Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chau-Dung Chang"'
Autor:
Zhijun Wang, Erik Boman, Jan Urban, Jeff Kucharski, Hiroshi Nakanishi, Jan Lundström, Nancy G. J. Delaet, Justin T. Ernst, Eddine Saiah, Christopher Lum, Eric Erb, Antonio Garrido Montalban, Susana Conde Ceide, Russell Dahl, Linda Kessler, Stephen E. Miller, Christopher J. Larson, Chau-Dung Chang, Edward Roberts, Jeffrey Kahl, Robert K. P. Sullivan, Andrew Gibbs, David Dalesandro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4819-4824
We have optimized a novel series of potent p38 MAP kinase inhibitors based on an alpha-ketoamide scaffold through structure based design that due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646db32d2692e24d80d296daacfeccd7
https://doi.org/10.1016/j.bmcl.2010.06.102
https://doi.org/10.1016/j.bmcl.2010.06.102
Autor:
Jan Lundström, Eric Erb, Susana Conde Ceide, Eddine Saiah, Jeff Kahl, Stephen E. Miller, Andrew Gibbs, Edward Roberts, Nancy G. J. Delaet, Antonio Garrido Montalban, Robert K. P. Sullivan, Erik Boman, Zhijun Wang, Christopher J. Larson, David Dalesandro, Russell Dahl, Chau-Dung Chang, Hiroshi Nakanishi, Linda Kessler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5456-5459
We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8879f4a8eb58917957fc3b2d5d8d5e
https://doi.org/10.1016/j.bmcl.2008.09.028
https://doi.org/10.1016/j.bmcl.2008.09.028
Publikováno v:
Journal of Chromatography A. 1194:172-177
Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) is widely used as important colorant in the aquaculture feed industry, and as nutraceuticals in human health products. Synthetic all-trans-astaxanthin consists of a mixture of a pair of enant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c37166c916294c67eb3f6b50db7b66e
https://doi.org/10.1016/j.chroma.2008.04.063
https://doi.org/10.1016/j.chroma.2008.04.063
Autor:
Eric Erb, Russell Dahl, Jan Lundström, Robert K. P. Sullivan, Chau-Dung Chang, Erik Boman, Edward Roberts, Antonio Garrido Montalban, Andrew Gibbs, Justin T. Ernst, Jeffrey Kahl, Hiroshi Nakanishi, Nancy G. J. Delaet, Eddine Saiah, Linda Kessler, Stephen E. Miller, Susana Conde Ceide, Christopher J. Larson, David Dalesandro, Zhijun Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1772-1777
We have identified a novel series of potent p38 MAP kinase inhibitors through structure-based design which due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADME and in vivo PK studies s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1a60a704c68cbb7566ac6bd4230098
https://doi.org/10.1016/j.bmcl.2008.02.033
https://doi.org/10.1016/j.bmcl.2008.02.033
Publikováno v:
Journal of Liquid Chromatography. 17:19-32
Metolachlor (2-chloro-N-(2′-ethyl-6′-methylphenyl)-N-(2-methoxy-l-methylethyl)acetamide) is one of the most widely used and important herbicides throughout the world. In order to understand the biodegradation pathways for this compound it is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607b929e4948835da5690ba44e0d1b7d
https://doi.org/10.1080/10826079408013433
https://doi.org/10.1080/10826079408013433
Publikováno v:
Talanta. 40:1367-1373
Cyclodextrins (CDs) can be bound on silica to prepare chiral stationary phases (CSPs) for liquid chromatography. The cyclodextrin ring is connected to a spacer previously bonded on the silica surface. Three different CD-CSPs were prepared with three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb91eeb2b2036585f9df4dc4daebba
https://doi.org/10.1016/0039-9140(93)80212-a
https://doi.org/10.1016/0039-9140(93)80212-a
Publikováno v:
Journal of Liquid Chromatography. 15:545-556
Although beta-adrenergic blocking agents are a relatively new group of drugs, they have proven to be very useful in medical pharmacology. Since the successful introduction of propranolol (Inderal) a variety of analogous compounds have been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf07d8df05d13fb1efb47f0e4e8f92c
https://doi.org/10.1080/10826079208017191
https://doi.org/10.1080/10826079208017191
Autor:
David Dalesandro, Eddine Saiah, Antonio Garrido Montalban, Justin T. Ernst, Stephen E. Miller, Christopher J. Larson, Hiroshi Nakanishi, Russell Dahl, Eric Erb, Edward Roberts, Zhijun Wang, Susana Conde Ceide, Linda Kessler, Jeffrey Kahl, Andrew Gibbs, Erik Boman, Robert K. P. Sullivan, Nancy G. J. Delaet, Chau-Dung Chang, Jan Lundström
Publikováno v:
European journal of pharmacology. 632(1-3)
The tumor necrosis factor-alpha (TNF-alpha) cytokine, secreted by activated monocytes/macrophages and T lymphocytes, is implicated in several diseases, including rheumatoid arthritis, chronic obstructive pulmonary disease, inflammatory bowel disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84966429599745c5e41120e6e036f2b6
https://pubmed.ncbi.nlm.nih.gov/20132813
https://pubmed.ncbi.nlm.nih.gov/20132813
Publikováno v:
Journal of Chromatography A. 539:83-90
(R)- and (S)-naphthylethylcarbamate-β-cyclodextrin bonded phases were originally developed for the normal-phase separation of enantiomers. Although their selectivity resembled that of some of the earlier substituted cellulosic phases, the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22df1c8e90e25c54895117b8df1e3389
https://doi.org/10.1016/s0021-9673(01)95362-2
https://doi.org/10.1016/s0021-9673(01)95362-2
Publikováno v:
Journal of Agricultural and Food Chemistry. 38:1674-1677
A series of new derivatized cyclodextrins have been developed for use as chiral stationary phases in capillary gas chromatography. As a result, a large number of the enantiomeric components in food and beverage products can be resolved relatively qui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6634e383f53f10508109bcce57d8f141
https://doi.org/10.1021/jf00098a010
https://doi.org/10.1021/jf00098a010