Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Chase M Carver"'
Autor:
Luke E Whitmire, Ling Ling, Vladslav Bugay, Chase M Carver, Santosh Timilsina, Hui-Hsiu Chuang, David B Jaffe, Mark S Shapiro, Jose E Cavazos, Robert Brenner
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188064 (2017)
A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Voltage- and calcium-activated K+ (BK) channels contribute to early spike timing in neurons, and studies indicate that
Externí odkaz:
https://doaj.org/article/d4f281d15dae414db4babdee93ae8b4e
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the pari
Externí odkaz:
https://doaj.org/article/82acaacb1a83472a8e7534a1596ed35b
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Kv7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability. They act as a “brake” against hyperexcitable states in the central and peripheral nervous systems. Pharmacological augmentation of M current has been
Externí odkaz:
https://doaj.org/article/e6cc7fe49bca467da1072daca88a96b2
Autor:
Ashley Y. Gao, Ana M. Diaz Espinosa, Fiorenza Gianì, Tho X. Pham, Chase M. Carver, Aja Aravamudhan, Colleen M. Bartman, Giovanni Ligresti, Nunzia Caporarello, Marissa J. Schafer, Andrew J. Haak
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology.
Cellular senescence is emerging as a driver of idiopathic pulmonary fibrosis (IPF), a progressive and fatal disease with limited effective therapies. The senescence-associated secretory phenotype (SASP), involving the release of inflammatory cytokine
Autor:
Sonia L, Rodriguez, Chase M, Carver, Andrew J, Dosch, Derek M, Huffman, Felicia D, Duke Boynton, Katayoun, Ayasoufi, Marissa J, Schafer
Publikováno v:
Frontiers in Aging. 3
Surgical parabiosis enables sharing of the circulating milieu between two organisms. This powerful model presents diverse complications based on age, strain, sex, and other experimental parameters. Here, we provide an optimized parabiosis protocol fo
Autor:
Han Hao, Ce Liang, Xiaona Du, Nikita Gamper, Dongyang Huang, Frederick Jones, Alexandra S. Hogea, Shihab Shah, Chase M. Carver
Publikováno v:
The Journal of Physiology. 599:2103-2123
Key points Rat somatosensory neurons express a junctional protein, junctophilin-4 (JPH4) JPH4 is necessary for the formation of store operated Ca2+ entry (SOCE) complex at the junctions between plasma membrane and endoplasmic reticulum in these neuro
Publikováno v:
J Biol Chem
The plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates the activity of diverse ion channels to include the epithelial Na(+) channel ENaC. Whether PIP(2) regulation of ENaC is due to a direct phospholipid-protein int
Publikováno v:
Hippocampus
M-type (KCNQ2/3) K(+) channels play dominant roles in regulation of active and passive neuronal discharge properties such as resting membrane potential, spike-frequency adaptation, and hyper-excitatory states. However, plasticity of M-channel express
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience, Vol 15 (2021)
We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the pari
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature communications. 13(1)
Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In the aged brain, senescent cell identities and the mechanisms by which they exert adverse influence are unclear. Here we used high-dimensional molecular profili