Contact map dependence of a T cell receptor binding repertoire

Autor: Chau, Kevin Ng, George, Jason T., Onuchic, José N., Lin, Xingcheng, Levine, Herbert

The T cell arm of the adaptive immune system provides the host protection against unknown pathogens by discriminating between host and foreign material. This discriminatory capability is achieved by the creation of a repertoire of cells each carrying

Externí odkaz: http://arxiv.org/abs/2112.14879

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire.

Autor: Lin X; Center for Theoretical Biological Physics, Rice University, Houston, TX.; Department of Physics and Astronomy, Rice University, Houston, TX.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA., George JT; Center for Theoretical Biological Physics, Rice University, Houston, TX.; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX., Schafer NP; Center for Theoretical Biological Physics, Rice University, Houston, TX.; Departments of Chemistry, Rice University, Houston, TX., Chau KN; Department of Physics, Northeastern University, Boston, MA., Birnbaum ME; Koch Institute for Integrative Cancer Research, Cambridge, MA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.; Ragon Institute of MIT, MGH, and Harvard, Cambridge, MA., Clementi C; Center for Theoretical Biological Physics, Rice University, Houston, TX.; Departments of Chemistry, Rice University, Houston, TX.; Department of Physics, Freie Universität, Berlin, Germany., Onuchic JN; Center for Theoretical Biological Physics, Rice University, Houston, TX.; Department of Physics and Astronomy, Rice University, Houston, TX.; Departments of Chemistry, Rice University, Houston, TX.; Department of Biosciences, Rice University, Houston, TX., Levine H; Center for Theoretical Biological Physics, Rice University, Houston, TX.; Department of Physics, Northeastern University, Boston, MA.

Publikováno v: Nature computational science [Nat Comput Sci] 2021 May; Vol. 1 (5), pp. 362-373. Date of Electronic Publication: 2021 May 24.