The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner

Autor: Lunsonga, Lynn C., Fatehi, Mohammad, Long, Wentong, Barr, Amy J., Gruber, Brittany, Chattopadhyay, Arkapravo, Barakat, Khaled, Edwards, Andrew G., Light, Peter E.

Publikováno v: In Journal of Molecular and Cellular Cardiology January 2025 198:99-111

The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner.

Autor: Lunsonga LC; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Fatehi M; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Long W; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Barr AJ; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Gruber B; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada., Chattopadhyay A; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton. 2-35 Medical Sciences Building, Edmonton T6G 2H1, Alberta, Canada., Barakat K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton. 2-35 Medical Sciences Building, Edmonton T6G 2H1, Alberta, Canada., Edwards AG; Department of Computational Physiology, Simula Research Laboratory, Kristian Augusts gate 23, Oslo 0164, Norway., Light PE; Department of Pharmacology, Alberta Diabetes Institute, Faculty of Medicine and Dentistry, University of Alberta, 7-55 Medical Sciences Building, Edmonton T6G 2H7, Alberta, Canada. Electronic address: plight@ualberta.ca.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Dec 02; Vol. 198, pp. 99-111. Date of Electronic Publication: 2024 Dec 02.