A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer.

Autor: Yochum ZA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Cades J; Department of Pharmacology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mazzacurati L; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Neumann NM; Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, Maryland., Khetarpal SK; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Chatterjee S; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Wang H; Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Attar MA; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Huang EH; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Chatley SN; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Nugent K; Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Somasundaram A; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Engh JA; Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Ewald AJ; Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cho YJ; Division of Pediatric Neurology, Oregon Health & Science University, Portland, Oregon., Rudin CM; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York., Tran PT; Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Burns TF; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania. burnstf@upmc.edu.; Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2017 Dec; Vol. 15 (12), pp. 1764-1776. Date of Electronic Publication: 2017 Aug 29.