Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

Autor: Li, Wenwei, Chen, Yaozong, Prévost, Jérémie, Ullah, Irfan, Lu, Maolin, Gong, Shang Yu, Tauzin, Alexandra, Gasser, Romain, Vézina, Dani, Anand, Sai Priya, Goyette, Guillaume, Chaterjee, Debashree, Ding, Shilei, Tolbert, William D., Grunst, Michael W., Bo, Yuxia, Zhang, Shijian, Richard, Jonathan, Zhou, Fei, Huang, Rick K., Esser, Lothar, Zeher, Allison, Côté, Marceline, Kumar, Priti, Sodroski, Joseph, Xia, Di, Uchil, Pradeep D., Pazgier, Marzena, Finzi, Andrés, Mothes, Walther

Publikováno v: In Cell Reports 11 January 2022 38(2)

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern.

Autor: Li W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Chen Y; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA., Prévost J; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada., Ullah I; Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520., Lu M; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Gong SY; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada., Tauzin A; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada., Gasser R; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada., Vézina D; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada., Anand SP; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada., Goyette G; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada., Chaterjee D; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada., Ding S; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada., Tolbert WD; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA., Grunst MW; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Bo Y; Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Zhang S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Richard J; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada., Zhou F; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Huang RK; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Esser L; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Zeher A; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Côté M; Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Kumar P; Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520., Sodroski J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Xia D; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Uchil PD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Pazgier M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA., Finzi A; Centre de Recherche du CHUM (CRCHUM), Montreal, QC H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada., Mothes W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Aug 03. Date of Electronic Publication: 2021 Aug 03.