eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

Autor: Pilar Martin-Marcos, Fujun Zhou, Charm Karunasiri, Fan Zhang, Jinsheng Dong, Jagpreet Nanda, Shardul D Kulkarni, Neelam Dabas Sen, Mercedes Tamame, Michael Zeschnigk, Jon R Lorsch, Alan G Hinnebusch

Publikováno v: eLife, Vol 6 (2017)

The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation. The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact

Externí odkaz: https://doaj.org/article/7006477ad03e4f8990e1460bfec1891b

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

Autor: Shardul D. Kulkarni, Charm Karunasiri, Fujun Zhou, Fan Zhang, Mercedes Tamame, Jagpreet S. Nanda, Jinsheng Dong, Alan G. Hinnebusch, Jon R. Lorsch, Michael Zeschnigk, Pilar Martin-Marcos, Neelam Dabas Sen

Publikováno v: GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
Digital.CSIC. Repositorio Institucional del CSIC
eLife, Vol 6 (2017)
eLife

The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon in favorable context, and AUG recognition stabilizes a closed PIC conformation. The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ebdbe43ae886bd40fcfe09e690c8ff
https://www.ncbi.nlm.nih.gov/pubmed/29206102