Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Charmaine Griffiths"'
Autor:
I. Walker, Andrew Goddard, Charmaine Griffiths, Nicholas S Hopkinson, Maggie Rae, Jeanelle de Gruchy, Linda Bauld, Helen J Stokes-Lampard, Sarah Woolnough, Jon Bennett, Jennifer Dixon
Two years ago today the government announced its ambition to make England smoke-free by 2030.12 This includes making smoked tobacco obsolete, with smokers quitting or moving to reduced risk products like e-cigarettes. Despite acknowledging that it wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb033bcc04674620834798b0767440ca
http://hdl.handle.net/10044/1/90561
http://hdl.handle.net/10044/1/90561
Autor:
Anastasia Karchevskaya, Tomas C. Bellamy, A. W. Edith Chan, David L. Selwood, Robert G. Keynes, Dieter Riddall, Charmaine Griffiths, John Garthwaite
Publikováno v:
Chemical Biology & Drug Design. 94:1680-1693
During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14da4a9f25f9fa1942b18564f7d156d
https://doi.org/10.1111/cbdd.13572
https://doi.org/10.1111/cbdd.13572
Publikováno v:
Lancet (London, England). 396(10263)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d00a1ae5777fd3af761ae85c8bd8b
https://pubmed.ncbi.nlm.nih.gov/33189187
https://pubmed.ncbi.nlm.nih.gov/33189187
Autor:
Tian Xiao, Zhao, Michalis, Kostapanos, Charmaine, Griffiths, Emma L, Arbon, Annette, Hubsch, Fotini, Kaloyirou, Joanna, Helmy, Stephen P, Hoole, James H F, Rudd, Graham, Wood, Keith, Burling, Simon, Bond, Joseph, Cheriyan, Ziad, Mallat
Publikováno v:
BMJ open. 8(9)
Inflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes (ACSs). Immune responses are also major determinants of the postischaemic injury in myocardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::135d60ad52116fca93ccc9ac53d9770d
https://pubmed.ncbi.nlm.nih.gov/30224390
https://pubmed.ncbi.nlm.nih.gov/30224390
Publikováno v:
British Journal of Pharmacology. 158:1454-1464
Background and purpose: Nitric oxide (NO) controls numerous physiological processes by activation of its receptor, guanylyl cyclase (sGC), leading to the accumulation of 3′-5′ cyclic guanosine monophosphate (cGMP). Ca2+-calmodulin (CaM) regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713aa9f1b772b5bdbf3d75a8aa82993d
https://doi.org/10.1111/j.1476-5381.2009.00416.x
https://doi.org/10.1111/j.1476-5381.2009.00416.x
Publikováno v:
Biochemical Journal. 387:685-694
Mechanisms which inactivate NO (nitric oxide) are probably important in governing the physiological and pathological effects of this ubiquitous signalling molecule. Cells isolated from the cerebellum, a brain region rich in the NO signalling pathway,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e80b15dc1d490bea64ca842c505244
https://doi.org/10.1042/bj20041431
https://doi.org/10.1042/bj20041431
Publikováno v:
Molecular Pharmacology. 64:1349-1356
The signaling molecule nitric oxide (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has been difficult because it has not been possible to administer NO under the steady-state condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a32b7990151241cf2a7f9768f674531
https://doi.org/10.1124/mol.64.6.1349
https://doi.org/10.1124/mol.64.6.1349
Publikováno v:
The Biochemical journal. 369(Pt 2)
NO functions ubiquitously as a biological messenger but has also been implicated in various pathologies, a role supported by many reports that exogenous or endogenous NO can kill cells in tissue culture. In the course of experiments aimed at examinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515c7eec542f7390966ff4788fc4196d
https://pubmed.ncbi.nlm.nih.gov/12366375
https://pubmed.ncbi.nlm.nih.gov/12366375
Publikováno v:
The Journal of biological chemistry. 277(35)
Nitric oxide (NO) signal transduction may involve at least two targets: the guanylyl cyclase-coupled NO receptor (NO(GC)R), which catalyzes cGMP formation, and cytochrome c oxidase, which is responsible for mitochondrial O(2) consumption and which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab2f72e6f20bf6ad30b9ac96201bbf
https://pubmed.ncbi.nlm.nih.gov/12080082
https://pubmed.ncbi.nlm.nih.gov/12080082
Publikováno v:
The European journal of neuroscience. 15(6)
Nitric oxide (NO) may act as a toxin in several neuropathologies, including the brain damage resulting from cerebral ischaemia. Rat striatal slices were used to determine the mechanism of enhanced NO release following simulated ischaemia and, for est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0044b4d1d22a51aab1d134ef0109076e
https://pubmed.ncbi.nlm.nih.gov/11918655
https://pubmed.ncbi.nlm.nih.gov/11918655