Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Charulatha Vedhachalam"'
Autor:
Momoe Kono, Toshitaka Tanaka, Masafumi Tanaka, Charulatha Vedhachalam, Palaniappan S. Chetty, David Nguyen, Padmaja Dhanasekaran, Sissel Lund-Katz, Michael C. Phillips, Hiroyuki Saito
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 809-818 (2010)
Apolipoprotein A-I (apoA-I) Nichinan, a naturally occurring variant with ΔE235 in the C terminus, is associated with low plasma HDL levels. Here, we investigated the tertiary structure, lipid-binding properties, and ability to induce cellular choles
Externí odkaz:
https://doaj.org/article/057070bea4224aea956e63f55926f621
Influence of Apolipoprotein A-I Domain Structure on Macrophage Reverse Cholesterol Transport in Mice
Autor:
Michael C. Phillips, Daniel J. Rader, Margarita de la Llera-Moya, Eric T. Alexander, Sandhya Sankaranarayanan, George H. Rothblat, Charulatha Vedhachalam
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:320-327
Objective— The goal of this study was to determine the influence of apolipoprotein A-I (apoA-I) tertiary structure domain properties on the antiatherogenic properties of the protein. Two chimeric hybrids with the N-terminal domains swapped (human-m
Autor:
Michael C. Phillips, Palaniappan Sevugan Chetty, Charulatha Vedhachalam, Sissel Lund-Katz, Padmaja Dhanasekaran, Margaret Nickel, George H. Rothblat
Publikováno v:
Journal of Biological Chemistry. 285:31965-31973
The principal protein of high density lipoprotein (HDL), apolipoprotein (apo) A-I, in the lipid-free state contains two tertiary structure domains comprising an N-terminal helix bundle and a less organized C-terminal domain. It is not known how the p
Autor:
Padmaja Dhanasekaran, Charulatha Vedhachalam, Hiroyuki Saito, Masafumi Tanaka, Sissel Lund-Katz, Momoe Kono, Palaniappan Sevugan Chetty, Michael C. Phillips, David Nguyen, Toshitaka Tanaka
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 809-818 (2010)
Apolipoprotein A-I (apoA-I) Nichinan, a naturally occurring variant with DeltaE235 in the C terminus, is associated with low plasma HDL levels. Here, we investigated the tertiary structure, lipid-binding properties, and ability to induce cellular cho
Autor:
Charulatha Vedhachalam, Trudy M. Forte, Vasanthy Narayanaswami, Nicole Neto, Sissel Lund-Katz, John K. Bielicki, Michael C. Phillips
Publikováno v:
Biochemistry. 46:2583-2593
This study was undertaken to identify the alpha-helical domains of human apoE that mediate cellular cholesterol efflux and HDL assembly via ATP-binding cassette transporter A1 (ABCA1). The C-terminal (CT) domain (residues 222-299) of apoE was found t
Effect of Carboxyl-Terminal Truncation on Structure and Lipid Interaction of Human Apolipoprotein E4
Autor:
Padmaja Dhanasekaran, Michael C. Phillips, Takaaki Sakamoto, Hiroyuki Saito, Charulatha Vedhachalam, Masafumi Tanaka, Sissel Lund-Katz
Publikováno v:
Biochemistry. 45:4240-4247
Apolipoprotein (apo) E4 has been identified as a major risk factor for Alzheimer's disease. Recently, apoE4 was found to undergo proteolytic cleavage in Alzheimer's disease brains, resulting in neurotoxic C-terminal-truncated fragments. In this study
Autor:
Hyun-Duck Nah, Maurizio Pacifici, Ali Fakhry, Imad Salhab, Eiki Koyama, Charulatha Vedhachalam, Phoeby Leboy, Richard E. Kirschner, Chootima Ratisoontorn
Publikováno v:
Bone. 36:254-266
Systemically administered fibroblast growth factors (FGFs) show anabolic effects on bone formation in animals, whereas in vitro cell culture studies have demonstrated that FGFs block mineralized bone nodule formation. These apparently contradictory o
Autor:
Michael C. Phillips, Charulatha Vedhachalam, George H. Rothblat, Daniel J. Rader, Eric T. Alexander, Ginny L. Weibel, Michelle R. Joshi, Margarita de la Llera-Moya
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 29(10)
Objective— To compare the abilities of human wild-type apoA-I (WT apoA-I) and human apoA-I Milano (apoA-I M ) to promote macrophage reverse cholesterol transport (RCT) in apoA-I–null mice infected with adeno-associated virus (AAV) expressing eith
Autor:
Masafumi Tanaka, Hiroyuki Saito, David Nguyen, Sissel Lund-Katz, Padmaja Dhanasekaran, Takaaki Sakamoto, Margaret Nickel, Charulatha Vedhachalam, Michael C. Phillips
To understand the molecular basis for the different self-association and lipoprotein preferences of apolipoprotein (apo) E isoforms, we compared the effects of progressive truncation of the C-terminal domain in human apoE3 and apoE4 on their lipid-fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc627b8fca58d13cda99cfe7352b8b7
https://europepmc.org/articles/PMC2692928/
https://europepmc.org/articles/PMC2692928/
Autor:
Sissel Lund-Katz, Michael C. Phillips, George H. Rothblat, Amy B. Ghering, W. Sean Davidson, Charulatha Vedhachalam
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 27(7)
Objective— The purpose of this study was to understand the interactions of apoA-I with cells expressing ABCA1. Methods and Results— The binding of wild-type (WT) and mutant forms of human apoA-I to mouse J774 macrophages was examined. Analysis of