Liposomal Irinotecan Shows a Larger Therapeutic Index than Non-liposomal Irinotecan in Patient-Derived Xenograft Models of Pancreatic Cancer

Autor: Sandrine Barbier, Benjamin Beaufils, Ricardo de Miguel, Melissa Reyre, Yannick Le Meitour, Andreanne Lortie, Marc Hillairet de Boisferon, Sophie Chaumeron, Anne Espirito, Lina Fossati, Pauline Lagarde, Stephan Klinz, Arunthathi Thiagalingam, Stéphane Lezmi, Florence Meyer-Losic

Publikováno v: Oncology and Therapy, Vol 11, Iss 1, Pp 111-128 (2023)

Abstract Introduction Liposomal irinotecan promotes controlled sustained release of irinotecan (CPT-11), therefore, we hypothesize that the therapeutic index (quantitative measurement of the relative efficacy/safety ratio of a drug) will be higher fo

Externí odkaz: https://doaj.org/article/be2e3c3c269d460ab70f6f7799bd0e5d

Preoperative vaping prevalence and behavior of French surgical patients: A multicentre study

Autor: Yann Gricourt, Hamadi Ghezal, Pierre G. Claret, Lana Zoric, Arnaud Chaumeron, Mathieu Raux, Bastian Nucci, Emmanuel Lorne, Jean Y. Lefrant, Philippe Cuvillon

Publikováno v: Tobacco Induced Diseases, Vol 17, Iss November (2019)

Introduction Prevalence and tobacco-related perioperative complications have been largely reported. The impact of vaping (e-cigarette use) on the perioperative period has been rarely evaluated. The purpose of this multicentre cross-sectional survey w

Externí odkaz: https://doaj.org/article/b1a06a9fae49442db649e87e31b37ab7

LB992 NTX-2009, a novel charged sodium channel blocker has significant anti-inflammatory activity in an atopic dermatitis model and produces sustained inhibition of chloroquine-induced itch

Autor: J. Ellis, S. Chaumeron, K. LaVigne, M. Lipp, A. Malekiani, B.M. Cole

Publikováno v: Journal of Investigative Dermatology. 142:B27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61320178321f26b3a803bbfb6f26fa40
https://doi.org/10.1016/j.jid.2022.05.1016

Efficacy and safety of remifentanil in a rapid sequence induction in elderly patients: A three-arm parallel, double blind, randomised controlled trial

Autor: Jean-Yves Lefrant, Arnaud Chaumeron, Patrick Basset, L.-P. Fortier, Jeremie Castanie, Sandrine Alonso, Sophie Bastide, Philippe Cuvillon

Publikováno v: Anaesthesia Critical Care & Pain Medicine
Anaesthesia Critical Care & Pain Medicine, Elsevier Masson, 2020, 39 (2), pp.215-220. ⟨10.1016/j.accpm.2019.09.010⟩

International audience; Background: Rapid sequence induction (RSI) is recommended in patients at risk of aspiration, but induced haemodynamic adverse events, including tachycardia. In elderly patients, this trial aimed to assess the impact of the add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b05db4a94d8e947cbf89fdc3b758233
https://hal.umontpellier.fr/hal-02775891

Role of the internet as an information resource before anaesthesia consultation

Autor: Philippe Grillo, Arnaud Chaumeron, Pierre-Géraud Claret, Gilles Leclerc, Clément Buléon, Vincent Leprince, Mathieu Raux, Emmanuel Futier, Bastian Nucci, Philippe Cuvillon, Vincent Minville, Jean-Yves Lefrant

Publikováno v: European Journal of Anaesthesiology. 34:831-835

BACKGROUND Use of the internet as an information search tool has increased dramatically. Our study assessed preoperative use of the internet by patients to search for information regarding anaesthesia, surgery, pain or outcomes. OBJECTIVE(S) The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a017f8dabb6f4b4552b7535889e55bd6
https://doi.org/10.1097/eja.0000000000000686