Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase.

Autor: Mina JGM; Departments of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom., Charlton RL; Departments of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom.; Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Alpizar-Sosa E; Department of Biosciences, University of Durham, South Road, Durham DH1 3LE, United Kingdom.; Wellcome Centre for Integrative Parasitology and Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Escrivani DO; Departments of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom.; Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Brown C; Departments of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom., Alqaisi A; Department of Biosciences, University of Durham, South Road, Durham DH1 3LE, United Kingdom.; Department of Biology, College of Science, University of Baghdad, Baghdad 10071, Iraq., Borsodi MPG; Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Figueiredo CP; School of Pharmacy, Universidade Federal do Rio de Janeiro, 21944-590 Rio de Janeiro, Rio de Janeiro, Brazil., de Lima EV; School of Pharmacy, Universidade Federal do Rio de Janeiro, 21944-590 Rio de Janeiro, Rio de Janeiro, Brazil., Dickie EA; Wellcome Centre for Integrative Parasitology and Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Wei W; Department of Biosciences, University of Durham, South Road, Durham DH1 3LE, United Kingdom., Coutinho-Silva R; Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Merritt A; LifeArc, Open Innovation Campus, Stevenage SG1 2FX, United Kingdom., Smith TK; BSRC, Schools of Biology and Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom., Barrett MP; Wellcome Centre for Integrative Parasitology and Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Rossi-Bergmann B; Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Denny PW; Department of Biosciences, University of Durham, South Road, Durham DH1 3LE, United Kingdom., Steel PG; Departments of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2021 Jan 08; Vol. 7 (1), pp. 47-63. Date of Electronic Publication: 2020 Dec 08.

Identification of potential inhibitor against Leishmania donovani mitochondrial DNA primase through in-silico and in vitro drug repurposing approaches.

Autor: Nath, Mitul¹ (AUTHOR), Bhowmik, Deep¹ (AUTHOR), Saha, Satabdi¹ (AUTHOR), Nandi, Rajat¹ (AUTHOR), Kumar, Diwakar¹ (AUTHOR) diwakar11@gmail.com

Publikováno v: Scientific Reports. 2/8/2024, Vol. 14 Issue 1, p1-19. 19p.

Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents.

Autor: Setshedi, Koketso J., Beteck, Richard M., Ilbeigi, Kayhan, Mabille, Dorien, Caljon, Guy, Legoabe, Lesetja J.

Publikováno v: Medicinal Chemistry Research; Jun2024, Vol. 33 Issue 6, p977-988, 12p

Applied Machine Learning Toward Drug Discovery Enhancement: Leishmaniases as a Case Study.

Autor: Harigua-Souiai, Emna¹ (AUTHOR) harigua.emna@gmail.com, Oualha, Rafeh¹ (AUTHOR), Souiai, Oussama² (AUTHOR), Abdeljaoued-Tej, Ines^2,3 (AUTHOR), Guizani, Ikram¹ (AUTHOR)

Publikováno v: Bioinformatics & Biology Insights. 4/22/2022, p1-10. 10p.

Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani.

Autor: Hassan, Ahmed H. E.^1,2 (AUTHOR), Phan, Trong-Nhat³ (AUTHOR), Yoon, Seolmin⁴ (AUTHOR), Lee, Cheol Jung⁴ (AUTHOR), Jeon, Hye Rim⁴ (AUTHOR), Kim, Seung-Hwan⁴ (AUTHOR), No, Joo Hwan³ (AUTHOR), Lee, Yong Sup^2,4 (AUTHOR)

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2021, Vol. 36 Issue 1, p1922-1930. 9p.