Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies

Autor: Maëlick Brochut, Tytti Heinonen, Tiia Snäkä, Charly Gilbert, Didier Le Roy, Thierry Roger

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Preclinical mouse models are critical for understanding the pathophysiological response to infections and developing treatment strategies for sepsis. In keeping with ethical values, researchers follow guidelines to minimize the suffering of

Externí odkaz: https://doaj.org/article/29691237f9334e90a6f4d31ecf388e54

Modes of action and diagnostic value of miRNAs in sepsis

Autor: Nikolaos Antonakos, Charly Gilbert, Charlotte Théroude, Irene T. Schrijver, Thierry Roger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by unbal

Externí odkaz: https://doaj.org/article/eef36361e5e1400e9f37899db05cc5db

Age-Related Expression of IFN-lambda1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Autor: Charly Gilbert, Caroline Lefeuvre, Laurence Preisser, Adeline Pivert, Raffaella Soleti, Simon Blanchard, Yves Delneste, Alexandra Ducancelle, Dominique Couez, Pascale Jeannin

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, Online ahead of print. ⟨10.3389/fimmu.2021.750279⟩
Frontiers in Immunology, Frontiers, 2021, 12, Online ahead of print. ⟨10.3389/fimmu.2021.750279⟩
Frontiers in Immunology, Frontiers, 2021, Online ahead of print. ⟨10.3389/fimmu.2021.750279⟩
Frontiers in Immunology, Vol 12 (2021)

SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities. Children generally remain asymptomatic to primary infection,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846379c0e218286854a33f1f9f555215
https://www.hal.inserm.fr/inserm-03424094