1578402926d4e0ca1920f7eee24b
https://pubmed.ncbi.nlm.nih.gov/24141388
https://pubmed.ncbi.nlm.nih.gov/24141388
Autor:
Weiping Zou, Don Skalitzky, Thomas Daniel Aicher, Charles A Lesch, Laura L. Carter, Kinga Majchrzak, Rodney W. Morgan, Peter L. Toogood, Chrystal M. Paulos, David Mertz, Ilona Kryczek, Yahong Wang, Chad A. Van Huis, Gary D. Glick, Xiao Hu, Chauncey J. Spooner, Xikui Liu, Jacques Moisan, Dick Bousley, Clarke Taylor, Elizabeth Zawidzka, Alexander R. Hurd
Publikováno v:
Oncoimmunology
RORγt is the key transcription factor controlling the development and function of CD4+ Th17 and CD8+ Tc17 cells. Across a range of human tumors, about 15% of the CD4+ T cell fraction in tumor-infiltrating lymphocytes are RORγ+ cells. To evaluate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d637395d3adb5a2aa4dff7e14b02647c
https://doi.org/10.1080/2162402x.2016.1254854
https://doi.org/10.1080/2162402x.2016.1254854
Autor:
Hilde Schjerven, Chauncey J. Spooner, Damien Reynaud, Karen L. Reddy, Harinder Singh, Stephen T. Smale, Eric Bertolino, Susan Winandy
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1775ac8c494d19918b20fd8d8fc2be5
https://doi.org/10.1096/fasebj.22.1_supplement.844.7
https://doi.org/10.1096/fasebj.22.1_supplement.844.7
Autor:
Richard C. Schwartz, Srinivasan Durairaj, Thomas Sebastian, Chauncey J. Spooner, Peter F. Johnson, Xiangrong Guo, Jon Shuman
Publikováno v:
Cytokine. 37(2)
C/EBPbeta is a member of the CCAAT/enhancer binding protein family of transcription factors and has been shown to be a critical transcriptional regulator of various proinflammatory genes, including IL-6 and MCP-1. Serine 64 in the transactivation dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba0cd94ff5de51e24204bed75f6c780
https://pubmed.ncbi.nlm.nih.gov/17433708
https://pubmed.ncbi.nlm.nih.gov/17433708