Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance

Autor: Papon, Nicolas, Noël, Thierry, Florent, Martine, Gibot-Leclerc, Stéphanie, Jean, Dorothée, Chastin, Christiane, Villard, Jean, Chapeland-Leclerc, Florence

Publikováno v: Antimicrobial Agents and Chemotherapy, Vol. 51, No 1 (2007) pp. 369-371
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (1), pp.369-71. ⟨10.1128/AAC.00824-06⟩

International audience; Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resi

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Nonsense and Missense Mutations in FCY2and FCY1Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of Candida lusitaniae

Autor: Florent, Martine, Noël, Thierry, Ruprich-Robert, Gwenaël, Da Silva, Bruno, Fitton-Ouhabi, Valérie, Chastin, Christiane, Papon, Nicolas, Chapeland-Leclerc, Florence

Publikováno v: Antimicrobial Agents and Chemotherapy; July 2009, Vol. 53 Issue: 7 p2982-2990, 9p

Inactivation of the FCY2 Gene Encoding Purine-Cytosine Permease Promotes Cross-Resistance to Flucytosine and Fluconazole in Candida lusitaniae

Autor: Chapeland-Leclerc, Florence, Bouchoux, Julien, Goumar, Abdelhak, Chastin, Christiane, Villard, Jean, Noël, Thierry

Publikováno v: Antimicrobial Agents and Chemotherapy; August 2005, Vol. 49 Issue: 8 p3101-3108, 8p

Alternative Identification Test Relying upon Sexual Reproductive Abilities of CandidalusitaniaeStrains Isolated from Hospitalized Patients

Autor: Franc¸ois, Fabienne, Noe¨l, Thierry, Pe´pin, Re´gis, Brulfert, Annie, Chastin, Christiane, Favel, Anne, Villard, Jean

Publikováno v: Journal of Clinical Microbiology; November 2001, Vol. 39 Issue: 11 p3906-3914, 9p