Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Chathura J Gunasekara"'
Autor:
Wen-Jou Chang, Maria S. Baker, Eleonora Laritsky, Chathura J. Gunasekara, Uditha Maduranga, Justine C. Galliou, Joseph W. McFadden, Jessica R. Waltemyer, Bruce Berggren-Thomas, Brianna N. Tate, Hanxue Zhang, Benjamin D. Rosen, Curtis P. Van Tassell, George E. Liu, Cristian Coarfa, Yi Athena Ren, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background We recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These methylation variants are amenable to population studies, as DNA methylation measurements in b
Externí odkaz:
https://doaj.org/article/d374279e13bb4fddb9705909460fcb20
Autor:
Chathura J. Gunasekara, Harry MacKay, C. Anthony Scott, Shaobo Li, Eleonora Laritsky, Maria S. Baker, Sandra L. Grimm, Goo Jun, Yumei Li, Rui Chen, Joseph L. Wiemels, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first large-scale assessment of mQTL at human genomic regions selected for i
Externí odkaz:
https://doaj.org/article/d2673718183743649c5bae8c0315c583
Autor:
Chathura J. Gunasekara, Eilis Hannon, Harry MacKay, Cristian Coarfa, Andrew McQuillin, David St. Clair, Jonathan Mill, Robert A. Waterland
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Epigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but the cell type-specificity of DNA methylation makes population-based epigenetic studies of SZ challenging. To train an SZ case–control classifier b
Externí odkaz:
https://doaj.org/article/6a95a79bec9a4895ba81aebb8383ea9f
Autor:
C. Anthony Scott, Jack D. Duryea, Harry MacKay, Maria S. Baker, Eleonora Laritsky, Chathura J. Gunasekara, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant differential methylation spanning multiple CpG sites (differentially methylated regions). Variati
Externí odkaz:
https://doaj.org/article/4ae1ac73f7754ba3b8068bc641735177
Autor:
Chathura J. Gunasekara, C. Anthony Scott, Eleonora Laritsky, Maria S. Baker, Harry MacKay, Jack D. Duryea, Noah J. Kessler, Garrett Hellenthal, Alexis C. Wood, Kelly R. Hodges, Manisha Gandhi, Amy B. Hair, Matt J. Silver, Sophie E. Moore, Andrew M. Prentice, Yumei Li, Rui Chen, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this question. At exceptional genomic regions, interindividual variation in DN
Externí odkaz:
https://doaj.org/article/5ad1e273b23e4b7b8400bfdedb7d6255
Autor:
Harry MacKay, Chathura J. Gunasekara, Kit-Yi Yam, Dollada Srisai, Hari Krishna Yalamanchili, Yumei Li, Rui Chen, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Science advances. 8(39)
Recent genome-wide association studies corroborate classical research on developmental programming indicating that obesity is primarily a neurodevelopmental disease strongly influenced by nutrition during critical ontogenic windows. Epigenetic mechan
Autor:
Chathura J Gunasekara, Jack D. Duryea, C. Anthony Scott, Eleonora Laritsky, Robert A. Waterland, Harry MacKay, Maria S. Baker, Cristian Coarfa
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Genome Biology
Genome Biology
Background The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant differential methylation spanning multiple CpG sites (differentially methylated regions). Variation limite
Autor:
Andrew M. Prentice, Robert A. Waterland, Eleonora Laritsky, Noah J. Kessler, David Jeffries, Chathura J Gunasekara, Matt J. Silver, Philip James, Marian Ludgate, Kate A Ward, Sophie E. Moore, Rajavel Elango, Toby Candler, Maria S. Baker, Roger A. Dyer
Publikováno v:
Science Advances
Description
Child PAX8 methylation is associated with thyroid volume and function and influenced by maternal periconceptional nutrition.
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, an
Child PAX8 methylation is associated with thyroid volume and function and influenced by maternal periconceptional nutrition.
PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ad44f0389929233d8693d498ea5e0e
https://www.repository.cam.ac.uk/handle/1810/332188
https://www.repository.cam.ac.uk/handle/1810/332188
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Identification of biological process- and pathway-specific regulators is essential for advancing our understanding of regulation and formation of various phenotypic and complex traits. In this study, we applied two methods, triple-gene mutual interac
Autor:
Andrew McQuillin, Eilis Hannon, Robert A. Waterland, David St Clair, Chathura J Gunasekara, Cristian Coarfa, Harry MacKay, Jonathan Mill
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Epigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but the cell type-specificity of DNA methylation makes population-based epigenetic studies of SZ challenging. To train an SZ case–control classifier based on D