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Marinopyrrole derivative MP1 as a novel anti-cancer agent in group 3 MYC-amplified Medulloblastoma.

Autor: Coulter DW; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Chhonker YS; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Kumar D; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Kesherwani V; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Aldhafiri WN; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA., McIntyre EM; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Alexander G; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Ray S; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Joshi SS; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Li R; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Murry DJ; Department of Pharmacy Practice & Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Chaturvedi NK; Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA. nchaturvedi@unmc.edu.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA. nchaturvedi@unmc.edu.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA. nchaturvedi@unmc.edu.; Department of Pediatrics, Hematology and Oncology Division, University of Nebraska Medical Center, Omaha, NE, 68198, USA. nchaturvedi@unmc.edu.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jan 11; Vol. 43 (1), pp. 18. Date of Electronic Publication: 2024 Jan 11.

STAT3 Inhibition Attenuates MYC Expression by Modulating Co-Activator Recruitment and Suppresses Medulloblastoma Tumor Growth by Augmenting Cisplatin Efficacy In Vivo.

Autor: Rohrer KA; Department of Pediatrics, Hematology and Oncology Division, Nebraska Medical Center, Omaha, NE 68198, USA., Song H; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Medicine, University of Arizona, Tucson, AZ 85721, USA., Akbar A; Department of Pediatrics, Hematology and Oncology Division, Nebraska Medical Center, Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA., Chen Y; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA., Pramanik S; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA., Wilder PJ; Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198, USA., McIntyre EM; Department of Pediatrics, Hematology and Oncology Division, Nebraska Medical Center, Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA., Chaturvedi NK; Department of Pediatrics, Hematology and Oncology Division, Nebraska Medical Center, Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Fred & Pamela Buffett Cancer Center, Omaha, NE 68198, USA., Bhakat KK; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Fred & Pamela Buffett Cancer Center, Omaha, NE 68198, USA., Rizzino A; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198, USA.; Fred & Pamela Buffett Cancer Center, Omaha, NE 68198, USA., Coulter DW; Department of Pediatrics, Hematology and Oncology Division, Nebraska Medical Center, Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Fred & Pamela Buffett Cancer Center, Omaha, NE 68198, USA., Ray S; Department of Pediatrics, Hematology and Oncology Division, Nebraska Medical Center, Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198, USA.

Publikováno v: Cancers [Cancers (Basel)] 2023 Apr 11; Vol. 15 (8). Date of Electronic Publication: 2023 Apr 11.

miR-15a and miR-15b modulate natural killer and CD8 ⁺ T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma.

Autor: Pathania AS; Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Prathipati P; Laboratory of Bioinformatics, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki City, Osaka 567-0085, Japan., Olwenyi OA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Chava S; Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Smith OV; Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Gupta SC; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India., Chaturvedi NK; Department of Pediatrics, Division of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA., Byrareddy SN; Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA., Coulter DW; Department of Pediatrics, Division of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA., Challagundla KB; Department of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.; The Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Publikováno v: Molecular therapy oncolytics [Mol Ther Oncolytics] 2022 Mar 31; Vol. 25, pp. 308-329. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).

Subgroup-Specific Diagnostic, Prognostic, and Predictive Markers Influencing Pediatric Medulloblastoma Treatment.

Autor: Ray S; Department of Pediatrics, University of Nebraska Medical Center, 601 S Saddle Creek Road, Omaha, NE 68198, USA.; Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68105, USA., Chaturvedi NK; Department of Pediatrics, University of Nebraska Medical Center, 601 S Saddle Creek Road, Omaha, NE 68198, USA.; Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68105, USA., Bhakat KK; Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68105, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA., Rizzino A; Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68105, USA.; Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha, NE 68198, USA., Mahapatra S; Department of Pediatrics, University of Nebraska Medical Center, 601 S Saddle Creek Road, Omaha, NE 68198, USA.; Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68105, USA.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Publikováno v: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2021 Dec 28; Vol. 12 (1). Date of Electronic Publication: 2021 Dec 28.