Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chase Baune"'
Autor:
Bradley R. Groveman, Brent Race, Simote T. Foliaki, Katie Williams, Andrew G. Hughson, Chase Baune, Gianluigi Zanusso, Cathryn L. Haigh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes o
Externí odkaz:
https://doaj.org/article/3c5bd4382a434ac5b0e23d8a75101206
Autor:
Brent Race, Chase Baune, Katie Williams, James F. Striebel, Andrew G. Hughson, Bruce Chesebro
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-9 (2022)
Abstract Chronic wasting disease (CWD) is a prion disease of cervids including deer, elk, reindeer, and moose. Human consumption of cervids is common, therefore assessing the risk potential of CWD transmission to humans is critical. In a previous stu
Externí odkaz:
https://doaj.org/article/b984f435e5da496dbfd4f1678c8d4255
Autor:
Simote T. Foliaki, Aleksandar Wood, Katie Williams, Anna Smith, Ryan O. Walters, Chase Baune, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102733- (2023)
Cellular prion protein (PrPC) protects neurons against oxidative stress damage. This role is lost upon its misfolding into insoluble prions in prion diseases, and correlated with cytoskeletal breakdown and neurophysiological deficits. Here we used mo
Externí odkaz:
https://doaj.org/article/434f51e1d13442429fb7e4e62f8c8170
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/ce719585b7a74ff686d0c8c1896b8de2
Autor:
Chase Baune, Bradley R Groveman, Andrew G Hughson, Tina Thomas, Barry Twardoski, Suzette Priola, Bruce Chesebro, Brent Race
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290325 (2023)
Prion diseases are transmissible, fatal neurologic diseases that include Creutzfeldt-Jakob Disease (CJD) in humans, chronic wasting disease (CWD) in cervids, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep. Prions are extremely
Externí odkaz:
https://doaj.org/article/4beb6980eb9a42c2962ac0f3ac764288
Autor:
Forrest Hoyt, Parvez Alam, Efrosini Artikis, Cindi L Schwartz, Andrew G Hughson, Brent Race, Chase Baune, Gregory J Raymond, Gerald S Baron, Allison Kraus, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010947 (2022)
Prion strains in a given type of mammalian host are distinguished by differences in clinical presentation, neuropathological lesions, survival time, and characteristics of the infecting prion protein (PrP) assemblies. Near-atomic structures of prions
Externí odkaz:
https://doaj.org/article/3ba439d713654222b77cf5fa681300c3
Autor:
Brent Race, Katie Williams, Chase Baune, James F Striebel, Dan Long, Tina Thomas, Lori Lubke, Bruce Chesebro, James A Carroll
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276850 (2022)
Microglia (MG) are critical to host defense during prion infection, but the mechanism(s) of this neuroprotection are poorly understood. To better examine the influence of MG during prion infection, we reduced MG in the brains of C57BL/10 mice using P
Externí odkaz:
https://doaj.org/article/b90142fc5ab64bad844784039a752e26
Autor:
Chase Baune, Lisa L. Wolfe, Kristen C. Schott, Karen A. Griffin, Andrew G. Hughson, Michael W. Miller, Brent Race
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT Chronic wasting disease (CWD) is a transmissible prion disease first observed in the 1960s in North America. This invariably fatal disease affects multiple cervid species in the wild and in captivity. In addition to the several known transmi
Externí odkaz:
https://doaj.org/article/3650344da9d14bf9ad728e648e79feb2
Autor:
Simote T. Foliaki, Brent Race, Katie Williams, Chase Baune, Bradley R. Groveman, Cathryn L. Haigh
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the hallmark spongiform change seen in the brain, these diseases manifest increased oxidative da
Externí odkaz:
https://doaj.org/article/fd6687d15ac742fca4e0aa6fba46e13b
Autor:
Brent Race, Katie Williams, Chase Baune, James F. Striebel, Clayton W. Winkler, James A. Carroll, Sandra E. Encalada, Bruce Chesebro
Publikováno v:
Viruses, Vol 13, Iss 7, p 1391 (2021)
In prion diseases, the spread of infectious prions (PrPSc) is thought to occur within nerves and across synapses of the central nervous system (CNS). However, the mechanisms by which PrPSc moves within axons and across nerve synapses remain undetermi
Externí odkaz:
https://doaj.org/article/ee9947329e504735bca8307e5764e9d5