Zobrazeno 1 - 10
of 1 409
pro vyhledávání: '"Chase L"'
Autor:
Chunlei Jiao, Natalia L. Peeck, Jiaqi Yu, Mohammad Ghaem Maghami, Sarah Kono, Daphne Collias, Sandra L. Martinez Diaz, Rachael Larose, Chase L. Beisel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Many CRISPR-Cas immune systems generate guide (g)RNAs using trans-activating CRISPR RNAs (tracrRNAs). Recent work revealed that Cas9 tracrRNAs could be reprogrammed to convert any RNA-of-interest into a gRNA, linking the RNA’s presence to
Externí odkaz:
https://doaj.org/article/fae1f70b488348a591a8db8b7fd3dca3
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Alkaline polymer membrane electrochemical energy conversion devices offer the prospect of using non-platinum group catalysts. However, their cationic functionalities are currently not sufficiently stable for vapor-phase applications, such as
Externí odkaz:
https://doaj.org/article/dc6cff6a316341fe8269f33f0698f0df
Autor:
Aranzazu Arias-Rojas, Adini Q Arifah, Georgia Angelidou, Belal Alshaar, Ursula Schombel, Emma Forest, Dagmar Frahm, Volker Brinkmann, Nicole Paczia, Chase L Beisel, Nicolas Gisch, Igor Iatsenko
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012462 (2024)
Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. The role of MprF in commensals remains, however, uncharacterized. To cl
Externí odkaz:
https://doaj.org/article/0c6cb570cd50400c90092644d5058a49
Autor:
Yanying Yu, Sandra Gawlitt, Lisa Barros de Andrade e Sousa, Erinc Merdivan, Marie Piraud, Chase L. Beisel, Lars Barquist
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract CRISPR interference (CRISPRi) is the leading technique to silence gene expression in bacteria; however, design rules remain poorly defined. We develop a best-in-class prediction algorithm for guide silencing efficiency by systematically inve
Externí odkaz:
https://doaj.org/article/b3fe9104d58c45dab45798f7f6947605
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 666-680 (2023)
CRISPR technologies comprising a Cas nuclease and a guide RNA (gRNA) can utilize multiple gRNAs to enact multi-site editing or regulation in the same cell. Nature devised a highly compact means of encoding gRNAs in the form of CRISPR arrays composed
Externí odkaz:
https://doaj.org/article/fde7e1846cdc41ca814ee8c762767e35
Publikováno v:
Ecology and Evolution, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Understanding how tropical forests respond to abiotic environmental changes is critical for preserving biodiversity, mitigating climate change, and maintaining ecosystem services in the coming century. To evaluate the relative roles of the a
Externí odkaz:
https://doaj.org/article/3a82d3dda3a747dcb9593618b5c0eeb3
Autor:
Ronay Cetin, Martin Wegner, Leah Luwisch, Sarada Saud, Tatjana Achmedov, Sebastian Süsser, Antonella Vera-Guapi, Konstantin Müller, Yves Matthess, Eva Quandt, Simone Schaubeck, Chase L. Beisel, Manuel Kaulich
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract CRISPR-based gene perturbation enables unbiased investigations of single and combinatorial genotype-to-phenotype associations. In light of efforts to map combinatorial gene dependencies at scale, choosing an efficient and robust CRISPR-assoc
Externí odkaz:
https://doaj.org/article/0cb5e2ca754b4bf893f7228f118c97be
Autor:
Daphne Collias, Elena Vialetto, Jiaqi Yu, Khoa Co, Éva d. H. Almási, Ann-Sophie Rüttiger, Tatjana Achmedov, Till Strowig, Chase L. Beisel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Genome editing in bacteria normally requires efficient recombination and high transformation efficiencies, which often isn’t. Here the authors report that systematically attenuating DNA targeting activity enables RecA-mediated repair in different b
Externí odkaz:
https://doaj.org/article/6847d05963c14cdda861862000397aca
Publikováno v:
The Astrophysical Journal, Vol 975, Iss 1, p 153 (2024)
The spin–orbit alignment of binary stars traces their formation and accretion history. Previous studies of spin–orbit alignment have been limited to small samples, slowly rotating solar-type stars, and/or wide visual binaries that not surprisingl
Externí odkaz:
https://doaj.org/article/9ae3a32dc79a4d69a8df71a2b2783f26
Autor:
Chandler C. Roe, Olivia Holiday, Kelly Upshaw-Bia, Gaven Benally, Charles H. D. Williamson, Jennifer Urbanz, Guilherme G. Verocai, Chase L. Ridenour, Roxanne Nottingham, Morgan A. Ford, Derek P. Lake, Theodore A. Kennedy, Crystal M. Hepp, Jason W. Sahl
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Onchocerca lupi (Rodonaja, 1967) is an understudied, vector-borne, filarioid nematode that causes ocular onchocercosis in dogs, cats, coyotes, wolves, and is also capable of infecting humans. Onchocercosis in dogs has been reported with increasing in
Externí odkaz:
https://doaj.org/article/4ce853a7732a40798b29cf446071fd96