Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Charlotte X. Dong"'
Autor:
Wilson K. M. Wong, Vinod Thorat, Mugdha V. Joglekar, Charlotte X. Dong, Hugo Lee, Yi Vee Chew, Adwait Bhave, Wayne J. Hawthorne, Feyza Engin, Aniruddha Pant, Louise T. Dalgaard, Sharda Bapat, Anandwardhan A. Hardikar
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Machine learning (ML)-workflows enable unprejudiced/robust evaluation of complex datasets. Here, we analyzed over 490,000,000 data points to compare 10 different ML-workflows in a large (N=11,652) training dataset of human pancreatic single-cell (sc-
Externí odkaz:
https://doaj.org/article/4c6b7c34dcfa4335982bc4796e302990
Autor:
Mugdha V. Joglekar, Subhshri Sahu, Wilson K.M. Wong, Sarang N. Satoor, Charlotte X. Dong, Ryan J. Farr, Michael D. Williams, Prapti Pandya, Gaurang Jhala, Sundy N.Y. Yang, Yi Vee Chew, Nicola Hetherington, Dhan Thiruchevlam, Sasikala Mitnala, Guduru V. Rao, Duvvuru Nageshwar Reddy, Thomas Loudovaris, Wayne J. Hawthorne, Andrew G. Elefanty, Vinay M. Joglekar, Edouard G. Stanley, David Martin, Helen E. Thomas, David Tosh, Louise T. Dalgaard, Anandwardhan A. Hardikar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1530-1553.e4 (2022)
Background & Aims: Pancreatic islet β-cells are factories for insulin production; however, ectopic expression of insulin also is well recognized. The gallbladder is a next-door neighbor to the developing pancreas. Here, we wanted to understand if ga
Externí odkaz:
https://doaj.org/article/3d728a223a8941f1b6deb7467c5a4e8a
Autor:
Wilson K.M. Wong, Mugdha V. Joglekar, Vijit Saini, Guozhi Jiang, Charlotte X. Dong, Alissa Chaitarvornkit, Grzegorz J. Maciag, Dario Gerace, Ryan J. Farr, Sarang N. Satoor, Subhshri Sahu, Tejaswini Sharangdhar, Asma S. Ahmed, Yi Vee Chew, David Liuwantara, Benjamin Heng, Chai K. Lim, Julie Hunter, Andrzej S. Januszewski, Anja E. Sørensen, Ammira S.A. Akil, Jennifer R. Gamble, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Philip J. O'Connell, Gilles J. Guillemin, David Martin, Ann M. Simpson, Wayne J. Hawthorne, Louise T. Dalgaard, Ronald C.W. Ma, Anandwardhan A. Hardikar
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102379- (2021)
Summary: Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic β-cell function. Studies to identify specific microRNA(s) associated with human (pro-)endocrine gene expression are needed. We profiled microRNAs and key pancre
Externí odkaz:
https://doaj.org/article/016725883f2b42db88e23b368f58c758
Autor:
Wilson K. M. Wong, Louise Torp Dalgaard, Charlotte X. Dong, Anandwardhan A. Hardikar, Mugdha V. Joglekar
Publikováno v:
Acta Physiologica. 233
Autor:
Vinod Thorat, Louise Torp Dalgaard, Hugo Lee, Adwait Bhave, Wilson K. M. Wong, Charlotte X. Dong, Mugdha V. Joglekar, Sharda Bapat, Anandwardhan A. Hardikar, Wayne J. Hawthorne, Feyza Engin, Aniruddha Pant, Yi Vee Chew
Machine learning (ML)-workflows enable unprejudiced/robust evaluation of complex datasets. Here, we analyzed over 490,000,000 data points to compare 10 different ML-workflows in a large (N=11,652) training dataset of human pancreatic single-cell (sc-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5159a3723e5749d18b49f845ebd9af0
https://doi.org/10.1101/2021.03.27.437353
https://doi.org/10.1101/2021.03.27.437353
Autor:
Vinay M. Joglekar, Nageshwar Reddy D, Sarang N. Satoor, Hetherington N, Charlotte X. Dong, Shu Yang, Pandya P, Williams, Rao Gv, Edouard G. Stanley, Ryan J. Farr, Thomas Loudovaris, Sasikala Mitnala, Jhala G, David Tosh, David Martín, Subhshri Sahu, Andrew George Elefanty, Helen E. Thomas, Vee Chew Y, Anandwardhan A. Hardikar, Louise Torp Dalgaard, Wayne J. Hawthorne, Wilson W.K. Wong, Mugdha V. Joglekar, Thiruchevlam D
ObjectivePancreatic islet β-cells are factories for insulin production; however ectopic expression of insulin is also well recognized. The gallbladder is a next-door neighbour to the developing pancreas. Here, we wanted to understand if gallbladders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719fe460ba1f795e88902398b32adbac
https://doi.org/10.1101/2021.03.02.433636
https://doi.org/10.1101/2021.03.02.433636
Autor:
Philip J. O'Connell, Thomas Loudovaris, Mugdha V. Joglekar, Anja Elaine Sørensen, Ann M. Simpson, Helen E. Thomas, Louise Torp Dalgaard, Ryan J. Farr, Ronald C.W. Ma, Tejaswini Sharangdhar, Ammira S. Akil, Benjamin Heng, Julie Hunter, David Martín, Yi Vee Chew, Charlotte X. Dong, Sarang N. Satoor, Guozhi Jiang, Alissa Chaitarvornkit, David Liuwantara, Andrzej S. Januszewski, Dario Gerace, Jennifer R. Gamble, Vijit Saini, Anandwardhan A. Hardikar, Wayne J. Hawthorne, Chai K. Lim, Asma S. Ahmed, Subhshri Sahu, Wilson K. M. Wong, Gilles J. Guillemin, Grzegorz J. Maciag, Thomas W.H. Kay
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102379-(2021)
iScience
iScience
Summary Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic β-cell function. Studies to identify specific microRNA(s) associated with human (pro-)endocrine gene expression are needed. We profiled microRNAs and key pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b9bd7d128e0e92eee50f7171fea2a
https://hdl.handle.net/10453/153578
https://hdl.handle.net/10453/153578
Autor:
Jeffrey H. Miner, S. K. Li, Andreas Stahl, Patricia L. Brubaker, Charlotte X. Dong, M. A. Poreba
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E899-E907
The antidiabetic intestinal L cell hormone glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and inhibits gastric emptying. GLP-1 secretion is stimulated by luminal oleic acid (OA), which crosses the cell membrane by an unk
Autor:
Wen Zhao, Charlotte X. Dong, Katherine J. Rowland, Sylvie Robine, Tanja Gonska, Chloe J. Solomon, Patricia L. Brubaker, Martin Holzenberger, Cameron A. Ackerley
Publikováno v:
Endocrinology. 155(2)
Glucagon-like peptide-2 (GLP-2) is an intestinal growth-promoting hormone used to treat short bowel syndrome. GLP-2 promotes intestinal growth through a mechanism that involves both IGF-1 and the intestinal-epithelial IGF-1 receptor (IE-IGF-1R). GLP-
Publikováno v:
Gastroenterology. 148:S-129